A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

por Bent, Eric H., Gilbert, Luke A., Hemann, Michael T.
Publicado 2016

Environmental challenge rewires functional connections among human genes

por Herken, Benjamin W., Wong, Garrett T., Norman, Thomas M., Gilbert, Luke A.
Publicado 2023

A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy

por Yogodzinski, Christopher, Arab, Abolfazl, Pritchard, Justin R., Goodarzi, Hani, Gilbert, Luke A.
Publicado 2021

A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments

por Zhao, Boyang, Rao, Yiyun, Leighow, Scott, O’Brien, Edward P., Gilbert, Luke, Pritchard, Justin R.
Publicado 2022

Cellular response to small molecules that selectively stall protein synthesis by the ribosome

por Liaud, Nadège, Horlbeck, Max A., Gilbert, Luke A., Gjoni, Ketrin, Weissman, Jonathan S., Cate, Jamie H. D.
Publicado 2019

Effects of a games-based physical education lesson on cognitive function in adolescents

por Gilbert, Luke M., Dring, Karah J., Williams, Ryan A., Boat, Ruth, Sunderland, Caroline, Morris, John G., Nevill, Mary E., Cooper, Simon B.
Publicado 2023

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity

por Nguyen, Duy P., Miyaoka, Yuichiro, Gilbert, Luke A., Mayerl, Steven J., Lee, Brian H., Weissman, Jonathan S., Conklin, Bruce R., Wells, James A.
Publicado 2016

Nucleosomes impede Cas9 access to DNA in vivo and in vitro

por Horlbeck, Max A, Witkowsky, Lea B, Guglielmi, Benjamin, Replogle, Joseph M, Gilbert, Luke A, Villalta, Jacqueline E, Torigoe, Sharon E, Tjian, Robert, Weissman, Jonathan S
Publicado 2016

Versatile protein tagging in cells with split fluorescent protein

por Kamiyama, Daichi, Sekine, Sayaka, Barsi-Rhyne, Benjamin, Hu, Jeffrey, Chen, Baohui, Gilbert, Luke A., Ishikawa, Hiroaki, Leonetti, Manuel D., Marshall, Wallace F., Weissman, Jonathan S., Huang, Bo
Publicado 2016

Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome

por Kuzuoglu-Ozturk, Duygu, Hu, Zhiqiang, Rama, Martina, Devericks, Emily, Weiss, Jacob, Chiang, Gary G., Worland, Stephen T., Brenner, Steven E., Goodarzi, Hani, Gilbert, Luke A., Ruggero, Davide
Publicado 2021

Highly efficient generation of isogenic pluripotent stem cell models using prime editing

por Li, Hanqin, Busquets, Oriol, Verma, Yogendra, Syed, Khaja Mohieddin, Kutnowski, Nitzan, Pangilinan, Gabriella R, Gilbert, Luke A, Bateup, Helen S, Rio, Donald C, Hockemeyer, Dirk, Soldner, Frank
Publicado 2022

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

por Wang, Songnan, Böhnert, Volker, Joseph, Alby J., Sudaryo, Valentino, Swinderman, Jason, Yu, Feiqiao B., Lyu, Xuchao, Skariah, Gemini, Subramanyam, Vishvak, Gilbert, Luke A., Goodarzi, Hani, Lingyin, Li
Publicado 2023

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

por Horlbeck, Max A, Gilbert, Luke A, Villalta, Jacqueline E, Adamson, Britt, Pak, Ryan A, Chen, Yuwen, Fields, Alexander P, Park, Chong Yon, Corn, Jacob E, Kampmann, Martin, Weissman, Jonathan S
Publicado 2016

Integrative identification of non-coding regulatory regions driving metastatic prostate cancer

por Woo, Brian J, Moussavi-Baygi, Ruhollah, Karner, Heather, Karimzadeh, Mehran, Garcia, Kristle, Joshi, Tanvi, Yin, Keyi, Navickas, Albertas, Gilbert, Luke A., Wang, Bo, Asgharian, Hosseinali, Feng, Felix Y., Goodarzi, Hani
Publicado 2023

A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure

por Mendelsohn, Bryce A., Bennett, Neal K., Darch, Maxwell A., Yu, Katharine, Nguyen, Mai K., Pucciarelli, Daniela, Nelson, Maxine, Horlbeck, Max A., Gilbert, Luke A., Hyun, William, Kampmann, Martin, Nakamura, Jean L., Nakamura, Ken
Publicado 2018

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

por Deans, Richard M., Morgens, David W., Ökesli, Ayşe, Pillay, Sirika, Horlbeck, Max A., Kampmann, Martin, Gilbert, Luke A., Li, Amy, Mateo, Roberto, Smith, Mark, Glenn, Jeffrey S., Carette, Jan E., Khosla, Chaitan, Bassik, Michael C.
Publicado 2016

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

por Jost, Marco, Chen, Yuwen, Gilbert, Luke A., Horlbeck, Max A., Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y., Stern, Jacob J., Prota, Andrea E., Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O., Tanenbaum, Marvin E., Weissman, Jonathan S.
Publicado 2017

Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent

por Jost, Marco, Chen, Yuwen, Gilbert, Luke A., Horlbeck, Max A., Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y., Stern, Jacob J., Prota, Andrea E., Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O., Tanenbaum, Marvin E., Weissman, Jonathan S.
Publicado 2020

IFITM proteins assist cellular uptake of diverse linked chemotypes

por Lou, Kevin, Wassarman, Douglas R., Yang, Tangpo, Paung, YiTing, Zhang, Ziyang, O’Loughlin, Thomas A., Moore, Megan K., Egan, Regina K., Greninger, Patricia, Benes, Cyril H., Seeliger, Markus A., Taunton, Jack, Gilbert, Luke A., Shokat, Kevan M.
Publicado 2022

An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer

por Das, Rajdeep, Sjöström, Martin, Shrestha, Raunak, Yogodzinski, Christopher, Egusa, Emily A., Chesner, Lisa N., Chen, William S., Chou, Jonathan, Dang, Donna K., Swinderman, Jason T., Ge, Alex, Hua, Junjie T., Kabir, Shaheen, Quigley, David A., Small, Eric J., Ashworth, Alan, Feng, Felix Y., Gilbert, Luke A.
Publicado 2021