VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer

por Lee, Ye S., Klomp, Jennifer E., Stalnecker, Clint A., Goodwin, Craig M., Gao, Yanzhe, Droby, Gaith N., Vaziri, Cyrus, Bryant, Kirsten L., Der, Channing J., Cox, Adrienne D.
Publicado 2023

Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen

por Barkovskaya, Anna, Goodwin, Craig M., Seip, Kotryna, Hilmarsdottir, Bylgja, Pettersen, Solveig, Stalnecker, Clint, Engebraaten, Olav, Briem, Eirikur, Der, Channing J., Moestue, Siver A., Gudjonsson, Thorarinn, Mælandsmo, Gunhild M., Prasmickaite, Lina
Publicado 2021

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

por Ozkan-Dagliyan, Irem, Diehl, J. Nathaniel, George, Samuel D., Schaefer, Antje, Papke, Bjoern, Klotz-Noack, Kathleen, Waters, Andrew M., Goodwin, Craig M., Gautam, Prson, Pierobon, Mariaelena, Peng, Sen, Gilbert, Thomas S.K., Lin, Kevin H., Dagliyan, Onur, Wennerberg, Krister, Petricoin, Emanuel F., Tran, Nhan L., Bhagwat, Shripad V., Tiu, Ramon V., Peng, Sheng-Bin, Herring, Laura E., Graves, Lee M., Sers, Christine, Wood, Kris C., Cox, Adrienne D., Der, Channing J.
Publicado 2020

CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

por Klomp, Jennifer E., Lee, Ye S., Goodwin, Craig M., Papke, Björn, Klomp, Jeff A., Waters, Andrew M., Stalnecker, Clint A., DeLiberty, Jonathan M., Drizyte-Miller, Kristina, Yang, Runying, Diehl, J. Nathaniel, Yin, Hongwei H., Pierobon, Mariaelena, Baldelli, Elisa, Ryan, Meagan B., Li, Siqi, Peterson, Jackson, Smith, Amber R., Neal, James T., McCormick, Aaron K., Kuo, Calvin J., Counter, Christopher M., Petricoin, Emanuel F., Cox, Adrienne D., Bryant, Kirsten L., Der, Channing J.
Publicado 2021

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

por Waters, Andrew M., Khatib, Tala O., Papke, Bjoern, Goodwin, Craig M., Hobbs, G. Aaron, Diehl, J. Nathaniel, Yang, Runying, Edwards, A. Cole, Walsh, Katherine H., Sulahian, Rita, McFarland, James M., Kapner, Kevin S., Gilbert, Thomas S.K., Stalnecker, Clint A., Javaid, Sehrish, Barkovskaya, Anna, Grover, Kajal R., Hibshman, Priya S., Blake, Devon R., Schaefer, Antje, Nowak, Katherine M., Klomp, Jennifer E., Hayes, Tikvah K., Kassner, Michelle, Tang, Nanyun, Tanaseichuk, Olga, Chen, Kaisheng, Zhou, Yingyao, Kalkat, Manpreet, Herring, Laura E., Graves, Lee M., Penn, Linda Z., Yin, Hongwei H., Aguirre, Andrew J., Hahn, William C., Cox, Adrienne D., Der, Channing J.
Publicado 2021