Optimized Administration of the M(4) PAM VU0467154 Demonstrates Broad Efficacy, but Limited Effective Concentrations in Mecp2(+/–) Mice

por Cikowski, Jakub, Holt, Calista, Arthur, Bright, Smith, Mackenzie, Gonzalez, Sonia, Lindsley, Craig W., Niswender, Colleen M., Gogliotti, Rocco G.
Publicado 2022

mGlu(5) Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu(5)-Endocannabinoid Signaling

por Xiang, Zixiu, Lv, Xiaohui, Maksymetz, James, Stansley, Branden J., Ghoshal, Ayan, Gogliotti, Rocco G., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey
Publicado 2019

Profiling beneficial and potential adverse effects of MeCP2 overexpression in a hypomorphic Rett syndrome mouse model

por Vermudez, Sheryl Anne D., Gogliotti, Rocco G., Arthur, Bright, Buch, Aditi, Morales, Clarissa, Moxley, Yuta, Rajpal, Hemangi, Conn, P. Jeffrey, Niswender, Colleen M.
Publicado 2021

Discovery, Characterization, and Structure–Activity Relationships of an Inhibitor of Inward Rectifier Potassium (Kir) Channels with Preference for Kir2.3, Kir3.X, and Kir7.1

por Raphemot, Rene, Lonergan, Daniel F., Nguyen, Thuy T., Utley, Thomas, Lewis, L. Michelle, Kadakia, Rishin, Weaver, C. David, Gogliotti, Rocco, Hopkins, Corey, Lindsley, Craig W., Denton, Jerod S.
Publicado 2011

Clinical and Preclinical Evidence for M(1) Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome

por Smith, Mackenzie, Arthur, Bright, Cikowski, Jakub, Holt, Calista, Gonzalez, Sonia, Fisher, Nicole M., Vermudez, Sheryl Anne D., Lindsley, Craig W., Niswender, Colleen M., Gogliotti, Rocco G.
Publicado 2022

High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

por He, Shihan, Senter, Timothy J., Pollock, Jonathan, Han, Changho, Upadhyay, Sunil Kumar, Purohit, Trupta, Gogliotti, Rocco D., Lindsley, Craig W., Cierpicki, Tomasz, Stauffer, Shaun R., Grembecka, Jolanta
Publicado 2014

Eliciting Renal Failure in Mosquitoes with a Small-Molecule Inhibitor of Inward-Rectifying Potassium Channels

por Raphemot, Rene, Rouhier, Matthew F., Hopkins, Corey R., Gogliotti, Rocco D., Lovell, Kimberly M., Hine, Rebecca M., Ghosalkar, Dhairyasheel, Longo, Anthony, Beyenbach, Klaus W., Denton, Jerod S., Piermarini, Peter M.
Publicado 2013

A GRM7 mutation associated with developmental delay reduces mGlu(7) expression and produces neurological phenotypes

por Fisher, Nicole M., AlHashim, Aqeela, Buch, Aditi B., Badivuku, Hana, Samman, Manar M., Weiss, Kelly M., Cestero, Gabriela I., Does, Mark D., Rook, Jerri M., Lindsley, Craig W., Conn, P. Jeffrey, Gogliotti, Rocco G., Niswender, Colleen M.
Publicado 2021

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

por Aho, Erin R., Wang, Jing, Gogliotti, Rocco D., Howard, Gregory C., Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D., Cheng, Ken, Lorey, Shelly L., Lu, Bin, Wenzel, Sabine, Foshage, Audra M., Alvarado, Joseph, Wang, Feng, Shaw, J. Grace, Zhao, Bin, Weissmiller, April M., Thomas, Lance R., Vakoc, Christopher R., Hall, Matthew D., Hiebert, Scott W., Liu, Qi, Stauffer, Shaun R., Fesik, Stephen W., Tansey, William P.
Publicado 2019