Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus

por Good, Steven S., Moussa, Adel, Zhou, Xiao-Jian, Pietropaolo, Keith, Sommadossi, Jean-Pierre
Publicado 2020

1265. AT-527, an Oral Purine Nucleotide Prodrug Exhibiting Potent In Vitro Antiviral Activity Against Human Coronaviruses, Including SARS-CoV-2

por Good, Steven S, Moussa, Adel, Zhou, Xiao-Jian, Pietropaolo, Keith, Sommadossi, Jean-Pierre
Publicado 2020

169. AT-752, an Oral Guanosine Nucleotide Prodrug, Exhibits Potent in Vitro Activity Against Flaviviruses and Prevents Disease Progression in a Dengue Mouse Model

por Good, Steven S, Moussa, Adel, Zhou, Xiao-Jian, Sommadossi, Jean-Pierre, Pietropaolo, Keith
Publicado 2020

Discovery of a Series of Potent and Selective Nucleotide Prodrug Inhibitors of Respiratory Syncytial Virus (RSV) Replication

por Good, Steven, Moussa, Adel, Meillon, Jean-Cristophe, Zhou, Xiao-Jian, Pietropaolo, Keith, Sommadossi, Jean-Pierre
Publicado 2017

AT-752, a double prodrug of a guanosine nucleotide analog, inhibits yellow fever virus in a hamster model

por Lin, Kai, Good, Steven S., Julander, Justin G., Weight, Abbie E., Moussa, Adel, Sommadossi, Jean-Pierre
Publicado 2022

Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses

por Good, Steven S., Shannon, Ashleigh, Lin, Kai, Moussa, Adel, Julander, Justin G., La Colla, Paolo, Collu, Gabriella, Canard, Bruno, Sommadossi, Jean-Pierre
Publicado 2021

AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19

por Good, Steven S., Westover, Jonna, Jung, Kie Hoon, Zhou, Xiao-Jian, Moussa, Adel, La Colla, Paolo, Collu, Gabriella, Canard, Bruno, Sommadossi, Jean-Pierre
Publicado 2021

Safety, Pharmacokinetics, and Antiviral Activity of AT-527, a Novel Purine Nucleotide Prodrug, in Hepatitis C Virus-Infected Subjects with or without Cirrhosis

por Berliba, Elina, Bogus, Maxim, Vanhoutte, Frédéric, Berghmans, Pieter-Jan, Good, Steven S., Moussa, Adel, Pietropaolo, Keith, Murphy, Robert L., Zhou, Xiao-Jian, Sommadossi, Jean-Pierre
Publicado 2019

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

por Shannon, Ashleigh, Fattorini, Véronique, Sama, Bhawna, Selisko, Barbara, Feracci, Mikael, Falcou, Camille, Gauffre, Pierre, El Kazzi, Priscila, Delpal, Adrien, Decroly, Etienne, Alvarez, Karine, Eydoux, Cécilia, Guillemot, Jean-Claude, Moussa, Adel, Good, Steven S., La Colla, Paolo, Lin, Kai, Sommadossi, Jean-Pierre, Zhu, Yingxiao, Yan, Xiaodong, Shi, Hui, Ferron, François, Canard, Bruno
Publicado 2022