Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology

por Stepper, Lisa, Filser, Florian Alois, Fischer, Simon, Schaub, Jochen, Gorr, Ingo, Voges, Raphael
Publicado 2020

Cysteine in cell culture media induces acidic IgG1 species by disrupting the disulfide bond network

por Prade, Elke, Zeck, Anne, Stiefel, Fabian, Unsoeld, Andreas, Mentrup, David, Arango Gutierrez, Erik, Gorr, Ingo H.
Publicado 2020

Structural analysis of random transgene integration in CHO manufacturing cell lines by targeted sequencing

por Stadermann, Anna, Gamer, Martin, Fieder, Jürgen, Lindner, Benjamin, Fehrmann, Steffen, Schmidt, Moritz, Schulz, Patrick, Gorr, Ingo H.
Publicado 2022

miRNA engineering of CHO cells facilitates production of difficult‐to‐express proteins and increases success in cell line development

por Fischer, Simon, Marquart, Kim F., Pieper, Lisa A., Fieder, Juergen, Gamer, Martin, Gorr, Ingo, Schulz, Patrick, Bradl, Harald
Publicado 2017

Applying intensified design of experiments to mammalian cell culture processes

por Nold, Verena, Junghans, Lisa, Bisgen, Lorenzo, Drerup, Raphael, Presser, Beate, Gorr, Ingo, Schwab, Thomas, Knapp, Bettina, Wieschalka, Stefan
Publicado 2021

Low Level Sequence Variant Analysis of Recombinant Proteins: An Optimized Approach

por Zeck, Anne, Regula, Jörg Thomas, Larraillet, Vincent, Mautz, Björn, Popp, Oliver, Göpfert, Ulrich, Wiegeshoff, Frank, Vollertsen, Ulrike E. E., Gorr, Ingo H., Koll, Hans, Papadimitriou, Apollon
Publicado 2012

Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional I...

por Klein, Christian, Waldhauer, Inja, Nicolini, Valeria G., Freimoser-Grundschober, Anne, Nayak, Tapan, Vugts, Danielle J., Dunn, Claire, Bolijn, Marije, Benz, Jörg, Stihle, Martine, Lang, Sabine, Roemmele, Michaele, Hofer, Thomas, van Puijenbroek, Erwin, Wittig, David, Moser, Samuel, Ast, Oliver, Brünker, Peter, Gorr, Ingo H., Neumann, Sebastian, de Vera Mudry, Maria Cristina, Hinton, Heather, Crameri, Flavio, Saro, Jose, Evers, Stefan, Gerdes, Christian, Bacac, Marina, van Dongen, Guus, Moessner, Ekkehard, Umaña, Pablo
Publicado 2017