Sarilumab plus methotrexate suppresses circulating biomarkers of bone resorption and synovial damage in patients with rheumatoid arthritis and inadequate response to methotrexate:...

por Boyapati, Anita, Msihid, Jérôme, Fiore, Stefano, van Adelsberg, Janet, Graham, Neil M. H., Hamilton, Jennifer D.
Publicado 2016

Identification of sarilumab pharmacodynamic and predictive markers in patients with inadequate response to TNF inhibition: a biomarker substudy of the phase 3 TARGET study

por Gabay, Cem, Msihid, Jérôme, Zilberstein, Moshe, Paccard, Caroline, Lin, Yong, Graham, Neil M H, Boyapati, Anita
Publicado 2018

Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: results of a randomized, placebo-controlled phase III trial in Jap...

por Tanaka, Yoshiya, Wada, Kazuteru, Takahashi, Yoshinori, Hagino, Owen, van Hoogstraten, Hubert, Graham, Neil M. H., Kameda, Hideto
Publicado 2019

Correction to: Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: results of a randomized, placebo-controlled phase I...

por Tanaka, Yoshiya, Wada, Kazuteru, Takahashi, Yoshinori, Hagino, Owen, van Hoogstraten, Hubert, Graham, Neil M. H., Kameda, Hideto
Publicado 2019

Immunogenicity of Sarilumab Monotherapy in Patients with Rheumatoid Arthritis Who Were Inadequate Responders or Intolerant to Disease-Modifying Antirheumatic Drugs

por Wells, Alvin F., Parrino, Janie, Mangan, Erin K., Paccaly, Anne, Lin, Yong, Xu, Christine, Fan, Chunpeng, Graham, Neil M. H., van Hoogstraten, Hubert, Torri, Albert
Publicado 2019

Safety and tolerability of subcutaneous sarilumab and intravenous tocilizumab in patients with rheumatoid arthritis

por Emery, Paul, Rondon, Juan, Parrino, Janie, Lin, Yong, Pena-Rossi, Claudia, van Hoogstraten, Hubert, Graham, Neil M H, Liu, Nancy, Paccaly, Anne, Wu, Richard, Spindler, Alberto
Publicado 2019

Base and Covariate Population Pharmacokinetic Analyses of Dupilumab Using Phase 3 Data

por Kovalenko, Pavel, Davis, John D., Li, Meng, Rippley, Ronda, Ardeleanu, Marius, Shumel, Brad, Graham, Neil M.H., Pirozzi, Gianluca, Kamal, Mohamed A., DiCioccio, A. Thomas
Publicado 2020

Sarilumab and adalimumab differential effects on bone remodelling and cardiovascular risk biomarkers, and predictions of treatment outcomes

por Gabay, Cem, Burmester, Gerd R., Strand, Vibeke, Msihid, Jérôme, Zilberstein, Moshe, Kimura, Toshio, van Hoogstraten, Hubert, Boklage, Susan H., Sadeh, Jonathan, Graham, Neil M. H., Boyapati, Anita
Publicado 2020

Sarilumab plus methotrexate improves patient-reported outcomes in patients with active rheumatoid arthritis and inadequate responses to methotrexate: results of a phase III trial

por Strand, Vibeke, Kosinski, Mark, Chen, Chieh-I, Joseph, George, Rendas-Baum, Regina, Graham, Neil M. H., van Hoogstraten, Hubert, Bayliss, Martha, Fan, Chunpeng, Huizinga, Tom, Genovese, Mark C.
Publicado 2016

Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, par...

por Burmester, Gerd R, Lin, Yong, Patel, Rahul, van Adelsberg, Janet, Mangan, Erin K, Graham, Neil M H, van Hoogstraten, Hubert, Bauer, Deborah, Ignacio Vargas, Juan, Lee, Eun Bong
Publicado 2017

Sarilumab and Nonbiologic Disease‐Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis and Inadequate Response or Intolerance to Tumor Necrosis Factor Inhibit...

por Fleischmann, Roy, van Adelsberg, Janet, Lin, Yong, Castelar‐Pinheiro, Geraldo da Rocha, Brzezicki, Jan, Hrycaj, Pawel, Graham, Neil M. H., van Hoogstraten, Hubert, Bauer, Deborah, Burmester, Gerd R.
Publicado 2017

