Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants

por Aslanis, Vassilios, Slack, Robert J., MacKinnon, Alison C., McClinton, Catherine, Tantawi, Susan, Gravelle, Lise, Nilsson, Ulf J., Leffler, Hakon, Brooks, Ashley, Khindri, Sanjeev K., Marshall, Richard P., Pedersen, Anders, Schambye, Hans, Zetterberg, Fredrik
Publicado 2023

Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease

por Zetterberg, Fredrik R., MacKinnon, Alison, Brimert, Thomas, Gravelle, Lise, Johnsson, Richard E., Kahl-Knutson, Barbro, Leffler, Hakon, Nilsson, Ulf J., Pedersen, Anders, Peterson, Kristoffer, Roper, James A., Schambye, Hans, Slack, Robert J., Tantawi, Susan
Publicado 2022

Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis

por Hirani, Nikhil, MacKinnon, Alison C., Nicol, Lisa, Ford, Paul, Schambye, Hans, Pedersen, Anders, Nilsson, Ulf J., Leffler, Hakon, Sethi, Tariq, Tantawi, Susan, Gravelle, Lise, Slack, Robert J., Mills, Ross, Karmakar, Utsa, Humphries, Duncan, Zetterberg, Fredrik, Keeling, Lucy, Paul, Lyn, Molyneaux, Philip L., Li, Feng, Funston, Wendy, Forrest, Ian A., Simpson, A. John, Gibbons, Michael A., Maher, Toby M.
Publicado 2021

An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE)

por Gaughan, Erin E., Quinn, Tom M., Mills, Andrew, Bruce, Annya M., Antonelli, Jean, MacKinnon, Alison C., Aslanis, Vassilios, Li, Feng, O’Connor, Richard, Boz, Cecilia, Mills, Ross, Emanuel, Philip, Burgess, Matthew, Rinaldi, Giulia, Valanciute, Asta, Mills, Bethany, Scholefield, Emma, Hardisty, Gareth, Findlay, Emily Gwyer, Parker, Richard A., Norrie, John, Dear, James W., Akram, Ahsan R., Koch, Oliver, Templeton, Kate, Dockrell, David H., Walsh, Timothy S., Partridge, Stephen, Humphries, Duncan, Wang-Jairaj, Jie, Slack, Robert J., Schambye, Hans, Phung, De, Gravelle, Lise, Lindmark, Bertil, Shankar-Hari, Manu, Hirani, Nikhil, Sethi, Tariq, Dhaliwal, Kevin
Publicado 2022