γ-Secretase Modulators: Can We Combine Potency with Safety?

por Gijsen, Harrie J. M., Mercken, Marc
Publicado 2012

Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogs

por Tesseur, Ina, Lo, Adrian, Roberfroid, Anouk, Dietvorst, Sofie, Van Broeck, Bianca, Borgers, Marianne, Gijsen, Harrie, Moechars, Diederik, Mercken, Marc, Kemp, John, D’Hooge, Rudi, De Strooper, Bart
Publicado 2013

Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice

por Borghgraef, Peter, Menuet, Clément, Theunis, Clara, Louis, Justin V., Devijver, Herman, Maurin, Hervé, Smet-Nocca, Caroline, Lippens, Guy, Hilaire, Gerard, Gijsen, Harrie, Moechars, Dieder, Van Leuven, Fred
Publicado 2013

Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease

por Szaruga, Maria, Veugelen, Sarah, Benurwar, Manasi, Lismont, Sam, Sepulveda-Falla, Diego, Lleo, Alberto, Ryan, Natalie S., Lashley, Tammaryn, Fox, Nick C., Murayama, Shigeo, Gijsen, Harrie, De Strooper, Bart, Chávez-Gutiérrez, Lucía
Publicado 2015

Selective inhibitors of the PSEN1–gamma-secretase complex

por Serneels, Lutgarde, Narlawar, Rajeshwar, Perez-Benito, Laura, Municoy, Marti, Guallar, Victor, T’Syen, Dries, Dewilde, Maarten, Bischoff, François, Fraiponts, Erwin, Tresadern, Gary, Roevens, Peter W.M., Gijsen, Harrie J.M., De Strooper, Bart
Publicado 2023

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

por Chávez-Gutiérrez, Lucía, Bammens, Leen, Benilova, Iryna, Vandersteen, Annelies, Benurwar, Manasi, Borgers, Marianne, Lismont, Sam, Zhou, Lujia, Van Cleynenbreugel, Simon, Esselmann, Hermann, Wiltfang, Jens, Serneels, Lutgarde, Karran, Eric, Gijsen, Harrie, Schymkowitz, Joost, Rousseau, Frederic, Broersen, Kerensa, De Strooper, Bart
Publicado 2012