Two years of sarilumab in patients with rheumatoid arthritis and an inadequate response to MTX: safety, efficacy and radiographic outcomes

por Genovese, Mark C, van Adelsberg, Janet, Fan, Chunpeng, Graham, Neil M H, van Hoogstraten, Hubert, Parrino, Janie, Mangan, Erin K, Spindler, Alberto, Huizinga, Tom W J, van der Heijde, Désirée
Publicado 2018

Association of High Serum Interleukin‐6 Levels With Severe Progression of Rheumatoid Arthritis and Increased Treatment Response Differentiating Sarilumab From Adalimumab or Methotr...

por Boyapati, Anita, Schwartzman, Sergio, Msihid, Jérôme, Choy, Ernest, Genovese, Mark C., Burmester, Gerd R., Lam, Gordon, Kimura, Toshio, Sadeh, Jonathan, Weinreich, David M., Yancopoulos, George D., Graham, Neil M. H.
Publicado 2020

Sarilumab improves patient-reported outcomes in rheumatoid arthritis patients with inadequate response/intolerance to tumour necrosis factor inhibitors

por Strand, Vibeke, Reaney, Matthew, Chen, Chieh-I, Proudfoot, Clare W J, Guillonneau, Sophie, Bauer, Deborah, Mangan, Erin, Graham, Neil M H, van Hoogstraten, Hubert, Lin, Yong, Pacheco-Tena, César, Fleischmann, Roy
Publicado 2017

Dupilumab efficacy in adolescents with uncontrolled, moderate‐to‐severe asthma: LIBERTY ASTHMA QUEST

por Maspero, Jorge F., FitzGerald, John Mark, Pavord, Ian D., Rice, Megan S., Maroni, Jaman, Rowe, Paul J., Pirozzi, Gianluca, Amin, Nikhil, Ruddy, Marcella, Graham, Neil M. H., Teper, Ariel, Hardin, Megan
Publicado 2021

Dupilumab reduces local type 2 pro‐inflammatory biomarkers in chronic rhinosinusitis with nasal polyposis

por Jonstam, Karin, Swanson, Brian N., Mannent, Leda P., Cardell, Lars‐Olaf, Tian, Nian, Wang, Ying, Zhang, Donghui, Fan, Chunpeng, Holtappels, Gabriele, Hamilton, Jennifer D., Grabher, Annette, Graham, Neil M. H., Pirozzi, Gianluca, Bachert, Claus
Publicado 2019

Dupilumab suppresses type 2 inflammatory biomarkers across multiple atopic, allergic diseases

por Hamilton, Jennifer D., Harel, Sivan, Swanson, Brian N., Brian, William, Chen, Zhen, Rice, Megan S., Amin, Nikhil, Ardeleanu, Marius, Radin, Allen, Shumel, Brad, Ruddy, Marcella, Patel, Naimish, Pirozzi, Gianluca, Mannent, Leda, Graham, Neil M. H.
Publicado 2021

Dupilumab improves lung function in patients with uncontrolled, moderate-to-severe asthma

por Castro, Mario, Rabe, Klaus F., Corren, Jonathan, Pavord, Ian D., Katelaris, Constance H., Tohda, Yuji, Zhang, Bingzhi, Rice, Megan S., Maroni, Jaman, Rowe, Paul, Pirozzi, Gianluca, Amin, Nikhil, Ruddy, Marcella, Akinlade, Bolanle, Graham, Neil M.H., Teper, Ariel
Publicado 2020

Dupilumab Efficacy in Patients Stratified by Baseline Treatment Intensity and Lung Function

por Pavord, Ian D, Siddiqui, Salman, Papi, Alberto, Corren, Jonathan, Sher, Lawrence D, Bardin, Philip, Langton, David, Park, Hae-Sim, Rice, Megan S, Deniz, Yamo, Rowe, Paul, Staudinger, Heribert W, Patel, Naimish, Ruddy, Marcella, Graham, Neil M H, Teper, Ariel
Publicado 2020

Liberty Asthma QUEST: Phase 3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate Dupilumab Efficacy/Safety in Patients with Uncontrolled, Moderate-to-Se...

por Busse, William W., Maspero, Jorge F., Rabe, Klaus F., Papi, Alberto, Wenzel, Sally E., Ford, Linda B., Pavord, Ian D., Zhang, Bingzhi, Staudinger, Heribert, Pirozzi, Gianluca, Amin, Nikhil, Akinlade, Bolanle, Eckert, Laurent, Chao, Jingdong, Graham, Neil M. H., Teper, Ariel
Publicado 2018