Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

por Straimer, Judith, Gnädig, Nina F., Stokes, Barbara H., Ehrenberger, Michelle, Crane, Audrey A., Fidock, David A.
Publicado 2017

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

por Beaucourt, Stéphanie, Bordería, Antonio V., Coffey, Lark L., Gnädig, Nina F., Sanz-Ramos, Marta, Beeharry, Yasnee, Vignuzzi, Marco
Publicado 2011

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

por Levi, Laura I., Gnädig, Nina F., Beaucourt, Stéphanie, McPherson, Malia J., Baron, Bruno, Arnold, Jamie J., Vignuzzi, Marco
Publicado 2010

Mother-to-child transmission of HTLV-1:in vitro study of HTLV-1 passage across a tight human epithelial barrier

por Martin-Latil, Sandra, Gnädig, Nina, Mallet, Adeline, Prevost, Marie-Christine, Desdouits, Marion, Schwartz, Olivier, Gessain, Antoine, Ozden, Simona, Ceccaldi, Pierre-Emmanuel
Publicado 2011

Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance

por Paloque, Lucie, Coppée, Romain, Stokes, Barbara H., Gnädig, Nina F., Niaré, Karamoko, Augereau, Jean-Michel, Fidock, David A., Clain, Jérôme, Benoit-Vical, Françoise
Publicado 2022

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

por Veiga, M. Isabel, Dhingra, Satish K., Henrich, Philipp P., Straimer, Judith, Gnädig, Nina, Uhlemann, Anne-Catrin, Martin, Rowena E., Lehane, Adele M., Fidock, David A.
Publicado 2016

Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype

por Bordería, Antonio V., Isakov, Ofer, Moratorio, Gonzalo, Henningsson, Rasmus, Agüera-González, Sonia, Organtini, Lindsey, Gnädig, Nina F., Blanc, Hervé, Alcover, Andrés, Hafenstein, Susan, Fontes, Magnus, Shomron, Noam, Vignuzzi, Marco
Publicado 2015

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

por Harding, Clare R., Sidik, Saima M., Petrova, Boryana, Gnädig, Nina F., Okombo, John, Herneisen, Alice L., Ward, Kurt E., Markus, Benedikt M., Boydston, Elizabeth A., Fidock, David A., Lourido, Sebastian
Publicado 2020

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

por Mok, Sachel, Stokes, Barbara H., Gnädig, Nina F., Ross, Leila S., Yeo, Tomas, Amaratunga, Chanaki, Allman, Erik, Solyakov, Lev, Bottrill, Andrew R., Tripathi, Jaishree, Fairhurst, Rick M., Llinás, Manuel, Bozdech, Zbynek, Tobin, Andrew B., Fidock, David A.
Publicado 2021

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

por Gnädig, Nina F., Stokes, Barbara H., Edwards, Rachel L., Kalantarov, Gavreel F., Heimsch, Kim C., Kuderjavy, Michal, Crane, Audrey, Lee, Marcus C. S., Straimer, Judith, Becker, Katja, Trakht, Ilya N., Odom John, Audrey R., Mok, Sachel, Fidock, David A.
Publicado 2020

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

por Dogovski, Con, Xie, Stanley C., Burgio, Gaetan, Bridgford, Jess, Mok, Sachel, McCaw, James M., Chotivanich, Kesinee, Kenny, Shannon, Gnädig, Nina, Straimer, Judith, Bozdech, Zbynek, Fidock, David A., Simpson, Julie A., Dondorp, Arjen M., Foote, Simon, Klonis, Nectarios, Tilley, Leann
Publicado 2015

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiol...

por Gabryszewski, Stanislaw J., Dhingra, Satish K., Combrinck, Jill M., Lewis, Ian A., Callaghan, Paul S., Hassett, Matthew R., Siriwardana, Amila, Henrich, Philipp P., Lee, Andrew H., Gnädig, Nina F., Musset, Lise, Llinás, Manuel, Egan, Timothy J., Roepe, Paul D., Fidock, David A.
Publicado 2016

