Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons

por Genc, Baris, Gozutok, Oge, Ozdinler, P. Hande
Publicado 2019

Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

por Gozutok, Oge, Helmold, Benjamin Ryan, Ozdinler, P. Hande
Publicado 2021

The Timing and Extent of Motor Neuron Vulnerability in ALS Correlates with Accumulation of Misfolded SOD1 Protein in the Cortex and in the Spinal Cord

por Genc, Baris, Gozutok, Oge, Kocak, Nuran, Ozdinler, P. Hande
Publicado 2020

Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS

por Dervishi, Ina, Gozutok, Oge, Murnan, Kevin, Gautam, Mukesh, Heller, Daniel, Bigio, Eileen, Ozdinler, P. Hande
Publicado 2018

Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons

por Genç, Barış, Jara, Javier H., Sanchez, Santana S., Lagrimas, Amiko K. B., Gozutok, Oge, Kocak, Nuran, Zhu, Yongling, Özdinler, P. Hande
Publicado 2022

2-Year-Old and 3-Year-Old Italian ALS Patients with Novel ALS2 Mutations: Identification of Key Metabolites in Their Serum and Plasma

por Gautam, Mukesh, Carratore, Renata Del, Helmold, Benjamin, Tessa, Alessandra, Gozutok, Oge, Chandel, Navdeep, Idrisoglu, Halil, Bongioanni, Paolo, Battini, Roberta, Ozdinler, P.Hande
Publicado 2022

Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology

por Genç, Barış, Gautam, Mukesh, Gözütok, Öge, Dervishi, Ina, Sanchez, Santana, Goshu, Gashaw M., Koçak, Nuran, Xie, Edward, Silverman, Richard B., Özdinler, P. Hande
Publicado 2021