Protein‐Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol

por Hartman, Alwin M., Gierse, Robin M., Hirsch, Anna K. H.
Publicado 2019

Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin

por Jumde, Varsha R., Mondal, Milon, Gierse, Robin M., Unver, M. Yagiz, Magari, Francesca, van Lier, Roos C. W., Heine, Andreas, Klebe, Gerhard, Hirsch, Anna K. H.
Publicado 2018

First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

por Gierse, Robin M., Oerlemans, Rick, Reddem, Eswar R., Gawriljuk, Victor O., Alhayek, Alaa, Baitinger, Dominik, Jakobi, Harald, Laber, Bernd, Lange, Gudrun, Hirsch, Anna K. H., Groves, Matthew R.
Publicado 2022

Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase

por Jumde, Ravindra P., Guardigni, Melissa, Gierse, Robin M., Alhayek, Alaa, Zhu, Di, Hamid, Zhoor, Johannsen, Sandra, Elgaher, Walid A. M., Neusens, Philipp J., Nehls, Christian, Haupenthal, Jörg, Reiling, Norbert, Hirsch, Anna K. H.
Publicado 2021

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

por Zhu, Di, Johannsen, Sandra, Masini, Tiziana, Simonin, Céline, Haupenthal, Jörg, Illarionov, Boris, Andreas, Anastasia, Awale, Mahendra, Gierse, Robin M., van der Laan, Tridia, van der Vlag, Ramon, Nasti, Rita, Poizat, Mael, Buhler, Eric, Reiling, Norbert, Müller, Rolf, Fischer, Markus, Reymond, Jean-Louis, Hirsch, Anna K. H.
Publicado 2022