Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development

por Barrett, Neil A., Malouf, Camille, Kapeni, Chrysa, Bacon, Wendi A., Giotopoulos, George, Jacobsen, Sten Eirik W., Huntly, Brian J., Ottersbach, Katrin
Publicado 2016

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/−) leukemia

por van der Weyden, Louise, Giotopoulos, George, Wong, Kim, Rust, Alistair G., Robles-Espinoza, Carla Daniela, Osaki, Hikari, Huntly, Brian J., Adams, David J.
Publicado 2015

Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

por Domingues, Ana Filipa, Kulkarni, Rashmi, Giotopoulos, George, Gupta, Shikha, Vinnenberg, Laura, Arede, Liliana, Foerner, Elena, Khalili, Mitra, Adao, Rita Romano, Johns, Ayona, Tan, Shengjiang, Zeka, Keti, Huntly, Brian J, Prabakaran, Sudhakaran, Pina, Cristina
Publicado 2020

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

por Basilico, Silvia, Wang, Xiaonan, Kennedy, Alison, Tzelepis, Konstantinos, Giotopoulos, George, Kinston, Sarah J., Quiros, Pedro M., Wong, Kim, Adams, David J., Carnevalli, Larissa S., Huntly, Brian J. P., Vassiliou, George S., Calero-Nieto, Fernando J., Göttgens, Berthold
Publicado 2020

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression

por Giotopoulos, George, van der Weyden, Louise, Osaki, Hikari, Rust, Alistair G., Gallipoli, Paolo, Meduri, Eshwar, Horton, Sarah J., Chan, Wai-In, Foster, Donna, Prinjha, Rab K., Pimanda, John E., Tenen, Daniel G., Vassiliou, George S., Koschmieder, Steffen, Adams, David J., Huntly, Brian J.P.
Publicado 2015

KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia

por Arede, Liliana, Foerner, Elena, Wind, Selinde, Kulkarni, Rashmi, Domingues, Ana Filipa, Giotopoulos, George, Kleinwaechter, Svenja, Mollenhauer-Starkl, Maximilian, Davison, Holly, Chandru, Aditya, Asby, Ryan, Samarista, Ralph, Gupta, Shikha, Forte, Dorian, Curti, Antonio, Scheer, Elisabeth, Huntly, Brian J. P., Tora, Laszlo, Pina, Cristina
Publicado 2022

Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis

por Gupta, Shikha, Dovey, Oliver M., Domingues, Ana Filipa, Cyran, Oliwia W., Cash, Caitlin M., Giotopoulos, George, Rak, Justyna, Cooper, Jonathan, Gozdecka, Malgorzata, Dijkhuis, Liza, Asby, Ryan J., Al-Jabery, Noor, Hernandez-Hernandez, Victor, Prabakaran, Sudhakaran, Huntly, Brian J., Vassiliou, George S., Pina, Cristina
Publicado 2022

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML

por Basheer, Faisal, Giotopoulos, George, Meduri, Eshwar, Yun, Haiyang, Mazan, Milena, Sasca, Daniel, Gallipoli, Paolo, Marando, Ludovica, Gozdecka, Malgorzata, Asby, Ryan, Sheppard, Olivia, Dudek, Monika, Bullinger, Lars, Döhner, Hartmut, Dillon, Richard, Freeman, Sylvie, Ottmann, Oliver, Burnett, Alan, Russell, Nigel, Papaemmanuil, Elli, Hills, Robert, Campbell, Peter, Vassiliou, George S., Huntly, Brian J.P.
Publicado 2019

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

por Woodley, Keith, Dillingh, Laura S., Giotopoulos, George, Madrigal, Pedro, Rattigan, Kevin M., Philippe, Céline, Dembitz, Vilma, Magee, Aoife M. S., Asby, Ryan, van de Lagemaat, Louie N., Mapperley, Christopher, James, Sophie C., Prehn, Jochen H. M., Tzelepis, Konstantinos, Rouault-Pierre, Kevin, Vassiliou, George S., Kranc, Kamil R., Helgason, G. Vignir, Huntly, Brian J. P., Gallipoli, Paolo
Publicado 2023

Mutational synergy during leukemia induction remodels chromatin accessibility, modification and 3-Dimensional DNA topology to alter gene expression

por Yun, Haiyang, Narayan, Nisha, Vohra, Shabana, Giotopoulos, George, Mupo, Annalisa, Madrigal, Pedro, Sasca, Daniel, Lara-Astiaso, David, Horton, Sarah J., Agrawal-Singh, Shuchi, Meduri, Eshwar, Basheer, Faisal, Marando, Ludovica, Gozdecka, Malgorzata, Dovey, Oliver M., Castillo-Venzor, Aracely, Wang, Xiaonan, Gallipoli, Paolo, Müller-Tidow, Carsten, Osborne, Cameron S., Vassiliou, George S., Huntly, Brian J. P.
Publicado 2021

In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis

por Lara-Astiaso, David, Goñi-Salaverri, Ainhoa, Mendieta-Esteban, Julen, Narayan, Nisha, Del Valle, Cynthia, Gross, Torsten, Giotopoulos, George, Beinortas, Tumas, Navarro-Alonso, Mar, Aguado-Alvaro, Laura Pilar, Zazpe, Jon, Marchese, Francesco, Torrea, Natalia, Calvo, Isabel A., Lopez, Cecile K., Alignani, Diego, Lopez, Aitziber, Saez, Borja, Taylor-King, Jake P., Prosper, Felipe, Fortelny, Nikolaus, Huntly, Brian J. P.
Publicado 2023

Novel and Rare Fusion Transcripts Involving Transcription Factors and Tumor Suppressor Genes in Acute Myeloid Leukemia

por Padella, Antonella, Simonetti, Giorgia, Paciello, Giulia, Giotopoulos, George, Baldazzi, Carmen, Righi, Simona, Ghetti, Martina, Stengel, Anna, Guadagnuolo, Viviana, De Tommaso, Rossella, Papayannidis, Cristina, Robustelli, Valentina, Franchini, Eugenia, Ghelli Luserna di Rorà, Andrea, Ferrari, Anna, Fontana, Maria Chiara, Bruno, Samantha, Ottaviani, Emanuela, Soverini, Simona, Storlazzi, Clelia Tiziana, Haferlach, Claudia, Sabattini, Elena, Testoni, Nicoletta, Iacobucci, Ilaria, Huntly, Brian J. P., Ficarra, Elisa, Martinelli, Giovanni
Publicado 2019

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

por Horton, Sarah J., Giotopoulos, George, Yun, Haiyang, Vohra, Shabana, Sheppard, Olivia, Bashford-Rogers, Rachael, Rashid, Mamunur, Clipson, Alexandra, Chan, Wai-In, Sasca, Daniel, Yiangou, Loukia, Osaki, Hikari, Basheer, Faisal, Gallipoli, Paolo, Burrows, Natalie, Erdem, Aysegul, Sybirna, Anastasiya, Foerster, Sarah, Zhao, Wanfeng, Sustic, Tonci, Harrison, Anna Petrunkina, Laurenti, Elisa, Okosun, Jessica, Hodson, Daniel, Wright, Penny, Smith, Ken G., Maxwell, Patrick, Fitzgibbon, Jude, Du, Ming Q., Adams, David J., Huntly, Brian J.P
Publicado 2017