Backbone NMR assignments of the extensive human and chicken TRPV4 N-terminal intrinsically disordered regions as important players in ion channel regulation

por Goretzki, Benedikt, Tebbe, Frederike, Mitrovic, Sarah-Ana, Hellmich, Ute A.
Publicado 2022

Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk

por Heiby, Julia C., Goretzki, Benedikt, Johnson, Christopher M., Hellmich, Ute A., Neuweiler, Hannes
Publicado 2019

Extent of intrinsic disorder and NMR chemical shift assignments of the distal N-termini from human TRPV1, TRPV2 and TRPV3 ion channels

por Wiedemann, Christoph, Goretzki, Benedikt, Merz, Zoe N., Tebbe, Frederike, Schmitt, Pauline, Hellmich, Ute A.
Publicado 2022

TRPV4 mutations causing mixed neuropathy and skeletal phenotypes result in severe gain of function

por Taga, Arens, Peyton, Margo A., Goretzki, Benedikt, Gallagher, Thomas Q., Ritter, Ann, Harper, Amy, Crawford, Thomas O., Hellmich, Ute A., Sumner, Charlotte J., McCray, Brett A.
Publicado 2022

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

por McCray, Brett A., Diehl, Erika, Sullivan, Jeremy M., Aisenberg, William H., Zaccor, Nicholas W., Lau, Alexander R., Rich, Dominick J., Goretzki, Benedikt, Hellmich, Ute A., Lloyd, Thomas E., Sumner, Charlotte J.
Publicado 2021

Multiubiquitination of TRPV4 reduces channel activity independent of surface localization

por Aisenberg, William H., McCray, Brett A., Sullivan, Jeremy M., Diehl, Erika, DeVine, Lauren R., Alevy, Jonathan, Bagnell, Anna M., Carr, Patrice, Donohue, Jack K., Goretzki, Benedikt, Cole, Robert N., Hellmich, Ute A., Sumner, Charlotte J.
Publicado 2022

Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity

por Goretzki, Benedikt, Wiedemann, Christoph, McCray, Brett A., Schäfer, Stefan L., Jansen, Jasmin, Tebbe, Frederike, Mitrovic, Sarah-Ana, Nöth, Julia, Cabezudo, Ainara Claveras, Donohue, Jack K., Jeffries, Cy M., Steinchen, Wieland, Stengel, Florian, Sumner, Charlotte J., Hummer, Gerhard, Hellmich, Ute A.
Publicado 2023