Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development

por Murin, Charles D., Gilchuk, Pavlo, Crowe, James E., Ward, Andrew B.
Publicado 2022

A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein

por Mousa, Jarrod J., Kose, Nurgun, Matta, Pranathi, Gilchuk, Pavlo, Crowe, James E.
Publicado 2017

Antiviral protection by antibodies targeting the glycan cap of Ebola virus glycoprotein requires activation of the complement system

por Bukreyev, Alexander, Ilinykh, Philipp, Huang, Kai, Gunn, Bronwyn, Kuzmina, Natalia, Gilchuk, Pavlo, Alter, Galit, Crowe, James
Publicado 2023

Real-time cell analysis: A high-throughput approach for testing SARS-CoV-2 antibody neutralization and escape

por Suryadevara, Naveenchandra, Gilchuk, Pavlo, Zost, Seth J., Mittal, Nikhil, Zhao, Li Leyna, Crowe, James E., Carnahan, Robert H.
Publicado 2022

Border Patrol Gone Awry: Lung NKT Cell Activation by Francisella tularensis Exacerbates Tularemia-Like Disease

por Hill, Timothy M., Gilchuk, Pavlo, Cicek, Basak B., Osina, Maria A., Boyd, Kelli L., Durrant, Douglas M., Metzger, Dennis W., Khanna, Kamal M., Joyce, Sebastian
Publicado 2015

Identifying and Tracking Low-Frequency Virus-Specific TCR Clonotypes Using High-Throughput Sequencing

por Wolf, Kyle, Hether, Tyler, Gilchuk, Pavlo, Kumar, Amrendra, Rajeh, Ahmad, Schiebout, Courtney, Maybruck, Julie, Buller, R. Mark, Ahn, Tae-Hyuk, Joyce, Sebastian, DiPaolo, Richard J.
Publicado 2018

Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap

por Ilinykh, Philipp A., Santos, Rodrigo I., Gunn, Bronwyn M., Kuzmina, Natalia A., Shen, Xiaoli, Huang, Kai, Gilchuk, Pavlo, Flyak, Andrew I., Younan, Patrick, Alter, Galit, Crowe, James E., Bukreyev, Alexander
Publicado 2018

Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk

por King, Liam B., West, Brandyn R., Moyer, Crystal L., Gilchuk, Pavlo, Flyak, Andrew, Ilinykh, Philipp A., Bombardi, Robin, Hui, Sean, Huang, Kai, Bukreyev, Alexander, Crowe, James E., Saphire, Erica Ollmann
Publicado 2019

Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies

por Murin, Charles D., Gilchuk, Pavlo, Ilinykh, Philipp A., Huang, Kai, Kuzmina, Natalia, Shen, Xiaoli, Bruhn, Jessica F., Bryan, Aubrey L., Davidson, Edgar, Doranz, Benjamin J., Williamson, Lauren E., Copps, Jeffrey, Alkutkar, Tanwee, Flyak, Andrew I., Bukreyev, Alexander, Crowe, James E., Ward, Andrew B.
Publicado 2021

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

por Bangaru, Sandhya, Zhang, Heng, Gilchuk, Iuliia M., Voss, Thomas G., Irving, Ryan P., Gilchuk, Pavlo, Matta, Pranathi, Zhu, Xueyong, Lang, Shanshan, Nieusma, Travis, Richt, Juergen A., Albrecht, Randy A., Vanderven, Hillary A., Bombardi, Robin, Kent, Stephen J., Ward, Andrew B., Wilson, Ian A., Crowe, James E.
Publicado 2018

Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma

por Gilchuk, Pavlo, Guthals, Adrian, Bonissone, Stefano R., Shaw, Jared B., Ilinykh, Philipp A., Huang, Kai, Bombardi, Robin G., Liang, Jenny, Grinyo, Ariadna, Davidson, Edgar, Chen, Elaine C., Gunn, Bronwyn M., Alter, Galit, Saphire, Erica Ollmann, Doranz, Benjamin J., Bukreyev, Alexander, Zeitlin, Larry, Castellana, Natalie, Crowe, James E.
Publicado 2021

Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region

por Schoeder, Clara T., Gilchuk, Pavlo, Sangha, Amandeep K., Ledwitch, Kaitlyn V., Malherbe, Delphine C., Zhang, Xuan, Binshtein, Elad, Williamson, Lauren E., Martina, Cristina E., Dong, Jinhui, Armstrong, Erica, Sutton, Rachel, Nargi, Rachel, Rodriguez, Jessica, Kuzmina, Natalia, Fiala, Brooke, King, Neil P., Bukreyev, Alexander, Crowe, James E., Meiler, Jens
Publicado 2022

