TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NF-κB activation

por YAMAMOTO, Mizuki, GOHDA, Jin, AKIYAMA, Taishin, INOUE, Jun-ichiro
Publicado 2021

Predicting Novel Features of Toll-Like Receptor 3 Signaling in Macrophages

por Helmy, Mohamed, Gohda, Jin, Inoue, Jun-ichiro, Tomita, Masaru, Tsuchiya, Masa, Selvarajoo, Kumar
Publicado 2009

Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88

por Into, Takeshi, Horie, Toshi, Inomata, Megumi, Gohda, Jin, Inoue, Jun-ichiro, Murakami, Yukitaka, Niida, Shumpei
Publicado 2017

BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1

por Gohda, Jin, Suzuki, Kazuo, Liu, Kai, Xie, Xialin, Takeuchi, Hiroaki, Inoue, Jun-ichiro, Kawaguchi, Yasushi, Ishida, Takaomi
Publicado 2018

Signaling Flux Redistribution at Toll-Like Receptor Pathway Junctions

por Selvarajoo, Kumar, Takada, Yasunari, Gohda, Jin, Helmy, Mohamed, Akira, Shizuo, Tomita, Masaru, Tsuchiya, Masa, Inoue, Jun-ichiro, Matsuo, Koichi
Publicado 2008

Discovery of New Fusion Inhibitor Peptides against SARS-CoV-2 by Targeting the Spike S2 Subunit

por Kandeel, Mahmoud, Yamamoto, Mizuki, Tani, Hideki, Kobayashi, Ayako, Gohda, Jin, Kawaguchi, Yasushi, Park, Byoung Kwon, Kwon, Hyung-Joo, Inoue, Jun-ichiro, Alkattan, Abdallah
Publicado 2021

Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein

por Yamamoto, Mizuki, Gohda, Jin, Kobayashi, Ayako, Tomita, Keiko, Hirayama, Youko, Koshikawa, Naohiko, Seiki, Motoharu, Semba, Kentaro, Akiyama, Tetsu, Kawaguchi, Yasushi, Inoue, Jun-ichiro
Publicado 2022

Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection

por Duncan, Joseph K. Sampson, Xu, Danyang, Licursi, Maria, Joyce, Michael A., Saffran, Holly A., Liu, Kaiwen, Gohda, Jin, Tyrrell, D. Lorne, Kawaguchi, Yasushi, Hirasawa, Kensuke
Publicado 2023

Discovery of New Potent anti-MERS CoV Fusion Inhibitors

por Kandeel, Mahmoud, Yamamoto, Mizuki, Park, Byoung Kwon, Al-Taher, Abdulla, Watanabe, Aya, Gohda, Jin, Kawaguchi, Yasushi, Oh-hashi, Kentaro, Kwon, Hyung-Joo, Inoue, Jun-ichiro
Publicado 2021

HIV-1 replicates in human osteoclasts and enhances their differentiation in vitro

por Gohda, Jin, Ma, Yijing, Huang, Ying, Zhang, Yu, Gu, Lijun, Han, Yang, Li, Taisheng, Gao, Bin, Gao, George Fu, Inoue, Jun-ichiro, Iwamoto, Aikichi, Ishida, Takaomi
Publicado 2015

N-(4-Hydroxyphenyl) Retinamide Suppresses SARS-CoV-2 Spike Protein-Mediated Cell-Cell Fusion by a Dihydroceramide Δ4-Desaturase 1-Independent Mechanism

por Hayashi, Yasuhiro, Tsuchiya, Kiyoto, Yamamoto, Mizuki, Nemoto-Sasaki, Yoko, Tanigawa, Kazunari, Hama, Kotaro, Ueda, Yusuke, Tanikawa, Takashi, Gohda, Jin, Maeda, Kenji, Inoue, Jun-ichiro, Yamashita, Atsushi
Publicado 2021

In Silico and In Vitro Evaluation of Some Amidine Derivatives as Hit Compounds towards Development of Inhibitors against Coronavirus Diseases

por Hassan, Ahmed H. E., El-Sayed, Selwan M., Yamamoto, Mizuki, Gohda, Jin, Matsumoto, Takehisa, Shirouzu, Mikako, Inoue, Jun-ichiro, Kawaguchi, Yasushi, Mansour, Reem M. A., Anvari, Abtin, Farahat, Abdelbasset A.
Publicado 2023

