Structural basis of the junctional anchorage of the cerebral cavernous malformations complex

por Gingras, Alexandre R., Liu, Jian J., Ginsberg, Mark H.
Publicado 2012

Optogenetics-based localization of talin to the plasma membrane promotes activation of β3 integrins

por Liao, Zhongji, Gingras, Alexandre R., Lagarrigue, Frederic, Ginsberg, Mark H., Shattil, Sanford J.
Publicado 2021

Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development

por Sun, Hao, Lagarrigue, Frederic, Gingras, Alexandre R., Fan, Zhichao, Ley, Klaus, Ginsberg, Mark H.
Publicado 2018

The domain structure of talin: Residues 1815–1973 form a five-helix bundle containing a cryptic vinculin-binding site

por Goult, Benjamin T., Gingras, Alexandre R., Bate, Neil, Barsukov, Igor L., Critchley, David R., Roberts, Gordon C.K.
Publicado 2010

Talin Contains A C-Terminal Calpain2 Cleavage Site Important In Focal Adhesion Dynamics

por Bate, Neil, Gingras, Alexandre R., Bachir, Alexia, Horwitz, Rick, Ye, Feng, Patel, Bipin, Goult, Benjamin T., Critchley, David R.
Publicado 2012

Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity

por de Kreuk, Bart-Jan, Gingras, Alexandre R, Knight, James DR, Liu, Jian J, Gingras, Anne-Claude, Ginsberg, Mark H
Publicado 2016

A mechanism of Rap1-induced stabilization of endothelial cell–cell junctions

por Liu, Jian J., Stockton, Rebecca A., Gingras, Alexandre R., Ablooglu, Ararat J., Han, Jaewon, Bobkov, Andrey A., Ginsberg, Mark H.
Publicado 2011

Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs

por Lee, Ho-Sup, Sun, Hao, Lagarrigue, Frédéric, Kim, Sarah Hyun Ji, Fox, Jay W., Sherman, Nicholas E., Gingras, Alexandre R., Ginsberg, Mark H.
Publicado 2022

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

por Gingras, Alexandre R., Bate, Neil, Goult, Benjamin T., Patel, Bipin, Kopp, Petra M., Emsley, Jonas, Barsukov, Igor L., Roberts, Gordon C. K., Critchley, David R.
Publicado 2010

The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex

por Marshall, Jamie E., Faraj, Bayan H. A., Gingras, Alexandre R., Lonnen, Rana, Sheikh, Md. Arif, El-Mezgueldi, Mohammed, Moody, Peter C. E., Andrew, Peter W., Wallis, Russell
Publicado 2015

The Structure of an Interdomain Complex That Regulates Talin Activity

por Goult, Benjamin T., Bate, Neil, Anthis, Nicholas J., Wegener, Kate L., Gingras, Alexandre R., Patel, Bipin, Barsukov, Igor L., Campbell, Iain D., Roberts, Gordon C. K., Critchley, David R.
Publicado 2009

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

por Goult, Benjamin T., Zacharchenko, Thomas, Bate, Neil, Tsang, Ricky, Hey, Fiona, Gingras, Alexandre R., Elliott, Paul R., Roberts, Gordon C. K., Ballestrem, Christoph, Critchley, David R., Barsukov, Igor L.
Publicado 2013

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

por Goult, Benjamin T, Bouaouina, Mohamed, Elliott, Paul R, Bate, Neil, Patel, Bipin, Gingras, Alexandre R, Grossmann, J Günter, Roberts, Gordon C K, Calderwood, David A, Critchley, David R, Barsukov, Igor L
Publicado 2010

Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem

por Gingras, Alexandre R., Lagarrigue, Frederic, Cuevas, Monica N., Valadez, Andrew J., Zorovich, Marcus, McLaughlin, Wilma, Lopez-Ramirez, Miguel Alejandro, Seban, Nicolas, Ley, Klaus, Kiosses, William B., Ginsberg, Mark H.
Publicado 2019

The structure of the C-terminal actin-binding domain of talin

por Gingras, Alexandre R, Bate, Neil, Goult, Benjamin T, Hazelwood, Larnele, Canestrelli, Ilona, Grossmann, J Günter, Liu, HongJun, Putz, Nicholas S M, Roberts, Gordon C K, Volkmann, Niels, Hanein, Dorit, Barsukov, Igor L, Critchley, David R
Publicado 2008

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1

por Kopp, Petra M., Bate, Neil, Hansen, Tania M., Brindle, Nicholas P.J., Praekelt, Uta, Debrand, Emmanuel, Coleman, Stacey, Mazzeo, Daniela, Goult, Benjamin T., Gingras, Alexandre R., Pritchard, Catrin A., Critchley, David R., Monkley, Susan J.
Publicado 2010

Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome

por Venkatraman Girija, Umakhanth, Furze, Christopher M, Gingras, Alexandre R, Yoshizaki, Takayuki, Ohtani, Katsuki, Marshall, Jamie E, Wallis, A Katrine, Schwaeble, Wilhelm J, El-Mezgueldi, Mohammed, Mitchell, Daniel A, Moody, Peter CE, Wakamiya, Nobutaka, Wallis, Russell
Publicado 2015

Inhibition of the HEG1–KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells

por Lopez‐Ramirez, Miguel Alejandro, McCurdy, Sara, Li, Wenqing, Haynes, Mark K., Hale, Preston, Francisco, Karol, Oukoloff, Killian, Bautista, Matthew, Choi, Chelsea H.J., Sun, Hao, Gongol, Brendan, Shyy, John Y., Ballatore, Carlo, Sklar, Larry A., Gingras, Alexandre R.
Publicado 2021

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function

por Sun, Hao, Lee, Ho-Sup, Kim, Sarah Hyun-Ji, de Lima, Mikhael Fernandes, Gingras, Alexandre R., Du, Qinyi, McLaughlin, Wilma, Ablack, Jailail, Lopez-Ramirez, Miguel A., Lagarrigue, Frederic, Fan, Zhichao, Chang, John T., VanDyke, Derek, Spangler, Jamie B., Ginsberg, Mark H.
Publicado 2023

Structural Determinants of Integrin Binding to the Talin Rod

por Gingras, Alexandre R., Ziegler, Wolfgang H., Bobkov, Andrey A., Joyce, M. Gordon, Fasci, Domenico, Himmel, Mirko, Rothemund, Sven, Ritter, Anett, Grossmann, J. Günter, Patel, Bipin, Bate, Neil, Goult, Benjamin T., Emsley, Jonas, Barsukov, Igor L., Roberts, Gordon C. K., Liddington, Robert C., Ginsberg, Mark H., Critchley, David R.
Publicado 2009