Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis

por Yee, Michelle, Gopal, Pooja, Dick, Thomas
Publicado 2017

G9a mediates Sharp-1–dependent inhibition of skeletal muscle differentiation

por Ling, Belinda Mei Tze, Gopinadhan, Suma, Kok, Wai Kay, Shankar, Shilpa Rani, Gopal, Pooja, Bharathy, Narendra, Wang, Yaju, Taneja, Reshma
Publicado 2012

In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1

por Gopal, Pooja, Tasneen, Rokeya, Yee, Michelle, Lanoix, Jean-Philippe, Sarathy, Jansy, Rasic, George, Li, Liping, Dartois, Véronique, Nuermberger, Eric, Dick, Thomas
Publicado 2017

Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology

por Garrigou, Michael, Sauvagnat, Bérengère, Duggal, Ruchia, Boo, Nicole, Gopal, Pooja, Johnston, Jennifer M., Partridge, Anthony, Sawyer, Tomi, Biswas, Kaustav, Boyer, Nicolas
Publicado 2022

The Mycobacterial Membrane: A Novel Target Space for Anti-tubercular Drugs

por Chen, Huan, Nyantakyi, Samuel A., Li, Ming, Gopal, Pooja, Aziz, Dinah B., Yang, Tianming, Moreira, Wilfried, Gengenbacher, Martin, Dick, Thomas, Go, Mei L.
Publicado 2018

Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States

por Lim, Shuhui, Khoo, Regina, Juang, Yu-Chi, Gopal, Pooja, Zhang, Huibin, Yeo, Constance, Peh, Khong Ming, Teo, Jinkai, Ng, Simon, Henry, Brian, Partridge, Anthony W.
Publicado 2020

Pyrazinamide triggers degradation of its target aspartate decarboxylase

por Gopal, Pooja, Sarathy, Jickky Palmae, Yee, Michelle, Ragunathan, Priya, Shin, Joon, Bhushan, Shashi, Zhu, Junhao, Akopian, Tatos, Kandror, Olga, Lim, Teck Kwang, Gengenbacher, Martin, Lin, Qingsong, Rubin, Eric J., Grüber, Gerhard, Dick, Thomas
Publicado 2020

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N(1))-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism

por Zhong, Wenhe, Pasunooti, Kalyan Kumar, Balamkundu, Seetharamsing, Wong, Yee Hwa, Nah, Qianhui, Gadi, Vinod, Gnanakalai, Shanmugavel, Chionh, Yok Hian, McBee, Megan E., Gopal, Pooja, Lim, Siau Hoi, Olivier, Nelson, Buurman, Ed T., Dick, Thomas, Liu, Chuan Fa, Lescar, Julien, Dedon, Peter C.
Publicado 2019

STUB1 is an intracellular checkpoint for interferon gamma sensing

por Ng, Simon, Lim, Shuhui, Sim, Adrian Chong Nyi, Mangadu, Ruban, Lau, Ally, Zhang, Chunsheng, Martinez, Sarah Bollinger, Chandramohan, Arun, Lim, U-Ming, Ho, Samantha Shu Wen, Chang, Shih Chieh, Gopal, Pooja, Hong, Lewis Z., Schwaid, Adam, Fernandis, Aaron Zefrin, Loboda, Andrey, Li, Cai, Phan, Uyen, Henry, Brian, Partridge, Anthony W.
Publicado 2022

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

por Lim, Shuhui, Boyer, Nicolas, Boo, Nicole, Huang, Chunhui, Venkatachalam, Gireedhar, Angela Juang, Yu-Chi, Garrigou, Michael, Kaan, Hung Yi Kristal, Duggal, Ruchia, Peh, Khong Ming, Sadruddin, Ahmad, Gopal, Pooja, Yuen, Tsz Ying, Ng, Simon, Kannan, Srinivasaraghavan, Brown, Christopher J., Verma, Chandra S., Orth, Peter, Peier, Andrea, Ge, Lan, Yu, Xiang, Bhatt, Bhavana, Chen, Feifei, Wang, Erjia, Li, Nianyu Jason, Gonzales, Raymond J., Stoeck, Alexander, Henry, Brian, Sawyer, Tomi K., Lane, David P., Johannes, Charles W., Biswas, Kaustav, Partridge, Anthony W.
Publicado 2021