Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease

por Jacobse, Justin, Li, Jing, Rings, Edmond H. H. M., Samsom, Janneke N., Goettel, Jeremy A.
Publicado 2021

HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice

por Tyagi, Rajeev K., Jacobse, Justin, Li, Jing, Allaman, Margret M., Otipoby, Kevin L., Sampson, Erik R., Wilson, Keith T., Goettel, Jeremy A.
Publicado 2021

Identification of a functional peptide of a probiotic bacterium-derived protein for the sustained effect on preventing colitis

por Kaur, Harpreet, Ali, Syed Azmal, Short, Sarah P., Williams, Christopher S., Goettel, Jeremy A., Washington, M. Kay, Peek, Richard M., Acra, Sari A., Yan, Fang
Publicado 2023

MTGR1 is required to maintain small intestinal stem cell populations

por Williams, Christopher, Brown, Rachel, Zhao, Yue, Wang, Jing, Chen, Zhengyi, Blunt, Koral, Pilat, Jennifer, Parang, Bobak, Choksi, Yash, Lau, Ken, Hiebert, Scott, Short, Sarah, Jacobse, Justin, Xu, Yanwen, Yang, Yilin, Goettel, Jeremy
Publicado 2023

Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity

por Latour, Yvonne L., Allaman, Margaret M., Barry, Daniel P., Smith, Thaddeus M., Williams, Kamery J., McNamara, Kara M., Jacobse, Justin, Goettel, Jeremy A., Delgado, Alberto G., Piazuelo, M. Blanca, Zhao, Shilin, Gobert, Alain P., Wilson, Keith T.
Publicado 2023

CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types

por Nelms, Bradlee D., Waldron, Levi, Barrera, Luis A., Weflen, Andrew W., Goettel, Jeremy A., Guo, Guoji, Montgomery, Robert K., Neutra, Marian R., Breault, David T., Snapper, Scott B., Orkin, Stuart H., Bulyk, Martha L., Huttenhower, Curtis, Lencer, Wayne I.
Publicado 2016

Intestinal Inflammation Promotes MDL-1(+) Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss

por Peek, Christopher T., Ford, Caleb A., Eichelberger, Kara R., Jacobse, Justin, Torres, Teresa P., Maseda, Damian, Latour, Yvonne L., Piazuelo, M. Blanca, Johnson, Joshua R., Byndloss, Mariana X., Wilson, Keith T., Rathmell, Jeffrey C., Goettel, Jeremy A., Cassat, James E.
Publicado 2022

Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

por Redhu, Naresh S, Bakthavatchalu, Vasudevan, Conaway, Evan A, Shouval, Dror S, Tsou, Amy, Goettel, Jeremy A, Biswas, Amlan, Wang, Chuanwu, Field, Michael, Muller, Werner, Bleich, Andre, Li, Ning, Gerber, Georg K, Bry, Lynn, Fox, James G, Snapper, Scott B, Horwitz, Bruce H
Publicado 2017

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

por Biswas, Amlan, Shouval, Dror S., Griffith, Alexandra, Goettel, Jeremy A., Field, Michael, Kang, Yu Hui, Konnikova, Liza, Janssen, Erin, Redhu, Naresh Singh, Thrasher, Adrian J., Chatila, Talal, Kuchroo, Vijay K., Geha, Raif S, Notarangelo, Luigi D., Pai, Sung-Yun, Horwitz, Bruce H., Snapper, Scott B.
Publicado 2018

SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions

por Pilat, Jennifer M., Brown, Rachel E., Chen, Zhengyi, Berle, Nathaniel J., Othon, Adrian P., Washington, M. Kay, Anant, Shruti A., Kurokawa, Suguru, Ng, Victoria H., Thompson, Joshua J., Jacobse, Justin, Goettel, Jeremy A., Lee, Ethan, Choksi, Yash A., Lau, Ken S., Short, Sarah P., Williams, Christopher S.
Publicado 2023

Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis

por Ryzhakov, Grigory, West, Nathaniel R., Franchini, Fanny, Clare, Simon, Ilott, Nicholas E., Sansom, Stephen N., Bullers, Samuel J., Pearson, Claire, Costain, Alice, Vaughan-Jackson, Alun, Goettel, Jeremy A., Ermann, Joerg, Horwitz, Bruce H., Buti, Ludovico, Lu, Xin, Mukhopadhyay, Subhankar, Snapper, Scott B., Powrie, Fiona
Publicado 2018

Haematopoietic stem and progenitor cells from human pluripotent stem cells

por Sugimura, Ryohichi, Jha, Deepak Kumar, Han, Areum, Soria-Valles, Clara, da Rocha, Edroaldo Lummertz, Lu, Yi-Fen, Goettel, Jeremy A., Serrao, Erik, Rowe, R. Grant, Malleshaiah, Mohan, Wong, Irene, Sousa, Patricia, Zhu, Ted N., Ditadi, Andrea, Keller, Gordon, Engelman, Alan N., Snapper, Scott B., Doulatov, Sergei, Daley, George Q.
Publicado 2017

