Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

por Jenson, Justin M, Ryan, Jeremy A, Grant, Robert A, Letai, Anthony, Keating, Amy E
Publicado 2017

Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library

por Lite, Thuy-Lan V, Grant, Robert A, Nocedal, Isabel, Littlehale, Megan L, Guo, Monica S, Laub, Michael T
Publicado 2020

Affinity-based capture and identification of protein effectors of the growth regulator ppGpp

por Wang, Boyuan, Dai, Peng, Ding, David, Del Rosario, Amanda, Grant, Robert A., Pentelute, Bradley L., Laub, Michael T.
Publicado 2018

Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug

por Baytshtok, Vladimir, Fei, Xue, Shih, Tsai-Ting, Grant, Robert A., Santos, Justin C., Baker, Tania A., Sauer, Robert T.
Publicado 2021

A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

por Hwang, Theresa, Parker, Sara S, Hill, Samantha M, Ilunga, Meucci W, Grant, Robert A, Mouneimne, Ghassan, Keating, Amy E
Publicado 2021

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macro...

por Hymel, David, Tsuji, Kohei, Grant, Robert A., Chingle, Ramesh M., Kunciw, Dominique L., Yaffe, Michael B., Burke, Terrence R.
Publicado 2021

Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH

por Hwang, Theresa, Parker, Sara S, Hill, Samantha M, Grant, Robert A, Ilunga, Meucci W, Sivaraman, Venkatesh, Mouneimne, Ghassan, Keating, Amy E
Publicado 2022

Cardiovascular disease risk factors in chronic kidney disease: A systematic review and meta-analysis

por Major, Rupert W., Cheng, Mark R. I., Grant, Robert A., Shantikumar, Saran, Xu, Gang, Oozeerally, Issaam, Brunskill, Nigel J., Gray, Laura J.
Publicado 2018

An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp

por Ahmad, Shehryar, Wang, Boyuan, Walker, Matthew D., Tran, Hiu-Ki R., Stogios, Peter J., Savchenko, Alexei, Grant, Robert A., McArthur, Andrew G., Laub, Michael T., Whitney, John C.
Publicado 2019