Versatile transformations of hydrocarbons in anaerobic bacteria: substrate ranges and regio- and stereo-chemistry of activation reactions(†)

por Jarling, René, Kühner, Simon, Basílio Janke, Eline, Gruner, Andrea, Drozdowska, Marta, Golding, Bernard T., Rabus, Ralf, Wilkes, Heinz
Publicado 2015

Cyclizations and fragmentations in the alkylation of 6‐chloro‐5‐hydroxy‐4‐aminopyrimidines with aminoalkyl chlorides

por Picazo, Edwige M. H., Heptinstall, Amy B., Wilson, David M., Cano, Céline, Golding, Bernard T., Waring, Michael J.
Publicado 2021

Molecular Diversity via Tetrasubstituted Alkenes Containing a Barbiturate Motif: Synthesis and Biological Activity

por Al-Sheikh, Ahmed, Begum, Masuma, Zhang, Bian, Lewis, Richard A., Allenby, Nicholas E. E., Waddell, Paul G., Golding, Bernard T.
Publicado 2020

Metagenomic analysis and metabolite profiling of deep–sea sediments from the Gulf of Mexico following the Deepwater Horizon oil spill

por Kimes, Nikole E., Callaghan, Amy V., Aktas, Deniz F., Smith, Whitney L., Sunner, Jan, Golding, BernardT., Drozdowska, Marta, Hazen, Terry C., Suflita, Joseph M., Morris, Pamela J.
Publicado 2013

Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases

por Reuillon, Tristan, Alhasan, Sari F., Beale, Gary S., Bertoli, Annalisa, Brennan, Alfie, Cano, Celine, Reeves, Helen L., Newell, David R., Golding, Bernard T., Miller, Duncan C., Griffin, Roger J.
Publicado 2016

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase

por Mitcheson, Deborah F., Bottrill, Andrew R., Carr, Katherine, Coxon, Christopher R., Cano, Celine, Golding, Bernard T., Griffin, Roger J., Fry, Andrew M., Doerig, Christian, Bayliss, Richard, Tobin, Andrew B.
Publicado 2016

New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study

por Tommasino, Chiara, Gambardella, Lucrezia, Buoncervello, Maria, Griffin, Roger J., Golding, Bernard T., Alberton, Manuela, Macchia, Daniele, Spada, Massimo, Cerbelli, Bruna, d’Amati, Giulia, Malorni, Walter, Gabriele, Lucia, Giammarioli, Anna Maria
Publicado 2016

Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer

por Beale, Gary, Haagensen, Emma J, Thomas, Huw D, Wang, Lan-Zhen, Revill, Charlotte H, Payne, Sara L, Golding, Bernard T, Hardcastle, Ian R, Newell, David R, Griffin, Roger J, Cano, Celine
Publicado 2016

Build–Couple–Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity

por Uguen, Mélanie, Davison, Gemma, Sprenger, Lukas J., Hunter, James H., Martin, Mathew P., Turberville, Shannon, Watt, Jessica E., Golding, Bernard T., Noble, Martin E. M., Stewart, Hannah L., Waring, Michael J.
Publicado 2022

Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2–p53 and MDMX–p53 protein–protein interactions

por Blackburn, Tim J., Ahmed, Shafiq, Coxon, Christopher R., Liu, Junfeng, Lu, Xiaohong, Golding, Bernard T., Griffin, Roger J., Hutton, Claire, Newell, David R., Ojo, Stephen, Watson, Anna F., Zaytzev, Andrey, Zhao, Yan, Lunec, John, Hardcastle, Ian R.
Publicado 2013

Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer

por Coffey, Kelly, Blackburn, Timothy J., Cook, Susan, Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian R., Hewitt, Lorraine, Huberman, Kety, McNeill, Hesta V., Newell, David R., Roche, Celine, Ryan-Munden, Claudia A., Watson, Anna, Robson, Craig N.
Publicado 2012

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach

por Miller, Duncan C., Martin, Mathew P., Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine
Publicado 2018

2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase

por Matheson, Christopher J., Coxon, Christopher R., Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M., Hardcastle, Ian R., Harnor, Suzannah J., Mas-Droux, Corine, Newell, David R., Richards, Mark W., Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J., Golding, Bernard T., Cano, Céline
Publicado 2020

Structure-guided design of purine-based probes for selective Nek2 inhibition

por Coxon, Christopher R., Wong, Christopher, Bayliss, Richard, Boxall, Kathy, Carr, Katherine H., Fry, Andrew M., Hardcastle, Ian R., Matheson, Christopher J., Newell, David R., Sivaprakasam, Mangaleswaran, Thomas, Huw, Turner, David, Yeoh, Sharon, Wang, Lan Z., Griffin, Roger J., Golding, Bernard T., Cano, Céline
Publicado 2016

Identification and Characterization of an Irreversible Inhibitor of CDK2

por Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P., Staunton, David, Geitmann, Matthis, Danielson, U. Helena, Stanley, Will A., Wang, Lan Z., Reuillon, Tristan, Golding, Bernard T., Cano, Celine, Newell, David R., Noble, Martin E.M., Wedge, Stephen R., Endicott, Jane A., Griffin, Roger J.
Publicado 2015

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines

por Coxon, Christopher R., Anscombe, Elizabeth, Harnor, Suzannah J., Martin, Mathew P., Carbain, Benoit, Golding, Bernard T., Hardcastle, Ian R., Harlow, Lisa K., Korolchuk, Svitlana, Matheson, Christopher J., Newell, David R., Noble, Martin E. M., Sivaprakasam, Mangaleswaran, Tudhope, Susan J., Turner, David M., Wang, Lan Z., Wedge, Stephen R., Wong, Christopher, Griffin, Roger J., Endicott, Jane A., Cano, Céline
Publicado 2016

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

por Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian, Harnor, Suzannah J., Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P., Martin, Nick C., Myers, Stephanie, Newell, David R., Noble, Richard A., Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A., Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine
Publicado 2022