A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis

por Liu, Changzhen, Zhao, Yunfeng, He, Wen, Wang, Wei, Chen, Yuan, Zhang, Shiqian, Ma, Yijing, Gohda, Jin, Ishida, Takaomi, Walter, Thomas S., Owens, Raymond J., Stuart, David I., Ren, Jingshan, Gao, Bin
Publicado 2015

The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner

por Yamamoto, Mizuki, Kiso, Maki, Sakai-Tagawa, Yuko, Iwatsuki-Horimoto, Kiyoko, Imai, Masaki, Takeda, Makoto, Kinoshita, Noriko, Ohmagari, Norio, Gohda, Jin, Semba, Kentaro, Matsuda, Zene, Kawaguchi, Yasushi, Kawaoka, Yoshihiro, Inoue, Jun-ichiro
Publicado 2020

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains

por Shibata, Yuri, Tokunaga, Fuminori, Goto, Eiji, Komatsu, Ginga, Gohda, Jin, Saeki, Yasushi, Tanaka, Keiji, Takahashi, Hirotaka, Sawasaki, Tatsuya, Inoue, Satoshi, Oshiumi, Hiroyuki, Seya, Tsukasa, Nakano, Hiroyasu, Tanaka, Yuetsu, Iwai, Kazuhiro, Inoue, Jun-ichiro
Publicado 2017

TRAF6 Establishes Innate Immune Responses by Activating NF-κB and IRF7 upon Sensing Cytosolic Viral RNA and DNA

por Konno, Hiroyasu, Yamamoto, Takuya, Yamazaki, Kohsuke, Gohda, Jin, Akiyama, Taishin, Semba, Kentaro, Goto, Hideo, Kato, Atsushi, Yujiri, Toshiaki, Imai, Takahiko, Kawaguchi, Yasushi, Su, Bing, Takeuchi, Osamu, Akira, Shizuo, Tsunetsugu-Yokota, Yasuko, Inoue, Jun-ichiro
Publicado 2009

Emergence of Lamivudine-Resistant HBV during Antiretroviral Therapy Including Lamivudine for Patients Coinfected with HIV and HBV in China

por Gu, Lijun, Han, Yang, Li, Yijia, Zhu, Ting, Song, Xiaojing, Huang, Ying, Yang, Feifei, Guan, Shuo, Xie, Jing, Gohda, Jin, Hosoya, Noriaki, Kawana-Tachikawa, Ai, Liu, Wenjun, Gao, George Fu, Iwamoto, Aikichi, Li, Taisheng, Ishida, Takaomi
Publicado 2015

Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling

por Varney, Melinda E., Niederkorn, Madeline, Konno, Hiroyasu, Matsumura, Takayuki, Gohda, Jin, Yoshida, Nobuaki, Akiyama, Taishin, Christie, Susanne, Fang, Jing, Miller, David, Jerez, Andres, Karsan, Aly, Maciejewski, Jaroslaw P., Meetei, Ruhikanta A., Inoue, Jun-ichiro, Starczynowski, Daniel T.
Publicado 2015

Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity

por Nakamura, Teruya, Hashikawa, Chie, Okabe, Kohtaro, Yokote, Yuya, Chirifu, Mami, Toma-Fukai, Sachiko, Nakamura, Narushi, Matsuo, Mihoko, Kamikariya, Miho, Okamoto, Yoshinari, Gohda, Jin, Akiyama, Taishin, Semba, Kentaro, Ikemizu, Shinji, Otsuka, Masami, Inoue, Jun-ichiro, Yamagata, Yuriko
Publicado 2020

Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19

por Ogura, Hideki, Gohda, Jin, Lu, Xiuyuan, Yamamoto, Mizuki, Takesue, Yoshio, Son, Aoi, Doi, Sadayuki, Matsushita, Kazuyuki, Isobe, Fumitaka, Fukuda, Yoshihiro, Huang, Tai-Ping, Ueno, Takamasa, Mambo, Naomi, Murakami, Hiromoto, Kawaguchi, Yasushi, Inoue, Jun-ichiro, Shirai, Kunihiro, Yamasaki, Sho, Hirata, Jun-Ichi, Ishido, Satoshi
Publicado 2022