The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR(+) CD8(+) effector state, and its deletion improves checkpoint blockade

por McClory, Susan E., Bardhan, Oishi, Rome, Kelly S., Giles, Josephine R., Baxter, Amy E., Xu, Lanwei, Gimotty, Phyllis A., Faryabi, Robert B., John Wherry, E., Pear, Warren S., Jordan, Martha S.
Publicado 2023

The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR(+) CD8(+) effector state and its deletion improves checkpoint blockade

por McClory, Susan E., Bardhan, Oishi, Rome, Kelly S., Giles, Josephine R., Baxter, Amy E., Xu, Lanwei, Gimotty, Phyllis A., Faryabi, Robert B., Wherry, E. John, Pear, Warren S., Jordan, Martha S.
Publicado 2023

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

por Abdel-Hakeem, Mohamed S., Manne, Sasikanth, Beltra, Jean-Christophe, Stelekati, Erietta, Chen, Zeyu, Nzingha, Kito, Ali, Mohammed-Alkhatim, Johnson, John L., Giles, Josephine R., Mathew, Divij, Greenplate, Allison R., Vahedi, Golnaz, Wherry, E. John
Publicado 2021

In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40

por Wu, Jennifer E., Manne, Sasikanth, Ngiow, Shin Foong, Baxter, Amy E., Huang, Hua, Freilich, Elizabeth, Clark, Megan L., Lee, Joanna H., Chen, Zeyu, Khan, Omar, Staupe, Ryan P., Huang, Yinghui J., Shi, Junwei, Giles, Josephine R., Wherry, E. John
Publicado 2023

Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction

por Diorio, Caroline, Shraim, Rawan, Vella, Laura A., Giles, Josephine R., Baxter, Amy E., Oldridge, Derek A., Canna, Scott W., Henrickson, Sarah E., McNerney, Kevin O., Balamuth, Frances, Burudpakdee, Chakkapong, Lee, Jessica, Leng, Tomas, Farrel, Alvin, Lambert, Michele P., Sullivan, Kathleen E., Wherry, E. John, Teachey, David T., Bassiri, Hamid, Behrens, Edward M.
Publicado 2021

Signatures of COVID-19 severity and immune response in the respiratory tract microbiome

por Merenstein, Carter, Liang, Guanxiang, Whiteside, Samantha A., Cobián-Güemes, Ana G., Merlino, Madeline S., Taylor, Louis J., Glascock, Abigail, Bittinger, Kyle, Tanes, Ceylan, Graham-Wooten, Jevon, Khatib, Layla A., Fitzgerald, Ayannah S., Reddy, Shantan, Baxter, Amy E., Giles, Josephine R., Oldridge, Derek A., Meyer, Nuala J., Wherry, E. John, McGinniss, John E., Bushman, Frederic D., Collman, Ronald G.
Publicado 2021

Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome

por Merenstein, Carter, Liang, Guanxiang, Whiteside, Samantha A., Cobián-Güemes, Ana G., Merlino, Madeline S., Taylor, Louis J., Glascock, Abigail, Bittinger, Kyle, Tanes, Ceylan, Graham-Wooten, Jevon, Khatib, Layla A., Fitzgerald, Ayannah S., Reddy, Shantan, Baxter, Amy E., Giles, Josephine R., Oldridge, Derek A., Meyer, Nuala J., Wherry, E. John, McGinniss, John E., Bushman, Frederic D., Collman, Ronald G.
Publicado 2021

Correction for Merenstein et al., “Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome”

por Merenstein, Carter, Liang, Guanxiang, Whiteside, Samantha A., Cobián-Güemes, Ana G., Merlino, Madeline S., Taylor, Louis J., Glascock, Abigail, Bittinger, Kyle, Tanes, Ceylan, Graham-Wooten, Jevon, Khatib, Layla A., Fitzgerald, Ayannah S., Reddy, Shantan, Baxter, Amy E., Giles, Josephine R., Oldridge, Derek A., Meyer, Nuala J., Wherry, E. John, McGinniss, John E., Bushman, Frederic D., Collman, Ronald G.
Publicado 2022

TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion

por Khan, Omar, Giles, Josephine R., McDonald, Sierra, Manne, Sasikanth, Ngiow, Shin Foong, Patel, Kunal P., Werner, Michael T., Huang, Alexander C., Alexander, Katherine A., Wu, Jennifer E., Attanasio, John, Yan, Patrick, George, Sangeeth M., Bengsch, Bertram, Staupe, Ryan P., Donahue, Greg, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Kaye, Jonathan, Berger, Shelley L., Wherry, E. John
Publicado 2019

