Deficiency of Complement Component C1Q Prevents Cerebrovascular Damage and White Matter Loss in a Mouse Model of Chronic Obesity

por Graham, Leah C., Kocalis, Heidi E., Soto, Ileana, Howell, Gareth R.
Publicado 2020

Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice

por Foley, Kate E., Yang, Hongtian Stanley, Graham, Leah C., Howell, Gareth R.
Publicado 2019

Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer’s disease

por Jackson, Harriet M, Soto, Ileana, Graham, Leah C, Carter, Gregory W, Howell, Gareth R
Publicado 2013

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice

por Howell, Gareth R, Soto, Ileana, Ryan, Margaret, Graham, Leah C, Smith, Richard S, John, Simon WM
Publicado 2013

Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity

por Yang, Hongtian, Graham, Leah C., Reagan, Alaina M., Grabowska, Weronika A., Schott, William H., Howell, Gareth R.
Publicado 2019

Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease

por Graham, Leah C., Harder, Jeffrey M., Soto, Ileana, de Vries, Wilhelmine N., John, Simon W. M., Howell, Gareth R.
Publicado 2016

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction

por Soto, Ileana, Graham, Leah C., Richter, Hannah J., Simeone, Stephen N., Radell, Jake E., Grabowska, Weronika, Funkhouser, W. Keith, Howell, Megan C., Howell, Gareth R.
Publicado 2015

DBA/2J Genetic Background Exacerbates Spontaneous Lethal Seizures but Lessens Amyloid Deposition in a Mouse Model of Alzheimer’s Disease

por Jackson, Harriet M., Onos, Kristen D., Pepper, Keating W., Graham, Leah C., Akeson, Ellen C., Byers, Candice, Reinholdt, Laura G., Frankel, Wayne N., Howell, Gareth R.
Publicado 2015

TREM2 deficiency eliminates TREM2(+) inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

por Jay, Taylor R., Miller, Crystal M., Cheng, Paul J., Graham, Leah C., Bemiller, Shane, Broihier, Margaret L., Xu, Guixiang, Margevicius, Daniel, Karlo, J. Colleen, Sousa, Gregory L., Cotleur, Anne C., Butovsky, Oleg, Bekris, Lynn, Staugaitis, Susan M., Leverenz, James B., Pimplikar, Sanjay W., Landreth, Gary E., Howell, Gareth R., Ransohoff, Richard M., Lamb, Bruce T.
Publicado 2015