Systems Modeling to Quantify Safety Risks in Early Drug Development: Using Bifurcation Analysis and Agent-Based Modeling as Examples

por Pin, Carmen, Collins, Teresa, Gibbs, Megan, Kimko, Holly
Publicado 2021

Synthetic Model Combination: A new machine‐learning method for pharmacometric model ensembling

por Chan, Alexander, Peck, Richard, Gibbs, Megan, van der Schaar, Mihaela
Publicado 2023

The potential and pitfalls of artificial intelligence in clinical pharmacology

por Johnson, Martin, Patel, Mishal, Phipps, Alex, van der Schaar, Mihaela, Boulton, Dave, Gibbs, Megan
Publicado 2023

Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor

por Kasichayanula, Sreeneeranj, Grover, Anita, Emery, Maurice G., Gibbs, Megan A., Somaratne, Ransi, Wasserman, Scott M., Gibbs, John P.
Publicado 2018

Clinical Pharmacology of Elagolix: An Oral Gonadotropin-Releasing Hormone Receptor Antagonist for Endometriosis

por Shebley, Mohamad, Polepally, Akshanth R., Nader, Ahmed, Ng, Juki W., Winzenborg, Insa, Klein, Cheri E., Noertersheuser, Peter, Gibbs, Megan A., Mostafa, Nael M.
Publicado 2019

Impact of Target‐Mediated Elimination on the Dose and Regimen of Evolocumab, a Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

por Gibbs, John P., Doshi, Sameer, Kuchimanchi, Mita, Grover, Anita, Emery, Maurice G., Dodds, Michael G., Gibbs, Megan A., Somaratne, Ransi, Wasserman, Scott M., Blom, Dirk
Publicado 2016

A Consideration of Fixed Dosing Versus Body Size‐Based Dosing Strategies for Chimeric Antigen Receptor T‐Cell Therapies

por He, Jimmy Zhijian, Wang, Hechuan, Lim, KyoungSoo, Ren, Song, Rollins, Fred, Vallaster, Markus, Wong, Ryan, Stebbings, Richard, Standifer, Nathan, Keefe, Robert, Phipps, Alex, Gibbs, Megan
Publicado 2022

Exposure-Response Analyses of Tremelimumab Monotherapy or in Combination with Durvalumab in Patients with Unresectable Hepatocellular Carcinoma

por Song, Xuyang, Kelley, Robin Kate, Khan, Anis A., Standifer, Nathan, Zhou, Diansong, Lim, KyoungSoo, Krishna, Rajesh, Liu, Lu, Wang, Kun, McCoon, Patricia, Negro, Alejandra, He, Philip, Gibbs, Megan, Kurland, John F., Abou-Alfa, Ghassan K.
Publicado 2023