Characterisation of endogenous A(2A) and A(2B) receptor-mediated cyclic AMP responses in HEK 293 cells using the GloSensor™ biosensor: Evidence for an allosteric mechanism of actio...

por Goulding, Joelle, May, Lauren T., Hill, Stephen J.
Publicado 2018

Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET

por Lay, Charles S., Bridges, Angela, Goulding, Joelle, Briddon, Stephen J., Soloviev, Zoja, Craggs, Peter D., Hill, Stephen J.
Publicado 2022

Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells

por Ogrodzinski, Lydia, Platt, Simon, Goulding, Joelle, Alexander, Cameron, Farr, Tracy D., Woolard, Jeanette, Hill, Stephen J., Kilpatrick, Laura E.
Publicado 2023

Detection of genome‐edited and endogenously expressed G protein‐coupled receptors

por Soave, Mark, Stoddart, Leigh A., White, Carl W., Kilpatrick, Laura E., Goulding, Joëlle, Briddon, Stephen J., Hill, Stephen J.
Publicado 2021

Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels

por Goulding, Joëlle, Mistry, Sarah J., Soave, Mark, Woolard, Jeanette, Briddon, Stephen J., White, Carl W., Kellam, Barrie, Hill, Stephen J.
Publicado 2021

Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor

por Dekkers, Sebastian, Caspar, Birgit, Goulding, Joëlle, Kindon, Nicholas D., Kilpatrick, Laura E., Stoddart, Leigh A., Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J., Stocks, Michael J.
Publicado 2023

Application of BRET to monitor ligand binding to GPCRs

por Stoddart, Leigh A, Johnstone, Elizabeth K M, Wheal, Amanda J, Goulding, Joëlle, Robers, Matthew B, Machleidt, Thomas, Wood, Keith V, Hill, Stephen J, Pfleger, Kevin D G
Publicado 2015

Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking

por Lucey, Maria, Ashik, Tanyel, Marzook, Amaara, Wang, Yifan, Goulding, Joëlle, Oishi, Atsuro, Broichhagen, Johannes, Hodson, David J., Minnion, James, Elani, Yuval, Jockers, Ralf, Briddon, Stephen J., Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
Publicado 2021

CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β(2)AR in isogenic hPSC-derived cardiomyocytes

por Kondrashov, Alexander, Mohd Yusof, Nurul A.N., Hasan, Alveera, Goulding, Joëlle, Kodagoda, Thusharika, Hoang, Duc M., Vo, Nguyen T.N., Melarangi, Tony, Dolatshad, Nazanin, Gorelik, Julia, Hill, Stephen J., Harding, Sian E., Denning, Chris
Publicado 2020