E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer

por Figueiredo, Joana, Melo, Soraia, Gamet, Kimberley, Godwin, Tanis, Seixas, Susana, Sanches, João M., Guilford, Parry, Seruca, Raquel
Publicado 2018

Loss of E-Cadherin Leads to Druggable Vulnerabilities in Sphingolipid Metabolism and Vesicle Trafficking

por Brew, Tom, Bougen-Zhukov, Nicola, Mitchell, Wilson, Decourtye, Lyvianne, Schulpen, Emily, Nouri, Yasmin, Godwin, Tanis, Guilford, Parry
Publicado 2021

E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors

por Decourtye-Espiard, Lyvianne, Bougen-Zhukov, Nicola, Godwin, Tanis, Brew, Tom, Schulpen, Emily, Black, Michael A., Guilford, Parry
Publicado 2021

E-Cadherin-Deficient Cells Are Sensitive to the Multikinase Inhibitor Dasatinib

por Bougen-Zhukov, Nicola, Decourtye-Espiard, Lyvianne, Mitchell, Wilson, Redpath, Kieran, Perkinson, Jacqui, Godwin, Tanis, Black, Michael A., Guilford, Parry
Publicado 2022

Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells

por Bougen-Zhukov, Nicola, Nouri, Yasmin, Godwin, Tanis, Taylor, Megan, Hakkaart, Christopher, Single, Andrew, Brew, Tom, Permina, Elizabeth, Chen, Augustine, Black, Michael A., Guilford, Parry
Publicado 2019

E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition

por Chen, Augustine, Beetham, Henry, Black, Michael A, Priya, Rashmi, Telford, Bryony J, Guest, Joanne, Wiggins, George A R, Godwin, Tanis D, Yap, Alpha S, Guilford, Parry J
Publicado 2014

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function

por Godwin, Tanis D., Kelly, S. Thomas, Brew, Tom P., Bougen-Zhukov, Nicola M., Single, Andrew B., Chen, Augustine, Stylianou, Cassie E., Harris, Lawrence D., Currie, Sophie K., Telford, Bryony J., Beetham, Henry G., Evans, Gary B., Black, Michael A., Guilford, Parry J.
Publicado 2018