A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3

por Bone, Heather K., Nelson, Adam S., Goldring, Christopher E., Tosh, David, Welham, Melanie J.
Publicado 2011

Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB()

por Chia, Alvin J.L., Goldring, Christopher E., Kitteringham, Neil R., Wong, Shi Quan, Morgan, Paul, Park, B. Kevin
Publicado 2010

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

por Forootan, Shiva S., Mutter, Fiona E., Kipar, Anja, Iwawaki, Takao, Francis, Ben, Goldring, Christopher E., Park, B. Kevin, Copple, Ian M.
Publicado 2017

Critical considerations for targeting colorectal liver metastases with nanotechnology

por Arshad, Usman, Sutton, Paul A., Ashford, Marianne B., Treacher, Kevin E., Liptrott, Neill J., Rannard, Steve P., Goldring, Christopher E., Owen, Andrew
Publicado 2019

VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells

por Mondru, Anil Kumar, Aljasir, Mohammad A., Alrumayh, Ahmed, Nithianandarajah, Gopika N., Ahmed, Katie, Muller, Jurgen, Goldring, Christopher E. P., Wilm, Bettina, Cross, Michael J.
Publicado 2023

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

por Copple, Ian M., Lister, Adam, Obeng, Akua D., Kitteringham, Neil R., Jenkins, Rosalind E., Layfield, Robert, Foster, Brian J., Goldring, Christopher E., Park, B. Kevin
Publicado 2010

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

por Copple, Ian M., Shelton, Luke M., Walsh, Joanne, Kratschmar, Denise V., Lister, Adam, Odermatt, Alex, Goldring, Christopher E., Dinkova-Kostova, Albena T., Honda, Tadashi, Park, B. Kevin
Publicado 2014

Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research

por Evans, Jonathan P, Winiarski, Boleslaw K, Sutton, Paul A, Ressel, Lorenzo, Duckworth, Carrie A, Pritchard, D Mark, Palmer, Daniel H, Goldring, Christopher E, Kitteringham, Neil R
Publicado 2019

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

por Walsh, Joanne, Jenkins, Rosalind E., Wong, Michael, Olayanju, Adedamola, Powell, Helen, Copple, Ian, O’Neill, Paul M., Goldring, Christopher E.P., Kitteringham, Neil R., Park, B. Kevin
Publicado 2014

Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signali...

por Yeang, Han Xian Aw, Hamdam, Junnat M., Al-Huseini, Laith M. A., Sethu, Swaminathan, Djouhri, Laiche, Walsh, Joanne, Kitteringham, Neil, Park, B. Kevin, Goldring, Christopher E., Sathish, Jean G.
Publicado 2012

Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activ...

por Al-Huseini, Laith M. A., Aw Yeang, Han Xian, Sethu, Swaminathan, Alhumeed, Naif, Hamdam, Junnat M., Tingle, Yulia, Djouhri, Laiche, Kitteringham, Neil, Park, B. Kevin, Goldring, Christopher E., Sathish, Jean G.
Publicado 2013

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

por Kitteringham, Neil R., Abdullah, Azman, Walsh, Joanne, Randle, Laura, Jenkins, Rosalind E., Sison, Rowena, Goldring, Christopher E.P., Powell, Helen, Sanderson, Christopher, Williams, Samantha, Higgins, Larry, Yamamoto, Masayuki, Hayes, John, Park, B. Kevin
Publicado 2010

Safety perspectives on presently considered drugs for the treatment of COVID‐19

por Penman, Sophie L., Kiy, Robyn T., Jensen, Rebecca L., Beoku‐Betts, Christopher, Alfirevic, Ana, Back, David, Khoo, Saye H., Owen, Andrew, Pirmohamed, Munir, Park, B. Kevin, Meng, Xiaoli, Goldring, Christopher E., Chadwick, Amy E.
Publicado 2020

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

por Antoine, Daniel J, Dear, James W, Lewis, Philip Starkey, Platt, Vivien, Coyle, Judy, Masson, Moyra, Thanacoody, Ruben H, Gray, Alasdair J, Webb, David J, Moggs, Jonathan G, Bateman, D Nicholas, Goldring, Christopher E, Park, B Kevin
Publicado 2013

NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis

por Lister, Adam, Bourgeois, Soline, Imenez Silva, Pedro H., Rubio-Aliaga, Isabel, Marbet, Philippe, Walsh, Joanne, Shelton, Luke M., Keller, Bettina, Verrey, Francois, Devuyst, Olivier, Giesbertz, Pieter, Daniel, Hannelore, Goldring, Christopher E., Copple, Ian M., Wagner, Carsten A., Odermatt, Alex
Publicado 2018

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and De...

por Sison-Young, Rowena L. C., Mitsa, Dimitra, Jenkins, Rosalind E., Mottram, David, Alexandre, Eliane, Richert, Lysiane, Aerts, Hélène, Weaver, Richard J., Jones, Robert P., Johann, Esther, Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Christopher E. P., Kitteringham, Neil R., Park, B. Kevin
Publicado 2015

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney

por Shelton, Luke M., Lister, Adam, Walsh, Joanne, Jenkins, Rosalind E., Wong, Michael H. L., Rowe, Cliff, Ricci, Emanuele, Ressel, Lorenzo, Fang, Yongxiang, Demougin, Philippe, Vukojevic, Vanja, O’Neill, Paul M., Goldring, Christopher E., Kitteringham, Neil R., Park, B. Kevin, Odermatt, Alex, Copple, Ian M.
Publicado 2015

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

por Evans, Jonathan P., Winiarski, Boleslaw K., Sutton, Paul A., Jones, Robert P., Ressel, Lorenzo, Duckworth, Carrie A., Pritchard, D. Mark, Lin, Zhi-Xiu, Vicky, Fretwell L., Tweedle, Elizabeth M., Costello, Eithne, Goldring, Christopher E., Copple, Ian M., Park, B. Kevin, Palmer, Daniel H., Kitteringham, Neil R.
Publicado 2018

Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

por Evans, Jonathan P., Winiarski, Boleslaw K., Sutton, Paul A., Jones, Robert P., Ressel, Lorenzo, Duckworth, Carrie A., Pritchard, D. Mark, Lin, Zhi-Xiu, Fretwell, Vicky L., Tweedle, Elizabeth M., Costello, Eithne, Goldring, Christopher E., Copple, Ian M., Park, B. Kevin, Palmer, Daniel H., Kitteringham, Neil R.
Publicado 2019

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

por Copple, Ian M., den Hollander, Wouter, Callegaro, Giulia, Mutter, Fiona E., Maggs, James L., Schofield, Amy L., Rainbow, Lucille, Fang, Yongxiang, Sutherland, Jeffrey J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Fenwick, Stephen W., Goldring, Christopher E., van de Water, Bob, Stevens, James L., Park, B. Kevin
Publicado 2018