Eosinophils Exert Antitumorigenic Effects in the Development of Esophageal Squamous Cell Carcinoma

por Jacobse, Justin, Aziz, Zaryab, Sun, Lili, Chaparro, Jasmine, Pilat, Jennifer M., Kwag, Aaron, Buendia, Matthew, Wimbiscus, Mae, Nasu, Motomi, Saito, Tsuyoshi, Mine, Shinji, Orita, Hajime, Revetta, Frank, Short, Sarah P., Kay Washington, M., Hiremath, Girish, Gibson, Michael K., Coburn, Lori A., Koyama, Tatsuki, Goettel, Jeremy A., Williams, Christopher S., Choksi, Yash A.
Publicado 2023

Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation

por Tsou, Amy M., Goettel, Jeremy A., Bao, Bin, Biswas, Amlan, Kang, Yu Hui, Redhu, Naresh S., Peng, Kaiyue, Putzel, Gregory G., Saltzman, Jeffrey, Kelly, Ryan, Gringauz, Jordan, Barends, Jared, Hatazaki, Mai, Frei, Sandra M., Emani, Rohini, Huang, Ying, Shen, Zeli, Fox, James G., Glickman, Jonathan N., Horwitz, Bruce H., Snapper, Scott B.
Publicado 2021

Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model

por Goettel, Jeremy A., Kotlarz, Daniel, Emani, Rohini, Canavan, James B., Konnikova, Liza, Illig, David, Frei, Sandra M., Field, Michael, Kowalik, Matthew, Peng, Kaiyue, Gringauz, Jordan, Mitsialis, Vanessa, Wall, Sarah M., Tsou, Amy, Griffith, Alexandra E., Huang, Ying, Friedman, Joshua R., Towne, Jennifer E., Plevy, Scott E., O’Hara Hall, Aisling, Snapper, Scott B.
Publicado 2019

MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors

por Brown, Rachel E., Jacobse, Justin, Anant, Shruti A., Blunt, Koral M., Chen, Bob, Vega, Paige N., Jones, Chase T., Pilat, Jennifer M., Revetta, Frank, Gorby, Aidan H., Stengel, Kristy R., Choksi, Yash A., Palin, Kimmo, Piazuelo, M. Blanca, Washington, Mary Kay, Lau, Ken S., Goettel, Jeremy A., Hiebert, Scott W., Short, Sarah P., Williams, Christopher S.
Publicado 2022

Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells

por Jacobse, Justin, Brown, Rachel E., Li, Jing, Pilat, Jennifer M., Pham, Ly, Short, Sarah P., Peek, Christopher T., Rolong, Andrea, Washington, M. Kay, Martinez-Barricarte, Ruben, Byndloss, Mariana X., Shelton, Catherine, Markle, Janet G., Latour, Yvonne L., Allaman, Margaret M., Cassat, James E., Wilson, Keith T., Choksi, Yash A., Williams, Christopher S., Lau, Ken S., Flynn, Charles R., Casanova, Jean-Laurent, Rings, Edmond H.H.M., Samsom, Janneke N., Goettel, Jeremy A.
Publicado 2023

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

por Chen, Bob, Scurrah, Cherie’ R., McKinley, Eliot T., Simmons, Alan J., Ramirez-Solano, Marisol A., Zhu, Xiangzhu, Markham, Nicholas O., Heiser, Cody N., Vega, Paige N., Rolong, Andrea, Kim, Hyeyon, Sheng, Quanhu, Drewes, Julia L., Zhou, Yuan, Southard-Smith, Austin N., Xu, Yanwen, Ro, James, Jones, Angela L., Revetta, Frank, Berry, Lynne D., Niitsu, Hiroaki, Islam, Mirazul, Pelka, Karin, Hofree, Matan, Chen, Jonathan H., Sarkizova, Siranush, Ng, Kimmie, Giannakis, Marios, Boland, Genevieve M., Aguirre, Andrew J., Anderson, Ana C., Rozenblatt-Rosen, Orit, Regev, Aviv, Hacohen, Nir, Kawasaki, Kenta, Sato, Toshiro, Goettel, Jeremy A., Grady, William M., Zheng, Wei, Washington, M. Kay, Cai, Qiuyin, Sears, Cynthia L., Goldenring, James R., Franklin, Jeffrey L., Su, Timothy, Huh, Won Jae, Vandekar, Simon, Roland, Joseph T., Liu, Qi, Coffey, Robert J., Shrubsole, Martha J., Lau, Ken S.
Publicado 2021