Stem cell models as an in vitro model for predictive toxicology

por Lynch, Stephen, Pridgeon, Chris S., Duckworth, Carrie A., Sharma, Parveen, Park, B. Kevin, Goldring, Chris E.P.
Publicado 2019

Suppression of the Nrf2-Dependent Antioxidant Response by Glucocorticoids and 11β-HSD1-Mediated Glucocorticoid Activation in Hepatic Cells

por Kratschmar, Denise V., Calabrese, Diego, Walsh, Jo, Lister, Adam, Birk, Julia, Appenzeller-Herzog, Christian, Moulin, Pierre, Goldring, Chris E., Odermatt, Alex
Publicado 2012

Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury

por Ali, Serat-E, Waddington, James C, Lister, Adam, Sison-Young, Rowena, Jones, Robert P, Rehman, Adeeb H, Goldring, Chris E P, Naisbitt, Dean J, Meng, Xiaoli
Publicado 2023

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

por Rowe, Cliff, Gerrard, Dave T, Jenkins, Roz, Berry, Andrew, Durkin, Kesta, Sundstrom, Lars, Goldring, Chris E, Park, B Kevin, Kitteringham, Neil R, Hanley, Karen Piper, Hanley, Neil A
Publicado 2013

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

por Lister, Adam, Nedjadi, Taoufik, Kitteringham, Neil R, Campbell, Fiona, Costello, Eithne, Lloyd, Bryony, Copple, Ian M, Williams, Samantha, Owen, Andrew, Neoptolemos, John P, Goldring, Chris E, Park, B Kevin
Publicado 2011

Donor‐Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte‐Like Ce...

por Heslop, James A., Kia, Richard, Pridgeon, Christopher S., Sison‐Young, Rowena L., Liloglou, Triantafillos, Elmasry, Mohamed, Fenwick, Stephen W., Mills, John S., Kitteringham, Neil R., Goldring, Chris E., Park, Bong K.
Publicado 2017

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

por Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.
Publicado 2016

Exosomal Transport of Hepatocyte‐Derived Drug‐Modified Proteins to the Immune System

por Ogese, Monday O., Jenkins, Rosalind E., Adair, Kareena, Tailor, Arun, Meng, Xiaoli, Faulkner, Lee, Enyindah, Bright O., Schofield, Amy, Diaz‐Nieto, Rafael, Ressel, Lorenzo, Eagle, Gina L., Kitteringham, Neil R., Goldring, Chris E., Park, B. Kevin, Naisbitt, Dean J., Betts, Catherine
Publicado 2019

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

por Baxter, Melissa, Withey, Sarah, Harrison, Sean, Segeritz, Charis-Patricia, Zhang, Fang, Atkinson-Dell, Rebecca, Rowe, Cliff, Gerrard, Dave T., Sison-Young, Rowena, Jenkins, Roz, Henry, Joanne, Berry, Andrew A., Mohamet, Lisa, Best, Marie, Fenwick, Stephen W., Malik, Hassan, Kitteringham, Neil R., Goldring, Chris E., Piper Hanley, Karen, Vallier, Ludovic, Hanley, Neil A.
Publicado 2015

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms

por Pridgeon, Chris S., Schlott, Constanze, Wong, Min Wei, Heringa, Minne B., Heckel, Tobias, Leedale, Joe, Launay, Laurence, Gryshkova, Vitalina, Przyborski, Stefan, Bearon, Rachel N., Wilkinson, Emma L., Ansari, Tahera, Greenman, John, Hendriks, Delilah F. G., Gibbs, Sue, Sidaway, James, Sison-Young, Rowena L., Walker, Paul, Cross, Mike J., Park, B. Kevin, Goldring, Chris E. P.
Publicado 2018

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

por Bell, Catherine C, Dankers, Anita C A, Lauschke, Volker M, Sison-Young, Rowena, Jenkins, Roz, Rowe, Cliff, Goldring, Chris E, Park, Kevin, Regan, Sophie L, Walker, Tracy, Schofield, Chris, Baze, Audrey, Foster, Alison J, Williams, Dominic P, van de Ven, Amy W M, Jacobs, Frank, van Houdt, Jos, Lähteenmäki, Tuula, Snoeys, Jan, Juhila, Satu, Richert, Lysiane, Ingelman-Sundberg, Magnus
Publicado 2018