Longitudinal Analysis Reveals Distinct Antibody and Memory B Cell Responses in SARS-CoV2 Naïve and Recovered Individuals Following mRNA Vaccination

por Goel, Rishi R., Apostolidis, Sokratis A., Painter, Mark M., Mathew, Divij, Pattekar, Ajinkya, Kuthuru, Oliva, Gouma, Sigrid, Kuri-Cervantes, Leticia, Meng, Wenzhao, Adamski, Sharon, Baxter, Amy E., Giles, Josephine R., Weirick, Madison E., McAllister, Christopher M., Hicks, Amanda, Korte, Scott, Dougherty, Jeanette, Long, Sherea, D’Andrea, Kurt, Hamilton, Jacob T., Prak, Eline T Luning, Betts, Michael R., Bates, Paul, Hensley, Scott E., Greenplate, Allison R., Wherry, E. John
Publicado 2021

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination

por Goel, Rishi R., Apostolidis, Sokratis A., Painter, Mark M., Mathew, Divij, Pattekar, Ajinkya, Kuthuru, Oliva, Gouma, Sigrid, Hicks, Philip, Meng, Wenzhao, Rosenfeld, Aaron M., Dysinger, Sarah, Lundgreen, Kendall A., Kuri-Cervantes, Leticia, Adamski, Sharon, Hicks, Amanda, Korte, Scott, Oldridge, Derek A., Baxter, Amy E., Giles, Josephine R., Weirick, Madison E., McAllister, Christopher M., Dougherty, Jeanette, Long, Sherea, D’Andrea, Kurt, Hamilton, Jacob T., Betts, Michael R., Luning Prak, Eline T., Bates, Paul, Hensley, Scott E., Greenplate, Allison R., Wherry, E. John
Publicado 2021

Rapid induction of antigen-specific CD4(+) T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

por Painter, Mark M., Mathew, Divij, Goel, Rishi R., Apostolidis, Sokratis A., Pattekar, Ajinkya, Kuthuru, Oliva, Baxter, Amy E., Herati, Ramin S., Oldridge, Derek A., Gouma, Sigrid, Hicks, Philip, Dysinger, Sarah, Lundgreen, Kendall A., Kuri-Cervantes, Leticia, Adamski, Sharon, Hicks, Amanda, Korte, Scott, Giles, Josephine R., Weirick, Madison E., McAllister, Christopher M., Dougherty, Jeanette, Long, Sherea, D’Andrea, Kurt, Hamilton, Jacob T., Betts, Michael R., Bates, Paul, Hensley, Scott E., Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Greenplate, Allison R., Wherry, E. John
Publicado 2021

Trimodal single-cell profiling reveals a novel pediatric CD8αα(+) T cell subset and broad age-related molecular reprogramming across the T cell compartment

por Thomson, Zachary, He, Ziyuan, Swanson, Elliott, Henderson, Katherine, Phalen, Cole, Zaim, Samir Rachid, Pebworth, Mark-Phillip, Okada, Lauren Y., Heubeck, Alexander T., Roll, Charles R., Hernandez, Veronica, Weiss, Morgan, Genge, Palak C., Reading, Julian, Giles, Josephine R., Manne, Sasikanth, Dougherty, Jeanette, Jasen, C. J., Greenplate, Allison R., Becker, Lynne A., Graybuck, Lucas T., Vasaikar, Suhas V., Szeto, Gregory L., Savage, Adam K., Speake, Cate, Buckner, Jane H., Li, Xiao-jun, Bumol, Thomas F., Wherry, E.John, Torgerson, Troy R., Vella, Laura A., Henrickson, Sarah E., Skene, Peter J., Gustafson, Claire E.
Publicado 2023

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

por Apostolidis, Sokratis A., Sarkar, Amrita, Giannini, Heather M., Goel, Rishi R., Mathew, Divij, Suzuki, Aae, Baxter, Amy E., Greenplate, Allison R., Alanio, Cécile, Abdel-Hakeem, Mohamed, Oldridge, Derek A., Giles, Josephine, Wu, Jennifer E., Chen, Zeyu, Huang, Yinghui Jane, Pattekar, Ajinkya, Manne, Sasikanth, Kuthuru, Oliva, Dougherty, Jeanette, Weiderhold, Brittany, Weisman, Ariel R., Ittner, Caroline A. G., Gouma, Sigrid, Dunbar, Debora, Frank, Ian, Huang, Alexander C., Vella, Laura A., Reilly, John P., Hensley, Scott E., Rauova, Lubica, Zhao, Liang, Meyer, Nuala J., Poncz, Mortimer, Abrams, Charles S., Wherry, E. John
Publicado 2021

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

por Goel, Rishi R., Painter, Mark M., Lundgreen, Kendall A., Apostolidis, Sokratis A., Baxter, Amy E., Giles, Josephine R., Mathew, Divij, Pattekar, Ajinkya, Reynaldi, Arnold, Khoury, David S., Gouma, Sigrid, Hicks, Philip, Dysinger, Sarah, Hicks, Amanda, Sharma, Harsh, Herring, Sarah, Korte, Scott, KC, Wumesh, Oldridge, Derek A., Erickson, Rachel I., Weirick, Madison E., McAllister, Christopher M., Awofolaju, Moses, Tanenbaum, Nicole, Dougherty, Jeanette, Long, Sherea, D’Andrea, Kurt, Hamilton, Jacob T., McLaughlin, Maura, Williams, Justine C., Adamski, Sharon, Kuthuru, Oliva, Drapeau, Elizabeth M., Davenport, Miles P., Hensley, Scott E., Bates, Paul, Greenplate, Allison R., Wherry, E. John
Publicado 2022

Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19

por Apostolidis, Sokratis A., Sarkar, Amrita, Giannini, Heather M., Goel, Rishi R., Mathew, Divij, Suzuki, Aae, Baxter, Amy E., Greenplate, Allison R., Alanio, Cécile, Abdel-Hakeem, Mohamed, Oldridge, Derek A., Giles, Josephine R., Wu, Jennifer E., Chen, Zeyu, Huang, Yinghui Jane, Belman, Jonathan, Pattekar, Ajinkya, Manne, Sasikanth, Kuthuru, Oliva, Dougherty, Jeanette, Weiderhold, Brittany, Weisman, Ariel R., Ittner, Caroline A. G., Gouma, Sigrid, Dunbar, Debora, Frank, Ian, Huang, Alexander C., Vella, Laura A., Reilly, John P., Hensley, Scott E., Rauova, Lubica, Zhao, Liang, Meyer, Nuala J., Poncz, Mortimer, Abrams, Charles S., Wherry, E. John
Publicado 2022

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

por Goel, Rishi R., Painter, Mark M., Lundgreen, Kendall A., Apostolidis, Sokratis A., Baxter, Amy E., Giles, Josephine R., Mathew, Divij, Pattekar, Ajinkya, Reynaldi, Arnold, Khoury, David S., Gouma, Sigrid, Hicks, Philip, Dysinger, Sarah, Hicks, Amanda, Sharma, Harsh, Herring, Sarah, Korte, Scott, KC, Wumesh, Oldridge, Derek A., Erickson, Rachel I., Weirick, Madison E., McAllister, Christopher M., Awofolaju, Moses, Tanenbaum, Nicole, Dougherty, Jeanette, Long, Sherea, D’Andrea, Kurt, Hamilton, Jacob T., McLaughlin, Maura, Williams, Justine C., Adamski, Sharon, Kuthuru, Oliva, Drapeau, Elizabeth M., Davenport, Miles P., Hensley, Scott E., Bates, Paul, Greenplate, Allison R., Wherry, E. John
Publicado 2022

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodie...

por Painter, Mark M., Johnston, Timothy S., Lundgreen, Kendall A., Santos, Jefferson J.S., Qin, Juliana S., Goel, Rishi R., Apostolidis, Sokratis A., Mathew, Divij, Fulmer, Bria, Williams, Justine C., McKeague, Michelle L., Pattekar, Ajinkya, Goode, Ahmad, Nasta, Sean, Baxter, Amy E., Giles, Josephine R., Skelly, Ashwin N., Felley, Laura E., McLaughlin, Maura, Weaver, Joellen, Kuthuru, Oliva, Dougherty, Jeanette, Adamski, Sharon, Long, Sherea, Kee, Macy, Clendenin, Cynthia, da Silva Antunes, Ricardo, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Huang, Alexander C., Rader, Daniel J., Hensley, Scott E., Bates, Paul, Greenplate, Allison R., Wherry, E. John
Publicado 2023

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

por Mathew, Divij, Giles, Josephine R., Baxter, Amy E., Greenplate, Allison R., Wu, Jennifer E., Alanio, Cécile, Oldridge, Derek A., Kuri-Cervantes, Leticia, Pampena, M. Betina, D’Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P., Weisman, Ariel R, Ittner, Caroline A.G., Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C., Anderson, Elizabeth M., Weirick, Madison E., Gouma, Sigrid, Arevalo, Claudia P., Bolton, Marcus J., Chen, Fang, Lacey, Simon F., Hensley, Scott E., Apostolidis, Sokratis, Huang, Alexander C., Vella, Laura A., Betts, Michael R., Meyer, Nuala J., Wherry, E. John
Publicado 2020

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

por Mathew, Divij, Giles, Josephine R., Baxter, Amy E., Oldridge, Derek A., Greenplate, Allison R., Wu, Jennifer E., Alanio, Cécile, Kuri-Cervantes, Leticia, Pampena, M. Betina, D’Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P., Weisman, Ariel R., Ittner, Caroline A. G., Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C., Anderson, Elizabeth M., Weirick, Madison E., Gouma, Sigrid, Arevalo, Claudia P., Bolton, Marcus J., Chen, Fang, Lacey, Simon F., Ramage, Holly, Cherry, Sara, Hensley, Scott E., Apostolidis, Sokratis A., Huang, Alexander C., Vella, Laura A., Betts, Michael R., Meyer, Nuala J., Wherry, E. John
Publicado 2020