Precision medicine meets the DNA damage response in pancreatic cancer

por Perkhofer, Lukas, Illing, Anett, Gout, Johann, Frappart, Pierre-Olivier, Kleger, Alexander
Publicado 2018

Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks

por Perkhofer, Lukas, Engler, Melanie, Gout, Johann, Arnold, Frank, Morawe, Mareen, Breunig, Markus, Seufferlein, Thomas, Kleger, Alexander, Frappart, Pierre-Olivier
Publicado 2019

DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives

por Perkhofer, Lukas, Gout, Johann, Roger, Elodie, Kude de Almeida, Fernando, Baptista Simões, Carolina, Wiesmüller, Lisa, Seufferlein, Thomas, Kleger, Alexander
Publicado 2021

IFN-γ treatment protocol for MHC-I(lo)/PD-L1(+) pancreatic tumor cells selectively restores their TAP-mediated presentation competence and CD8 T-cell priming potential

por Stifter, Katja, Krieger, Jana, Ruths, Leonie, Gout, Johann, Mulaw, Medhanie, Lechel, Andre, Kleger, Alexander, Seufferlein, Thomas, Wagner, Martin, Schirmbeck, Reinhold
Publicado 2020

RBPJ Deficiency Sensitizes Pancreatic Acinar Cells to KRAS-Mediated Pancreatic Intraepithelial Neoplasia Initiation

por Pan, Leiling, Mulaw, Medhanie A., Gout, Johann, Guo, Min, Zarrin, Hina, Schwarz, Peggy, Baumann, Bernd, Seufferlein, Thomas, Wagner, Martin, Oswald, Franz
Publicado 2023

Maintenance Therapy for ATM-Deficient Pancreatic Cancer by Multiple DNA Damage Response Interferences after Platinum-Based Chemotherapy

por Roger, Elodie, Gout, Johann, Arnold, Frank, Beutel, Alica K., Müller, Martin, Abaei, Alireza, Barth, Thomas F. E., Rasche, Volker, Seufferlein, Thomas, Perkhofer, Lukas, Kleger, Alexander
Publicado 2020

MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo

por Walter, Karolin, Tiwary, Kanishka, Trajkovic-Arsic, Marija, Hidalgo-Sastre, Ana, Dierichs, Laura, Liffers, Sven T., Gu, Jiangning, Gout, Johann, Schulte, Lucas-Alexander, Münch, Jan, Seufferlein, Thomas, Sainz, Bruno, Siveke, Jens T., Rodriguez-Aznar, Eva, Hermann, Patrick C.
Publicado 2019

Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution

por Le Calvé, Benjamin, Griveau, Audrey, Vindrieux, David, Maréchal, Raphaël, Wiel, Clotilde, Svrcek, Magali, Gout, Johann, Azzi, Lamia, Payen, Léa, Cros, Jérôme, de la Fouchardière, Christelle, Dubus, Pierre, Guitton, Jérôme, Bartholin, Laurent, Bachet, Jean-Baptiste, Bernard, David
Publicado 2016

TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration

por Melzer, Michael Karl, Schirge, Silvia, Gout, Johann, Arnold, Frank, Srinivasan, Dharini, Burtscher, Ingo, Allgöwer, Chantal, Mulaw, Medhanie, Zengerling, Friedemann, Günes, Cagatay, Lickert, Heiko, Christoffels, Vincent M., Liebau, Stefan, Wagner, Martin, Seufferlein, Thomas, Bolenz, Christian, Moon, Anne M., Perkhofer, Lukas, Kleger, Alexander
Publicado 2023

A Prospective Feasibility Trial to Challenge Patient–Derived Pancreatic Cancer Organoids in Predicting Treatment Response

por Beutel, Alica K., Schütte, Lena, Scheible, Jeanette, Roger, Elodie, Müller, Martin, Perkhofer, Lukas, Kestler, Annika M. T. U., Kraus, Johann M., Kestler, Hans A., Barth, Thomas F. E., Lemke, Johannes, Kornmann, Marko, Ettrich, Thomas J., Gout, Johann, Seufferlein, Thomas, Kleger, Alexander
Publicado 2021

Targeting DNA Damage Repair Mechanisms in Pancreas Cancer

por Perkhofer, Lukas, Golan, Talia, Cuyle, Pieter-Jan, Matysiak-Budnik, Tamara, Van Laethem, Jean-Luc, Macarulla, Teresa, Cauchin, Estelle, Kleger, Alexander, Beutel, Alica K., Gout, Johann, Stenzinger, Albrecht, Van Cutsem, Eric, Bellmunt, Joaquim, Hammel, Pascal, O’Reilly, Eileen M., Seufferlein, Thomas
Publicado 2021

Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRAS(G12D)-driven Pancreatic Tumorigenesis

por Chuvin, Nicolas, Vincent, David F., Pommier, Roxane M., Alcaraz, Lindsay B., Gout, Johann, Caligaris, Cassandre, Yacoub, Karam, Cardot, Victoire, Roger, Elodie, Kaniewski, Bastien, Martel, Sylvie, Cintas, Celia, Goddard-Léon, Sophie, Colombe, Amélie, Valantin, Julie, Gadot, Nicolas, Servoz, Emilie, Morton, Jennifer, Goddard, Isabelle, Couvelard, Anne, Rebours, Vinciane, Guillermet, Julie, Sansom, Owen J., Treilleux, Isabelle, Valcourt, Ulrich, Sentis, Stéphanie, Dubus, Pierre, Bartholin, Laurent
Publicado 2017

Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration

por Arnold, Frank, Mahaddalkar, Pallavi U, Kraus, Johann M., Zhong, Xiaowei, Bergmann, Wendy, Srinivasan, Dharini, Gout, Johann, Roger, Elodie, Beutel, Alica K., Zizer, Eugen, Tharehalli, Umesh, Daiss, Nora, Russell, Ronan, Perkhofer, Lukas, Oellinger, Rupert, Lin, Qiong, Azoitei, Ninel, Weiss, Frank‐Ulrich, Lerch, Markus M., Liebau, Stefan, Katz, Sarah‐Fee, Lechel, André, Rad, Roland, Seufferlein, Thomas, Kestler, Hans A., Ott, Michael, Sharma, Amar Deep, Hermann, Patrick C., Kleger, Alexander
Publicado 2021

Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer

por Gout, Johann, Perkhofer, Lukas, Morawe, Mareen, Arnold, Frank, Ihle, Michaela, Biber, Stephanie, Lange, Sebastian, Roger, Elodie, Kraus, Johann M, Stifter, Katja, Hahn, Stephan A, Zamperone, Andrea, Engleitner, Thomas, Müller, Martin, Walter, Karolin, Rodriguez-Aznar, Eva, Sainz Jr, Bruno, Hermann, Patrick C, Hessmann, Elisabeth, Müller, Sebastian, Azoitei, Ninel, Lechel, André, Liebau, Stefan, Wagner, Martin, Simeone, Diane M, Kestler, Hans A, Seufferlein, Thomas, Wiesmüller, Lisa, Rad, Roland, Frappart, Pierre-Olivier, Kleger, Alexander
Publicado 2021