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

por Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin
Publicado 2016

MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity

por Kia, Richard, Kelly, Lorna, Sison-Young, Rowena L. C., Zhang, Fang, Pridgeon, Chris S., Heslop, James A., Metcalfe, Pete, Kitteringham, Neil R., Baxter, Melissa, Harrison, Sean, Hanley, Neil A., Burke, Zoë D., Storm, Mike P., Welham, Melanie J., Tosh, David, Küppers-Munther, Barbara, Edsbagge, Josefina, Starkey Lewis, Philip J., Bonner, Frank, Harpur, Ernie, Sidaway, James, Bowes, Joanne, Fenwick, Stephen W., Malik, Hassan, Goldring, Chris E. P., Park, B. Kevin
Publicado 2015

Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies

por Scarfe, Lauren, Brillant, Nathalie, Kumar, J. Dinesh, Ali, Noura, Alrumayh, Ahmed, Amali, Mohammed, Barbellion, Stephane, Jones, Vendula, Niemeijer, Marije, Potdevin, Sophie, Roussignol, Gautier, Vaganov, Anatoly, Barbaric, Ivana, Barrow, Michael, Burton, Neal C., Connell, John, Dazzi, Francesco, Edsbagge, Josefina, French, Neil S., Holder, Julie, Hutchinson, Claire, Jones, David R., Kalber, Tammy, Lovatt, Cerys, Lythgoe, Mark F., Patel, Sara, Patrick, P. Stephen, Piner, Jacqueline, Reinhardt, Jens, Ricci, Emanuelle, Sidaway, James, Stacey, Glyn N., Starkey Lewis, Philip J., Sullivan, Gareth, Taylor, Arthur, Wilm, Bettina, Poptani, Harish, Murray, Patricia, Goldring, Chris E. P., Park, B. Kevin
Publicado 2017

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of...

por Godoy, Patricio, Hewitt, Nicola J., Albrecht, Ute, Andersen, Melvin E., Ansari, Nariman, Bhattacharya, Sudin, Bode, Johannes Georg, Bolleyn, Jennifer, Borner, Christoph, Böttger, Jan, Braeuning, Albert, Budinsky, Robert A., Burkhardt, Britta, Cameron, Neil R., Camussi, Giovanni, Cho, Chong-Su, Choi, Yun-Jaie, Craig Rowlands, J., Dahmen, Uta, Damm, Georg, Dirsch, Olaf, Donato, María Teresa, Dong, Jian, Dooley, Steven, Drasdo, Dirk, Eakins, Rowena, Ferreira, Karine Sá, Fonsato, Valentina, Fraczek, Joanna, Gebhardt, Rolf, Gibson, Andrew, Glanemann, Matthias, Goldring, Chris E. P., Gómez-Lechón, María José, Groothuis, Geny M. M., Gustavsson, Lena, Guyot, Christelle, Hallifax, David, Hammad, Seddik, Hayward, Adam, Häussinger, Dieter, Hellerbrand, Claus, Hewitt, Philip, Hoehme, Stefan, Holzhütter, Hermann-Georg, Houston, J. Brian, Hrach, Jens, Ito, Kiyomi, Jaeschke, Hartmut, Keitel, Verena, Kelm, Jens M., Kevin Park, B., Kordes, Claus, Kullak-Ublick, Gerd A., LeCluyse, Edward L., Lu, Peng, Luebke-Wheeler, Jennifer, Lutz, Anna, Maltman, Daniel J., Matz-Soja, Madlen, McMullen, Patrick, Merfort, Irmgard, Messner, Simon, Meyer, Christoph, Mwinyi, Jessica, Naisbitt, Dean J., Nussler, Andreas K., Olinga, Peter, Pampaloni, Francesco, Pi, Jingbo, Pluta, Linda, Przyborski, Stefan A., Ramachandran, Anup, Rogiers, Vera, Rowe, Cliff, Schelcher, Celine, Schmich, Kathrin, Schwarz, Michael, Singh, Bijay, Stelzer, Ernst H. K., Stieger, Bruno, Stöber, Regina, Sugiyama, Yuichi, Tetta, Ciro, Thasler, Wolfgang E., Vanhaecke, Tamara, Vinken, Mathieu, Weiss, Thomas S., Widera, Agata, Woods, Courtney G., Xu, Jinghai James, Yarborough, Kathy M., Hengstler, Jan G.
Publicado 2013