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

por Suryadevara, Naveenchandra, Shrihari, Swathi, Gilchuk, Pavlo, VanBlargan, Laura A., Binshtein, Elad, Zost, Seth J., Nargi, Rachel S., Sutton, Rachel E., Winkler, Emma S., Chen, Elaine C., Fouch, Mallorie E., Davidson, Edgar, Doranz, Benjamin J., Chen, Rita E., Shi, Pei-Yong, Carnahan, Robert H., Thackray, Larissa B., Diamond, Michael S., Crowe, James E.
Publicado 2021

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

por Winkler, Emma S., Gilchuk, Pavlo, Yu, Jinsheng, Bailey, Adam L., Chen, Rita E., Chong, Zhenlu, Zost, Seth J., Jang, Hyesun, Huang, Ying, Allen, James D., Case, James Brett, Sutton, Rachel E., Carnahan, Robert H., Darling, Tamarand L., Boon, Adrianus C.M., Mack, Matthias, Head, Richard D., Ross, Ted M., Crowe, James E., Diamond, Michael S.
Publicado 2021

Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

por Greaney, Allison J., Starr, Tyler N., Gilchuk, Pavlo, Zost, Seth J., Binshtein, Elad, Loes, Andrea N., Hilton, Sarah K., Huddleston, John, Eguia, Rachel, Crawford, Katharine H.D., Dingens, Adam S., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Rothlauf, Paul W., Liu, Zhuoming, Whelan, Sean P.J., Carnahan, Robert H., Crowe, James E., Bloom, Jesse D.
Publicado 2020

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

por Greaney, Allison J., Starr, Tyler N., Gilchuk, Pavlo, Zost, Seth J., Binshtein, Elad, Loes, Andrea N., Hilton, Sarah K., Huddleston, John, Eguia, Rachel, Crawford, Katharine H.D., Dingens, Adam S., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Rothlauf, Paul W., Liu, Zhuoming, Whelan, Sean P.J., Carnahan, Robert H., Crowe, James E., Bloom, Jesse D.
Publicado 2021

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

por Chen, Elaine C., Gilchuk, Pavlo, Zost, Seth J., Suryadevara, Naveenchandra, Winkler, Emma S., Cabel, Carly R., Binshtein, Elad, Chen, Rita E., Sutton, Rachel E., Rodriguez, Jessica, Day, Samuel, Myers, Luke, Trivette, Andrew, Williams, Jazmean K., Davidson, Edgar, Li, Shuaizhi, Doranz, Benjamin J., Campos, Samuel K., Carnahan, Robert H., Thorne, Curtis A., Diamond, Michael S., Crowe, James E.
Publicado 2021

BROADLY NEUTRALIZING ANTIBODIES FROM HUMAN SURVIVORS TARGET A CONSERVED SITE IN THE EBOLA VIRUS GLYCOPROTEIN HR2/MPER REGION

por Flyak, Andrew I., Kuzmina, Natalia, Murin, Charles D., Bryan, Christopher, Davidson, Edgar, Gilchuk, Pavlo, Gulka, Christopher P., Ilinykh, Philipp A., Shen, Xiaoli, Huang, Kai, Ramanathan, Palaniappan, Turner, Hannah, Fusco, Marnie L., Lampley, Rebecca, Kose, Nurgun, King, Hannah, Sapparapu, Gopal, Doranz, Benjamin J., Ksiazek, Thomas G., Wright, David W., Saphire, Erica Ollmann, Ward, Andrew B., Bukreyev, Alexander, Crowe, James E.
Publicado 2018

Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes

por Chen, Elaine C., Gilchuk, Pavlo, Zost, Seth J., Ilinykh, Philipp A., Binshtein, Elad, Huang, Kai, Myers, Luke, Bonissone, Stefano, Day, Samuel, Kona, Chandrahaas R., Trivette, Andrew, Reidy, Joseph X., Sutton, Rachel E., Gainza, Christopher, Diaz, Summer, Williams, Jazmean K., Selverian, Christopher N., Davidson, Edgar, Saphire, Erica Ollmann, Doranz, Benjamin J., Castellana, Natalie, Bukreyev, Alexander, Carnahan, Robert H., Crowe, James E.
Publicado 2023

Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections

por Gilchuk, Iuliia, Gilchuk, Pavlo, Sapparapu, Gopal, Lampley, Rebecca, Singh, Vidisha, Kose, Nurgun, Blum, David L., Hughes, Laura J., Satheshkumar, Panayampalli S., Townsend, Michael B., Kondas, Ashley V., Reed, Zachary, Weiner, Zachary, Olson, Victoria A., Hammarlund, Erika, Raue, Hans-Peter, Slifka, Mark K., Slaughter, James C., Graham, Barney S., Edwards, Kathryn M., Eisenberg, Roselyn J., Cohen, Gary H., Joyce, Sebastian, Crowe, James E.
Publicado 2016