Pharmacokinetics, Pharmacodynamics, and Tolerability of Concomitant Administration of Verinurad and Febuxostat in Healthy Male Volunteers

por Hall, Jesse, Gillen, Michael, Yang, Xiaojuan, Shen, Zancong
Publicado 2018

In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters

por Shen, Zancong, Yeh, Li-Tain, Wallach, Kathleen, Zhu, Nanqun, Kerr, Brad, Gillen, Michael
Publicado 2016

Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers

por Gillen, Michael, Valdez, Shakti, Zhou, Dongmei, Kerr, Bradley, Lee, Caroline A, Shen, Zancong
Publicado 2016

Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy adult male subjects

por Shen, Zancong, Gillen, Michael, Miner, Jeffrey N, Bucci, Gail, Wilson, David M, Hall, Jesse W
Publicado 2017

Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy Japanese and non-Asian male subjects

por Hall, Jesse, Gillen, Michael, Liu, Sha, Miner, Jeffrey N, Valdez, Shakti, Shen, Zancong, Lee, Caroline
Publicado 2018

Verinurad combined with febuxostat in Japanese adults with gout or asymptomatic hyperuricaemia: a phase 2a, open-label study

por Shiramoto, Masanari, Liu, Sha, Shen, Zancong, Yan, Xiaohong, Yamamoto, Amy, Gillen, Michael, Ito, Yasushi, Hall, Jesse
Publicado 2018

Dose-Ranging and Cumulative Dose Studies of Albuterol Sulfate MDI in Co-Suspension Delivery™ Technology (AS MDI; PT007) in Patients with Asthma: the ASPEN and ANTORA Trials

por Cappelletti, Christy, Maes, Andrea, Rossman, Kimberly, Gillen, Michael, LaForce, Craig, Kerwin, Edward M., Reisner, Colin
Publicado 2021

Pharmacokinetics, pharmacodynamics, and safety of verinurad with and without allopurinol in healthy Asian, Chinese, and non‐Asian participants

por Johansson, Susanne, Han, David, Hunt, Thomas, Björck, Karin, Florica, Delia, Gillen, Michael, Hall, Jesse, Erlandsson, Fredrik
Publicado 2022

Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study

por Shen, Zancong, Gillen, Michael, Tieu, Kathy, Nguyen, Mai, Harmon, Erin, Wilson, David M, Kerr, Bradley, Lee, Caroline A
Publicado 2016

Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clini...

por Martin, Paul, Gillen, Michael, Millson, David, Oliver, Stuart, Brealey, Clive, Grossbard, Elliott B., Baluom, Muhammad, Lau, David, Sweeny, David, Mant, Tim, Craven, Kelli
Publicado 2016

Pharmacodynamic and pharmacokinetic effects and safety of verinurad in combination with allopurinol in adults with gout: a phase IIa, open-label study

por Fleischmann, Roy, Winkle, Peter, Miner, Jeffrey N, Yan, Xiaohong, Hicks, Liz, Valdez, Shakti, Hall, Jesse, Liu, Sha, Shen, Zancong, Gillen, Michael, Hernandez-Illas, Martha
Publicado 2018

Pharmacodynamic and pharmacokinetic effects and safety of verinurad in combination with febuxostat in adults with gout: a phase IIa, open-label study

por Fleischmann, Roy, Winkle, Peter, Hall, Jesse, Valdez, Shakti, Liu, Sha, Yan, Xiaohong, Hicks, Liz, Lee, Caroline, Miner, Jeffrey N, Gillen, Michael, Hernandez-Illas, Martha
Publicado 2018

An Evaluation of the Pharmacokinetics, Safety, and Tolerability of Aclidinium/Formoterol Fixed-Dose Combination Administered in Chinese Patients with Moderate-to-Severe Chronic Obs...

por Zhang, Hong, Daoud, Sami Z., Gillen, Michael S., Calderon, Natalia, Heijer, Maria, Molins, Eduard, Garcia-Gil, Esther, Chen, Hong, Li, Qianqian, Liu, Chengjiao, Ding, Yanhua
Publicado 2022

Pharmacokinetics, Pharmacodynamics, and Tolerability of Concomitant Multiple Dose Administration of Verinurad (RDEA3170) and Allopurinol in Adult Male Subjects With Gout

por Kankam, Martin, Hall, Jesse, Gillen, Michael, Yang, Xiaojuan, Shen, Zancong, Lee, Caroline, Liu, Sha, Miner, Jeffrey N., Walker, Susan, Clauson, Vicki, Wilson, David, Nguyen, Mai
Publicado 2018

Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Verinurad, a Selective Uric Acid Reabsorption Inhibitor

por Smith, William B., Hall, Jesse, Berg, Jolene K., Kazimir, Michal, Yamamoto, Amy, Walker, Susan, Lee, Caroline A., Shen, Zancong, Wilson, David M., Zhou, Dongmei, Gillen, Michael, Marbury, Thomas C.
Publicado 2018