Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

por Gilley, Jonathan, Coleman, Michael P.
Publicado 2010

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

por Gilley, Jonathan, Coffer, Paul J., Ham, Jonathan
Publicado 2003

Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2

por Milde, Stefan, Gilley, Jonathan, Coleman, Michael P.
Publicado 2013

Axonal trafficking of NMNAT2 and its roles in axon growth and survival in vivo

por Milde, Stefan, Gilley, Jonathan, Coleman, Michael P
Publicado 2013

The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons

por Hughes, Rosie, Gilley, Jonathan, Kristiansen, Mark, Ham, Jonathan
Publicado 2011

Sarm1 Deletion, but Not Wld(S), Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

por Gilley, Jonathan, Ribchester, Richard R., Coleman, Michael P.
Publicado 2017

Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival

por Ademi, Mirlinda, Yang, Xiuna, Coleman, Michael P., Gilley, Jonathan
Publicado 2022

MEK Inhibitor U0126 Reverses Protection of Axons from Wallerian Degeneration Independently of MEK–ERK Signaling

por Evans, Catherine, Cook, Simon J., Coleman, Michael P., Gilley, Jonathan
Publicado 2013

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

por Gilley, Jonathan, Orsomando, Giuseppe, Nascimento-Ferreira, Isabel, Coleman, Michael P.
Publicado 2015

The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons

por Towers, Emily, Gilley, Jonathan, Randall, Rebecca, Hughes, Rosie, Kristiansen, Mark, Ham, Jonathan
Publicado 2009

Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration

por Gould, Stacey Anne, Gilley, Jonathan, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank, Coleman, Michael
Publicado 2021

SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites

por Angeletti, Carlo, Amici, Adolfo, Gilley, Jonathan, Loreto, Andrea, Trapanotto, Antonio G., Antoniou, Christina, Merlini, Elisa, Coleman, Michael P., Orsomando, Giuseppe
Publicado 2022

Nicotinamide Mononucleotide Adenylyltransferase 2 (Nmnat2) Regulates Axon Integrity in the Mouse Embryo

por Hicks, Amy N., Lorenzetti, Diego, Gilley, Jonathan, Lu, Baisong, Andersson, Karl-Erik, Miligan, Carol, Overbeek, Paul A., Oppenheim, Ronald, Bishop, Colin E.
Publicado 2012

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

por Rodríguez-Martín, Teresa, Pooler, Amy M., Lau, Dawn H.W., Mórotz, Gábor M., De Vos, Kurt J., Gilley, Jonathan, Coleman, Michael P., Hanger, Diane P.
Publicado 2016

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

por Loreto, Andrea, Hill, Ciaran S., Hewitt, Victoria L., Orsomando, Giuseppe, Angeletti, Carlo, Gilley, Jonathan, Lucci, Cristiano, Sanchez-Martinez, Alvaro, Whitworth, Alexander J., Conforti, Laura, Dajas-Bailador, Federico, Colemana, Michael P.
Publicado 2020

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport

por Yang, Sen, Niou, Zhen-Xian, Enriquez, Andrea, LaMar, Jacob, Huang, Jui-Yen, Ling, Karen, Jafar-Nejad, Paymaan, Gilley, Jonathan, Coleman, Michael P., Tennessen, Jason M., Rangaraju, Vidhya, Lu, Hui-Chen
Publicado 2023

The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila

por Llobet Rosell, Arnau, Paglione, Maria, Gilley, Jonathan, Kocia, Magdalena, Perillo, Giulia, Gasparrini, Massimiliano, Cialabrini, Lucia, Raffaelli, Nadia, Angeletti, Carlo, Orsomando, Giuseppe, Wu, Pei-Hsuan, Coleman, Michael P, Loreto, Andrea, Neukomm, Lukas Jakob
Publicado 2022

Wld(S) protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice

por Conforti, Laura, Wilbrey, Anna, Morreale, Giacomo, Janeckova, Lucie, Beirowski, Bogdan, Adalbert, Robert, Mazzola, Francesca, Di Stefano, Michele, Hartley, Robert, Babetto, Elisabetta, Smith, Trevor, Gilley, Jonathan, Billington, Richard A., Genazzani, Armando A., Ribchester, Richard R., Magni, Giulio, Coleman, Michael
Publicado 2009

Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

por Loreto, Andrea, Angeletti, Carlo, Gu, Weixi, Osborne, Andrew, Nieuwenhuis, Bart, Gilley, Jonathan, Merlini, Elisa, Arthur-Farraj, Peter, Amici, Adolfo, Luo, Zhenyao, Hartley-Tassell, Lauren, Ve, Thomas, Desrochers, Laura M, Wang, Qi, Kobe, Bostjan, Orsomando, Giuseppe, Coleman, Michael P
Publicado 2021

Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders

por Gilley, Jonathan, Jackson, Oscar, Pipis, Menelaos, Estiar, Mehrdad A, Al-Chalabi, Ammar, Danzi, Matt C, van Eijk, Kristel R, Goutman, Stephen A, Harms, Matthew B, Houlden, Henry, Iacoangeli, Alfredo, Kaye, Julia, Lima, Leandro, Ravits, John, Rouleau, Guy A, Schüle, Rebecca, Xu, Jishu, Züchner, Stephan, Cooper-Knock, Johnathan, Gan-Or, Ziv, Reilly, Mary M, Coleman, Michael P
Publicado 2021