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

por LaMonte, Gregory M., Rocamora, Frances, Marapana, Danushka S., Gnädig, Nina F., Ottilie, Sabine, Luth, Madeline R., Worgall, Tilla S., Goldgof, Gregory M., Mohunlal, Roxanne, Santha Kumar, T. R., Thompson, Jennifer K., Vigil, Edgar, Yang, Jennifer, Hutson, Dylan, Johnson, Trevor, Huang, Jianbo, Williams, Roy M., Zou, Bing Yu, Cheung, Andrea L., Kumar, Prianka, Egan, Timothy J., Lee, Marcus C. S., Siegel, Dionicio, Cowman, Alan F., Fidock, David A., Winzeler, Elizabeth A.
Publicado 2020

A broad analysis of resistance development in the malaria parasite

por Corey, Victoria C., Lukens, Amanda K., Istvan, Eva S., Lee, Marcus C. S., Franco, Virginia, Magistrado, Pamela, Coburn-Flynn, Olivia, Sakata-Kato, Tomoyo, Fuchs, Olivia, Gnädig, Nina F., Goldgof, Greg, Linares, Maria, Gomez-Lorenzo, Maria G., De Cózar, Cristina, Lafuente-Monasterio, Maria Jose, Prats, Sara, Meister, Stephan, Tanaseichuk, Olga, Wree, Melanie, Zhou, Yingyao, Willis, Paul A., Gamo, Francisco-Javier, Goldberg, Daniel E., Fidock, David A., Wirth, Dyann F., Winzeler, Elizabeth A.
Publicado 2016

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

por Stokes, Barbara H, Dhingra, Satish K, Rubiano, Kelly, Mok, Sachel, Straimer, Judith, Gnädig, Nina F, Deni, Ioanna, Schindler, Kyra A, Bath, Jade R, Ward, Kurt E, Striepen, Josefine, Yeo, Tomas, Ross, Leila S, Legrand, Eric, Ariey, Frédéric, Cunningham, Clark H, Souleymane, Issa M, Gansané, Adama, Nzoumbou-Boko, Romaric, Ndayikunda, Claudette, Kabanywanyi, Abdunoor M, Uwimana, Aline, Smith, Samuel J, Kolley, Olimatou, Ndounga, Mathieu, Warsame, Marian, Leang, Rithea, Nosten, François, Anderson, Timothy JC, Rosenthal, Philip J, Ménard, Didier, Fidock, David A
Publicado 2021

A G358S mutation in the Plasmodium falciparum Na(+) pump PfATP4 confers clinically-relevant resistance to cipargamin

por Qiu, Deyun, Pei, Jinxin V., Rosling, James E. O., Thathy, Vandana, Li, Dongdi, Xue, Yi, Tanner, John D., Penington, Jocelyn Sietsma, Aw, Yi Tong Vincent, Aw, Jessica Yi Han, Xu, Guoyue, Tripathi, Abhai K., Gnadig, Nina F., Yeo, Tomas, Fairhurst, Kate J., Stokes, Barbara H., Murithi, James M., Kümpornsin, Krittikorn, Hasemer, Heath, Dennis, Adelaide S. M., Ridgway, Melanie C., Schmitt, Esther K., Straimer, Judith, Papenfuss, Anthony T., Lee, Marcus C. S., Corry, Ben, Sinnis, Photini, Fidock, David A., van Dooren, Giel G., Kirk, Kiaran, Lehane, Adele M.
Publicado 2022

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

por Murithi, James M., Deni, Ioanna, Pasaje, Charisse Flerida A., Okombo, John, Bridgford, Jessica L., Gnädig, Nina F., Edwards, Rachel L., Yeo, Tomas, Mok, Sachel, Burkhard, Anna Y., Coburn-Flynn, Olivia, Istvan, Eva S., Sakata-Kato, Tomoyo, Gomez-Lorenzo, Maria G., Cowell, Annie N., Wicht, Kathryn J., Le Manach, Claire, Kalantarov, Gavreel F., Dey, Sumanta, Duffey, Maëlle, Laleu, Benoît, Lukens, Amanda K., Ottilie, Sabine, Vanaerschot, Manu, Trakht, Ilya N., Gamo, Francisco-Javier, Wirth, Dyann F., Goldberg, Daniel E., Odom John, Audrey R., Chibale, Kelly, Winzeler, Elizabeth A., Niles, Jacquin C., Fidock, David A.
Publicado 2022

