Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich’s Ataxia

por Soragni, Elisabetta, Chou, C. James, Rusche, James R., Gottesfeld, Joel M.
Publicado 2015

Improved Histone Deacetylase Inhibitors as Therapeutics for the Neurodegenerative Disease Friedreich's Ataxia: A New Synthetic Route

por Xu, Chunping, Soragni, Elisabetta, Jacques, Vincent, Rusche, James R., Gottesfeld, Joel M.
Publicado 2011

Quantitative Proteomic Analysis Identifies Targets and Pathways of a 2-Aminobenzamide HDAC Inhibitor in Friedreich’s Ataxia Patient iPSC-Derived Neural Stem Cells

por Shan, Bing, Xu, Chunping, Zhang, Yaoyang, Xu, Tao, Gottesfeld, Joel M., Yates, John R.
Publicado 2014

Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates

por Tsai, Sherry M., Farkas, Michelle E., Chou, C. James, Gottesfeld, Joel M., Dervan, Peter B.
Publicado 2007

The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington’s Disease Mice

por Jia, Haiqun, Wang, Ying, Morris, Charles D., Jacques, Vincent, Gottesfeld, Joel M., Rusche, James R., Thomas, Elizabeth A.
Publicado 2016

Two New Pimelic Diphenylamide HDAC Inhibitors Induce Sustained Frataxin Upregulation in Cells from Friedreich's Ataxia Patients and in a Mouse Model

por Rai, Myriam, Soragni, Elisabetta, Chou, C. James, Barnes, Glenn, Jones, Steve, Rusche, James R., Gottesfeld, Joel M., Pandolfo, Massimo
Publicado 2010

Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy

por Soragni, Elisabetta, Petrosyan, Lina, Rinkoski, Tommy A., Wieben, Eric D., Baratz, Keith H., Fautsch, Michael P., Gottesfeld, Joel M.
Publicado 2018

HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse Model

por Rai, Myriam, Soragni, Elisabetta, Jenssen, Kai, Burnett, Ryan, Herman, David, Coppola, Giovanni, Geschwind, Daniel H., Gottesfeld, Joel M., Pandolfo, Massimo
Publicado 2008

Growth Arrest of BCR-ABL Positive Cells with a Sequence-Specific Polyamide-Chlorambucil Conjugate

por Chou, C. James, O'Hare, Thomas, Lefebvre, Sophie, Alvarez, David, Tyner, Jeffrey W., Eide, Christopher A., Druker, Brian J., Gottesfeld, Joel M.
Publicado 2008

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

por Sandi, Chiranjeevi, Pinto, Ricardo Mouro, Al-Mahdawi, Sahar, Ezzatizadeh, Vahid, Barnes, Glenn, Jones, Steve, Rusche, James R., Gottesfeld, Joel M., Pook, Mark A.
Publicado 2011

RNA Toxicity and Missplicing in the Common Eye Disease Fuchs Endothelial Corneal Dystrophy

por Du, Jintang, Aleff, Ross A., Soragni, Elisabetta, Kalari, Krishna, Nie, Jinfu, Tang, Xiaojia, Davila, Jaime, Kocher, Jean-Pierre, Patel, Sanjay V., Gottesfeld, Joel M., Baratz, Keith H., Wieben, Eric D.
Publicado 2015

Methylated and unmethylated epialleles support variegated epigenetic silencing in Friedreich ataxia

por Rodden, Layne N, Chutake, Yogesh K, Gilliam, Kaitlyn, Lam, Christina, Soragni, Elisabetta, Hauser, Lauren, Gilliam, Matthew, Wiley, Graham, Anderson, Michael P, Gottesfeld, Joel M, Lynch, David R, Bidichandani, Sanjay I
Publicado 2021

A non-synonymous single nucleotide polymorphism in SIRT6 predicts neurological severity in Friedreich ataxia

por Rodden, Layne N., Rummey, Christian, Dong, Yi Na, Lagedrost, Sarah, Regner, Sean, Brocht, Alicia, Bushara, Khalaf, Delatycki, Martin B., Gomez, Christopher M., Mathews, Katherine, Murray, Sarah, Perlman, Susan, Ravina, Bernard, Subramony, S. H., Wilmot, George, Zesiewicz, Theresa, Bolotta, Alessandra, Domissy, Alain, Jespersen, Christine, Ji, Baohu, Soragni, Elisabetta, Gottesfeld, Joel M., Lynch, David R.
Publicado 2022