Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development

por Gileadi, Opher
Publicado 2014

RecQ helicases in DNA repair and cancer targets

por Newman, Joseph A., Gileadi, Opher
Publicado 2020

Crystal structures of human soluble guanylate cyclase catalytic domains: promiscuity of the dimer interface and a potential allosteric site

por Gileadi, Opher, Allerston, Charles, von Delft, Frank
Publicado 2013

Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase

por Allerston, Charles K., von Delft, Frank, Gileadi, Opher
Publicado 2013

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition

por Cooper, Christopher D.O., Newman, Joseph A., Gileadi, Opher
Publicado 2014

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5

por Newman, Joseph A., Aitkenhead, Hazel, Savitsky, Pavel, Gileadi, Opher
Publicado 2017

Structural Insights into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2

por Newman, Joseph A, Cooper, Christopher D. O., Aitkenhead, Hazel, Gileadi, Opher
Publicado 2015

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

por Newman, Joseph A., Cooper, Christopher D.O., Aitkenhead, Hazel, Gileadi, Opher
Publicado 2015

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION

por Cooper, Christopher D. O., Newman, Joseph A., Aitkenhead, Hazel, Allerston, Charles K., Gileadi, Opher
Publicado 2015

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease

por Levy, Shiri, Allerston, Charles K., Liveanu, Varda, Habib, Mouna R., Gileadi, Opher, Schuster, Gadi
Publicado 2016

The SNM1A DNA repair nuclease

por Baddock, Hannah T., Yosaatmadja, Yuliana, Newman, Joseph A., Schofield, Christopher J., Gileadi, Opher, McHugh, Peter J.
Publicado 2020

Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment

por Aquino, Bruno, Couñago, Rafael M., Verza, Natalia, Ferreira, Lucas M., Massirer, Katlin B., Gileadi, Opher, Arruda, Paulo
Publicado 2017

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities

por Allerston, Charles K., Lee, Sook Y., Newman, Joseph A., Schofield, Christopher J., McHugh, Peter J., Gileadi, Opher
Publicado 2015

EXD2 promotes homologous recombination by facilitating DNA-end resection

por Broderick, Ronan, Nieminuszczy, Jadwiga, Baddock, Hannah T., Deshpande, Rajashree, Gileadi, Opher, Paull, Tanya T., McHugh, Peter J, Niedzwiedz, Wojciech
Publicado 2016

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family

por Baddock, Hannah T, Newman, Joseph A, Yosaatmadja, Yuliana, Bielinski, Marcin, Schofield, Christopher J, Gileadi, Opher, McHugh, Peter J
Publicado 2021

High-throughput production of human proteins for crystallization: The SGC experience

por Savitsky, Pavel, Bray, James, Cooper, Christopher D.O., Marsden, Brian D., Mahajan, Pravin, Burgess-Brown, Nicola A., Gileadi, Opher
Publicado 2010

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity

por Newman, Joseph A., Aitkenhead, Hazel, Gavard, Angeline E., Rota, Ioanna A., Handel, Adam E., Hollander, Georg A., Gileadi, Opher
Publicado 2020

Structural basis of fumarate hydratase deficiency

por Picaud, Sarah, Kavanagh, Kathryn L., Yue, Wyatt W., Lee, Wen Hwa, Muller-Knapp, Susanne, Gileadi, Opher, Sacchettini, James, Oppermann, Udo
Publicado 2011

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo

por Lee, Sook Y., Brem, Jürgen, Pettinati, Ilaria, Claridge, Timothy D. W., Gileadi, Opher, Schofield, Christopher J., McHugh, Peter J.
Publicado 2016

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin

por Lim, Michael, Newman, Joseph A., Williams, Hannah L., Masino, Laura, Aitkenhead, Hazel, Gravard, Angeline E., Gileadi, Opher, Svejstrup, Jesper Q.
Publicado 2019