New Disulphide Bond in Cystatin-Based Protein Scaffold Prevents Domain-Swap-Mediated Oligomerization and Stabilizes the Functionally Active Form

por Zalar, Matja, Golovanov, Alexander P.
Publicado 2019

Temporal and spatial characterisation of protein liquid-liquid phase separation using NMR spectroscopy

por Bramham, Jack E., Golovanov, Alexander P.
Publicado 2022

Sample illumination device facilitates in situ light-coupled NMR spectroscopy without fibre optics

por Bramham, Jack E., Golovanov, Alexander P.
Publicado 2022

Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution

por Vo, Uybach, Vajpai, Navratna, Embrey, Kevin J., Golovanov, Alexander P.
Publicado 2016

Comprehensive Assessment of Protein and Excipient Stability in Biopharmaceutical Formulations Using (1)H NMR Spectroscopy

por Bramham, Jack E., Podmore, Adrian, Davies, Stephanie A., Golovanov, Alexander P.
Publicado 2020

Stability of a high-concentration monoclonal antibody solution produced by liquid–liquid phase separation

por Bramham, Jack E., Davies, Stephanie A., Podmore, Adrian, Golovanov, Alexander P.
Publicado 2021

Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF

por Tunnicliffe, Richard B., Hautbergue, Guillaume M., Wilson, Stuart A., Kalra, Priti, Golovanov, Alexander P.
Publicado 2014

Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF

por Tunnicliffe, Richard B., Tian, Xiaochen, Storer, Joanna, Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Publicado 2018

Characterizing monoclonal antibody formulations in arginine glutamate solutions using (1)H NMR spectroscopy

por Kheddo, Priscilla, Cliff, Matthew J., Uddin, Shahid, van der Walle, Christopher F., Golovanov, Alexander P.
Publicado 2016

Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition

por Tunnicliffe, Richard B, Levy, Colin, Ruiz Nivia, Hilda D, Sandri-Goldin, Rozanne M, Golovanov, Alexander P
Publicado 2019

The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer

por Tunnicliffe, Richard B., Schacht, Mitchell, Levy, Colin, Jowitt, Thomas A., Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Publicado 2015

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence

por Vo, Uybach, Vajpai, Navratna, Flavell, Liz, Bobby, Romel, Breeze, Alexander L., Embrey, Kevin J., Golovanov, Alexander P.
Publicado 2016

The effects of arginine glutamate, a promising excipient for protein formulation, on cell viability: Comparisons with NaCl

por Kheddo, Priscilla, Golovanov, Alexander P., Mellody, Kieran T., Uddin, Shahid, van der Walle, Christopher F., Dearman, Rebecca J.
Publicado 2016

The ICP27 Homology Domain of the Human Cytomegalovirus Protein UL69 Adopts a Dimer-of-Dimers Structure

por Tunnicliffe, Richard B., Collins, Richard F., Ruiz Nivia, Hilda D., Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Publicado 2018

Studies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold

por Zalar, Matja, Indrakumar, Sowmya, Levy, Colin W., Tunnicliffe, Richard B., Peters, Günther H. J., Golovanov, Alexander P.
Publicado 2019

Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57

por Tunnicliffe, Richard B., Hautbergue, Guillaume M., Kalra, Priti, Jackson, Brian R., Whitehouse, Adrian, Wilson, Stuart A., Golovanov, Alexander P.
Publicado 2011

The effect of arginine glutamate on the stability of monoclonal antibodies in solution

por Kheddo, Priscilla, Tracka, Malgorzata, Armer, Jonathan, Dearman, Rebecca J., Uddin, Shahid, van der Walle, Christopher F., Golovanov, Alexander P.
Publicado 2014

(19)F Dark-State Exchange Saturation Transfer NMR Reveals Reversible Formation of Protein-Specific Large Clusters in High-Concentration Protein Mixtures

por Edwards, John M., Bramham, Jack E., Podmore, Adrian, Bishop, Steven M., van der Walle, Christopher F., Golovanov, Alexander P.
Publicado 2019

Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27

por Tunnicliffe, Richard B., Hu, William K., Wu, Michele Y., Levy, Colin, Mould, A. Paul, McKenzie, Edward A., Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Publicado 2019

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

por Tunnicliffe, Richard B., Lockhart-Cairns, Michael P., Levy, Colin, Mould, A. Paul, Jowitt, Thomas A., Sito, Hilary, Baldock, Clair, Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Publicado 2017