Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver Injury

por Cox, Christopher R., Lynch, Stephen, Goldring, Christopher, Sharma, Parveen
Publicado 2020

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3

por Bone, Heather K., Nelson, Adam S., Goldring, Christopher E., Tosh, David, Welham, Melanie J.
Publicado 2011

Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification

por Howell, Lawrence, Jenkins, Rosalind E., Lynch, Stephen, Duckworth, Carrie, Kevin Park, B., Goldring, Christopher
Publicado 2021

The application of cytokeratin-18 as a biomarker for drug-induced liver injury

por Korver, Samantha, Bowen, Joanne, Pearson, Kara, Gonzalez, Raymond J., French, Neil, Park, Kevin, Jenkins, Rosalind, Goldring, Christopher
Publicado 2021

Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB()

por Chia, Alvin J.L., Goldring, Christopher E., Kitteringham, Neil R., Wong, Shi Quan, Morgan, Paul, Park, B. Kevin
Publicado 2010

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

por Forootan, Shiva S., Mutter, Fiona E., Kipar, Anja, Iwawaki, Takao, Francis, Ben, Goldring, Christopher E., Park, B. Kevin, Copple, Ian M.
Publicado 2017

Critical considerations for targeting colorectal liver metastases with nanotechnology

por Arshad, Usman, Sutton, Paul A., Ashford, Marianne B., Treacher, Kevin E., Liptrott, Neill J., Rannard, Steve P., Goldring, Christopher E., Owen, Andrew
Publicado 2019

VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells

por Mondru, Anil Kumar, Aljasir, Mohammad A., Alrumayh, Ahmed, Nithianandarajah, Gopika N., Ahmed, Katie, Muller, Jurgen, Goldring, Christopher E. P., Wilm, Bettina, Cross, Michael J.
Publicado 2023

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

por Copple, Ian M., Lister, Adam, Obeng, Akua D., Kitteringham, Neil R., Jenkins, Rosalind E., Layfield, Robert, Foster, Brian J., Goldring, Christopher E., Park, B. Kevin
Publicado 2010

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

por Copple, Ian M., Shelton, Luke M., Walsh, Joanne, Kratschmar, Denise V., Lister, Adam, Odermatt, Alex, Goldring, Christopher E., Dinkova-Kostova, Albena T., Honda, Tadashi, Park, B. Kevin
Publicado 2014

Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research

por Evans, Jonathan P, Winiarski, Boleslaw K, Sutton, Paul A, Ressel, Lorenzo, Duckworth, Carrie A, Pritchard, D Mark, Palmer, Daniel H, Goldring, Christopher E, Kitteringham, Neil R
Publicado 2019

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

por Walsh, Joanne, Jenkins, Rosalind E., Wong, Michael, Olayanju, Adedamola, Powell, Helen, Copple, Ian, O’Neill, Paul M., Goldring, Christopher E.P., Kitteringham, Neil R., Park, B. Kevin
Publicado 2014

Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signali...

por Yeang, Han Xian Aw, Hamdam, Junnat M., Al-Huseini, Laith M. A., Sethu, Swaminathan, Djouhri, Laiche, Walsh, Joanne, Kitteringham, Neil, Park, B. Kevin, Goldring, Christopher E., Sathish, Jean G.
Publicado 2012

Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activ...

por Al-Huseini, Laith M. A., Aw Yeang, Han Xian, Sethu, Swaminathan, Alhumeed, Naif, Hamdam, Junnat M., Tingle, Yulia, Djouhri, Laiche, Kitteringham, Neil, Park, B. Kevin, Goldring, Christopher E., Sathish, Jean G.
Publicado 2013

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

por Kitteringham, Neil R., Abdullah, Azman, Walsh, Joanne, Randle, Laura, Jenkins, Rosalind E., Sison, Rowena, Goldring, Christopher E.P., Powell, Helen, Sanderson, Christopher, Williams, Samantha, Higgins, Larry, Yamamoto, Masayuki, Hayes, John, Park, B. Kevin
Publicado 2010

Safety perspectives on presently considered drugs for the treatment of COVID‐19

por Penman, Sophie L., Kiy, Robyn T., Jensen, Rebecca L., Beoku‐Betts, Christopher, Alfirevic, Ana, Back, David, Khoo, Saye H., Owen, Andrew, Pirmohamed, Munir, Park, B. Kevin, Meng, Xiaoli, Goldring, Christopher E., Chadwick, Amy E.
Publicado 2020

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

por Antoine, Daniel J, Dear, James W, Lewis, Philip Starkey, Platt, Vivien, Coyle, Judy, Masson, Moyra, Thanacoody, Ruben H, Gray, Alasdair J, Webb, David J, Moggs, Jonathan G, Bateman, D Nicholas, Goldring, Christopher E, Park, B Kevin
Publicado 2013

Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System

por Ali, Serat-E, Meng, Xiaoli, Kafu, Laila, Hammond, Sean, Zhao, Qing, Ogese, Monday, Sison-Young, Rowena, Jones, Robert, Chan, Benjamin, Livoti, Lucia, Sun, Yonghu, Sun, Lele, Liu, Hong, Topping, Anthony, Goldring, Christopher, Zhang, Furen, Naisbitt, Dean John
Publicado 2023

NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis

por Lister, Adam, Bourgeois, Soline, Imenez Silva, Pedro H., Rubio-Aliaga, Isabel, Marbet, Philippe, Walsh, Joanne, Shelton, Luke M., Keller, Bettina, Verrey, Francois, Devuyst, Olivier, Giesbertz, Pieter, Daniel, Hannelore, Goldring, Christopher E., Copple, Ian M., Wagner, Carsten A., Odermatt, Alex
Publicado 2018

UHRF1 regulation of the Keap1–Nrf2 pathway in pancreatic cancer contributes to oncogenesis

por Abu‐Alainin, Wafa, Gana, Thompson, Liloglou, Triantafillos, Olayanju, Adedamola, Barrera, Lawrence N, Ferguson, Robert, Campbell, Fiona, Andrews, Timothy, Goldring, Christopher, Kitteringham, Neil, Park, Brian K, Nedjadi, Taoufik, Schmid, Michael C, Slupsky, Joseph R, Greenhalf, William, Neoptolemos, John P, Costello, Eithne
Publicado 2015