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

por Le Bihan, Amélie, de Kanter, Ruben, Angulo-Barturen, Iñigo, Binkert, Christoph, Boss, Christoph, Brun, Reto, Brunner, Ralf, Buchmann, Stephan, Burrows, Jeremy, Dechering, Koen J., Delves, Michael, Ewerling, Sonja, Ferrer, Santiago, Fischli, Christoph, Gamo–Benito, Francisco Javier, Gnädig, Nina F., Heidmann, Bibia, Jiménez-Díaz, María Belén, Leroy, Didier, Martínez, Maria Santos, Meyer, Solange, Moehrle, Joerg J., Ng, Caroline L., Noviyanti, Rintis, Ruecker, Andrea, Sanz, Laura María, Sauerwein, Robert W., Scheurer, Christian, Schleiferboeck, Sarah, Sinden, Robert, Snyder, Christopher, Straimer, Judith, Wirjanata, Grennady, Marfurt, Jutta, Price, Ric N., Weller, Thomas, Fischli, Walter, Fidock, David A., Clozel, Martine, Wittlin, Sergio
Publicado 2016

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

por Cowell, Annie N., Istvan, Eva S., Lukens, Amanda K., Gomez-Lorenzo, Maria G., Vanaerschot, Manu, Sakata-Kato, Tomoyo, Flannery, Erika L., Magistrado, Pamela, Owen, Edward, Abraham, Matthew, LaMonte, Gregory, Painter, Heather J., Williams, Roy M., Franco, Virginia, Linares, Maria, Arriaga, Ignacio, Bopp, Selina, Corey, Victoria C., Gnädig, Nina F., Coburn-Flynn, Olivia, Reimer, Christin, Gupta, Purva, Murithi, James M., Moura, Pedro A., Fuchs, Olivia, Sasaki, Erika, Kim, Sang W., Teng, Christine H., Wang, Lawrence T., Akidil, Aslı, Adjalley, Sophie, Willis, Paul A., Siege, Dionicio, Tanaseichuk, Olga, Zhong, Yang, Zhou, Yingyao, Llinás, Manuel, Ottilie, Sabine, Gamo, Francisco-Javier, Lee, Marcus C. S., Goldberg, Daniel E., Fidock, David A., Wirth, Dyann F., Winzeler, Elizabeth A.
Publicado 2018

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

por O'Neill, Paul M., Amewu, Richard K., Charman, Susan A., Sabbani, Sunil, Gnädig, Nina F., Straimer, Judith, Fidock, David A., Shore, Emma R., Roberts, Natalie L., Wong, Michael H.-L., Hong, W. David, Pidathala, Chandrakala, Riley, Chris, Murphy, Ben, Aljayyoussi, Ghaith, Gamo, Francisco Javier, Sanz, Laura, Rodrigues, Janneth, Cortes, Carolina Gonzalez, Herreros, Esperanza, Angulo-Barturén, Iñigo, Jiménez-Díaz, María Belén, Bazaga, Santiago Ferrer, Martínez-Martínez, María Santos, Campo, Brice, Sharma, Raman, Ryan, Eileen, Shackleford, David M., Campbell, Simon, Smith, Dennis A., Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N., Marfurt, Jutta, Palmer, Michael J., Copple, Ian M., Mercer, Amy E., Ruecker, Andrea, Delves, Michael J., Sinden, Robert E., Siegl, Peter, Davies, Jill, Rochford, Rosemary, Kocken, Clemens H. M., Zeeman, Anne-Marie, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.
Publicado 2017