Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation

por Pessentheiner, Ariane R., Ducasa, G. Michelle, Gordts, Philip L. S. M.
Publicado 2020

Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions

por Weiss, Ryan J., Gordts, Philip L. S. M., Le, Dzung, Xu, Ding, Esko, Jeffrey D., Tor, Yitzhak
Publicado 2015

Impaired LDL Receptor-Related Protein 1 Translocation Correlates with Improved Dyslipidemia and Atherosclerosis in apoE-Deficient Mice

por Gordts, Philip L.S.M., Bartelt, Alexander, Nilsson, Stefan K., Annaert, Wim, Christoffersen, Christina, Nielsen, Lars Bo, Heeren, Joerg, Roebroek, Anton J.M.
Publicado 2012

The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins

por Fischer, Alexander W., Albers, Kirstin, Krott, Lucia M., Hoffzimmer, Britta, Heine, Markus, Schmale, Hartwig, Scheja, Ludger, Gordts, Philip L.S.M., Heeren, Joerg
Publicado 2018

Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I

por Khalid, Omar, Vera, Moin U., Gordts, Philip L., Ellinwood, N. Matthew, Schwartz, Philip H., Dickson, Patricia I., Esko, Jeffrey D., Wang, Raymond Y.
Publicado 2016

Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice

por Poli, Maura, Anower-E-Khuda, Ferdous, Asperti, Michela, Ruzzenenti, Paola, Gryzik, Magdalena, Denardo, Andrea, Gordts, Philip L. S. M., Arosio, Paolo, Esko, Jeffrey D.
Publicado 2019

LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease

por Van Gool, Bart, Storck, Steffen E., Reekmans, Sara M., Lechat, Benoit, Gordts, Philip L. S. M., Pradier, Laurent, Pietrzik, Claus U., Roebroek, Anton J. M.
Publicado 2019

Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism

por Trieger, Greg W., Pessentheiner, Ariane R., Purcell, Sean C., Green, Courtney R., DeForest, Natalie, Willert, Karl, Majithia, Amit R., Metallo, Christian M., Godula, Kamil, Gordts, Philip L.S.M.
Publicado 2023

Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering

por Ramms, Bastian, Patel, Sohan, Sun, Xiaoli, Pessentheiner, Ariane R., Ducasa, G. Michelle, Mullick, Adam E., Lee, Richard G., Crooke, Rosanne M., Tsimikas, Sotirios, Witztum, Joseph L., Gordts, Philip L.S.M.
Publicado 2022

Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development

por Yang, Xiaojing, Weber, André A., Mennillo, Elvira, Secrest, Patrick, Chang, Max, Wong, Samantha, Le, Sabrina, Liu, Junlai, Benner, Christopher W., Karin, Michael, Gordts, Philip L.S.M., Tukey, Robert H., Chen, Shujuan
Publicado 2023

microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production

por Dong, Jianjie, He, Ming, Li, Jie, Pessentheiner, Ariane, Wang, Chen, Zhang, Jin, Sun, Yameng, Wang, Wei-Ting, Zhang, Yuqing, Liu, Junhui, Wang, Shen-Chih, Huang, Po-Hsun, Gordts, Philip L.S.M., Yuan, Zu-Yi, Tsimikas, Sotirios, Shyy, John Y.J.
Publicado 2020

ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

por Ramms, Bastian, Patel, Sohan, Nora, Chelsea, Pessentheiner, Ariane R., Chang, Max W., Green, Courtney R., Golden, Gregory J., Secrest, Patrick, Krauss, Ronald M., Metallo, Christian M., Benner, Christopher, Alexander, Veronica J., Witztum, Joseph L., Tsimikas, Sotirios, Esko, Jeffrey D., Gordts, Philip L. S. M.
Publicado 2019

Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

por Weiss, Ryan J., Spahn, Philipp N., Chiang, Austin W.T., Liu, Qing, Li, Jing, Hamill, Kristina M., Rother, Sandra, Clausen, Thomas M., Hoeksema, Marten A., Timm, Bryce M., Godula, Kamil, Glass, Christopher K., Tor, Yitzhak, Gordts, Philip L.S.M., Lewis, Nathan E., Esko, Jeffrey D.
Publicado 2021

Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins

por DeForest, Natalie, Kavitha, Babu, Hu, Siqi, Isaac, Roi, Krohn, Lynne, Wang, Minxian, Du, Xiaomi, De Arruda Saldanha, Camila, Gylys, Jenny, Merli, Edoardo, Abagyan, Ruben, Najmi, Laeya, Mohan, Viswanathan, Flannick, Jason, Peloso, Gina M., Gordts, Philip L.S.M., Heinz, Sven, Deaton, Aimee M., Khera, Amit V., Olefsky, Jerrold, Radha, Venkatesan, Majithia, Amit R.
Publicado 2023

Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation

por Tillo, Miguel, Lamanna, William C., Dwyer, Chrissa A., Sandoval, Daniel R., Pessentheiner, Ariane R., Al-Azzam, Norah, Sarrazin, Stéphane, Gonzales, Jon C., Kan, Shih-Hsin, Andreyev, Alexander Y., Schultheis, Nicholas, Thacker, Bryan E., Glass, Charles A., Dickson, Patricia I., Wang, Raymond Y., Selleck, Scott B., Esko, Jeffrey D., Gordts, Philip L.S.M.
Publicado 2022

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

por Berbée, Jimmy F. P., Boon, Mariëtte R, Khedoe, P. Padmini S. J., Bartelt, Alexander, Schlein, Christian, Worthmann, Anna, Kooijman, Sander, Hoeke, Geerte, Mol, Isabel M., John, Clara, Jung, Caroline, Vazirpanah, Nadia, Brouwers, Linda P.J., Gordts, Philip L.S.M., Esko, Jeffrey D., Hiemstra, Pieter S., Havekes, Louis M., Scheja, Ludger, Heeren, Joerg, Rensen, Patrick C.N.
Publicado 2015

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

por Clausen, Thomas Mandel, Sandoval, Daniel R., Spliid, Charlotte B., Pihl, Jessica, Perrett, Hailee R., Painter, Chelsea D., Narayanan, Anoop, Majowicz, Sydney A., Kwong, Elizabeth M., McVicar, Rachael N., Thacker, Bryan E., Glass, Charles A., Yang, Zhang, Torres, Jonathan L., Golden, Gregory J., Bartels, Phillip L., Porell, Ryan N., Garretson, Aaron F., Laubach, Logan, Feldman, Jared, Yin, Xin, Pu, Yuan, Hauser, Blake M., Caradonna, Timothy M., Kellman, Benjamin P., Martino, Cameron, Gordts, Philip L.S.M., Chanda, Sumit K., Schmidt, Aaron G., Godula, Kamil, Leibel, Sandra L., Jose, Joyce, Corbett, Kevin D., Ward, Andrew B., Carlin, Aaron F., Esko, Jeffrey D.
Publicado 2020

Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction

por Akizu, Naiara, Cantagrel, Vincent, Zaki, Maha S., Al-Gazali, Lihadh, Wang, Xin, Rosti, Rasim Ozgur, Dikoglu, Esra, Gelot, Antoinette Bernabe, Rosti, Basak, Vaux, Keith K., Scott, Eric M., Silhavy, Jennifer L., Schroth, Jana, Copeland, Brett, Schaffer, Ashleigh E., Gordts, Philip, Esko, Jeffrey D., Buschman, Matthew D., Fields, Seth J., Napolitano, Gennaro, Ozgul, R. Koksal, Sagiroglu, Mahmut Samil, Azam, Matloob, Ismail, Samira, Aglan, Mona, Selim, Laila, Gamal, Iman, Hadi, Sawsan Abdel, El Badawy, Amera, Sadek, Abdelrahim A., Mojahedi, Faezeh, Kayserili, Hulya, Masri, Amira, Bastaki, Laila, Temtamy, Samia, Müller, Ulrich, Desguerre, Isabelle, Casanova, Jean-Laurent, Dursun, Ali, Gunel, Murat, Gabriel, Stacey B., de Lonlay, Pascale, Gleeson, Joseph G.
Publicado 2015