First‐in‐human study of deucravacitinib: A selective, potent, allosteric small‐molecule inhibitor of tyrosine kinase 2

por Catlett, Ian M., Aras, Urvi, Hansen, Lars, Liu, Yali, Bei, Di, Girgis, Ihab G., Murthy, Bindu
Publicado 2022

Pharmacokinetics and Safety of the Tyrosine Kinase 2 Inhibitor Deucravacitinib in Healthy Chinese Subjects

por Jing, Shan, Lin, Yang, Dockens, Randy, Marchisin, David, He, Bing, Girgis, Ihab G., Chimalakonda, Anjaneya, Murthy, Bindu, Aras, Urvi
Publicado 2023

Safety, pharmacokinetics and pharmacodynamics of branebrutinib (BMS‐986195), a covalent, irreversible inhibitor of Bruton's tyrosine kinase: Randomised phase I, placebo‐controlled...

por Catlett, Ian M., Nowak, Miroslawa, Kundu, Sudeep, Zheng, Naiyu, Liu, Ang, He, Bing, Girgis, Ihab G., Grasela, Dennis M.
Publicado 2020

Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants t...

por Cai, Weiguo, Leil, Tarek A., Gibiansky, Leonid, Krishna, Murli, Zhang, Hongwei, Gu, Huidong, Sun, Huadong, Throup, John, Banerjee, Subhashis, Girgis, Ihab
Publicado 2020

Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors

por Chimalakonda, Anjaneya, Burke, James, Cheng, Lihong, Catlett, Ian, Tagen, Michael, Zhao, Qihong, Patel, Aditya, Shen, Jun, Girgis, Ihab G., Banerjee, Subhashis, Throup, John
Publicado 2021

Lack of Electrocardiographic Effects of Deucravacitinib in Healthy Subjects

por Chimalakonda, Anjaneya, Singhal, Shalabh, Darbenzio, Raymond, Dockens, Randy, Marchisin, David, Banerjee, Subhashis, Girgis, Ihab G., Throup, John, He, Bing, Aras, Urvi, Murthy, Bindu
Publicado 2022

Population Pharmacokinetic Analysis of BMS‐986166, a Novel Selective Sphingosine‐1‐Phosphate‐1 Receptor Modulator, and Exposure‐Response Assessment of Lymphocyte Counts and Heart R...

por Bihorel, Sébastien, Singhal, Shalabh, Shevell, Diane, Sun, Huadong, Xie, Jenny, Basdeo, Shenita, Liu, Ang, Dutta, Santanu, Ludwig, Elizabeth, Huang, Hannah, Lin, Kuan‐ju, Fura, Aberra, Throup, John, Girgis, Ihab G.
Publicado 2020