A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

por Williams, Charles A. C., Gray, Nathanael S., Findlay, Greg M.
Publicado 2017

Allosteric Interactions between the Myristate- and ATP-Site of the Abl Kinase

por Iacob, Roxana E., Zhang, Jianming, Gray, Nathanael S., Engen, John R.
Publicado 2011

Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts

por Majkowska, Iwona, Shitomi, Yasuyuki, Ito, Noriko, Gray, Nathanael S., Itoh, Yoshifumi
Publicado 2017

Activation of tyrosine kinases by mutation of the gatekeeper threonine

por Azam, Mohammad, Seeliger, Markus A, Gray, Nathanael S, Kuriyan, John, Daley, George Q
Publicado 2008

BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner

por Lau, Ken S., Zhang, Tinghu, Kendall, Krystle R., Lauffenburger, Douglas, Gray, Nathanael S., Haigis, Kevin M.
Publicado 2012

Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors

por Canning, Peter, Tan, Li, Chu, Kiki, Lee, Sam W., Gray, Nathanael S., Bullock, Alex N.
Publicado 2014

Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

por Zhao, Zheng, Wu, Hong, Wang, Li, Liu, Yi, Knapp, Stefan, Liu, Qingsong, Gray, Nathanael S.
Publicado 2014

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics

por Chaikuad, Apirat, Tacconi, Eliana, Zimmer, Jutta, Liang, Yanke, Gray, Nathanael S., Tarsounas, Madalena, Knapp, Stefan
Publicado 2014

Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD(+) AML cell growth

por Weir, Mark C., Hellwig, Sabine, Tan, Li, Liu, Yao, Gray, Nathanael S., Smithgall, Thomas E.
Publicado 2017

A unifying model for mTORC1-mediated regulation of mRNA translation

por Thoreen, Carson C., Chantranupong, Lynne, Keys, Heather R., Wang, Tim, Gray, Nathanael S., Sabatini, David M.
Publicado 2012

Systematic analysis of BRAF(V)(600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis

por Fallahi-Sichani, Mohammad, Moerke, Nathan J, Niepel, Mario, Zhang, Tinghu, Gray, Nathanael S, Sorger, Peter K
Publicado 2015

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation

por Kaltheuner, Ines H., Anand, Kanchan, Moecking, Jonas, Düster, Robert, Wang, Jinhua, Gray, Nathanael S., Geyer, Matthias
Publicado 2021

Chaperones as thermodynamic sensors of drug–target interactions reveal kinase inhibitor specificities in living cells

por Taipale, Mikko, Krykbaeva, Irina, Whitesell, Luke, Santagata, Sandro, Zhang, Jianming, Liu, Qingsong, Gray, Nathanael S., Lindquist, Susan
Publicado 2013

Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

por Malik, Nazma, Vollmer, Stefan, Nanda, Sambit Kumar, Lopez-Pelaez, Marta, Prescott, Alan, Gray, Nathanael, Cohen, Philip
Publicado 2015

Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity

por Williams, Charles A.C., Fernandez-Alonso, Rosalia, Wang, Jinhua, Toth, Rachel, Gray, Nathanael S., Findlay, Greg M.
Publicado 2016

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

por Vollmer, Stefan, Strickson, Sam, Zhang, Tinghu, Gray, Nathanael, Lee, Katherine L., Rao, Vikram R., Cohen, Philip
Publicado 2017

How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion

por Chao, Luke H, Jang, Jaebong, Johnson, Adam, Nguyen, Anthony, Gray, Nathanael S, Yang, Priscilla L, Harrison, Stephen C
Publicado 2018

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function

por Saenz, Jose B., Sun, William J., Chang, Jae Won, Li, Jinmei, Bursulaya, Badry, Gray, Nathanael S., Haslam, David B.
Publicado 2009

Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer

por Terai, Hideki, Tan, Li, Beauchamp, Ellen M., Hatcher, John M., Liu, Qingsong, Meyerson, Matthew, Gray, Nathanael S., Hammerman, Peter S.
Publicado 2015

Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells

por Ho, Catherine M. K., Donovan-Banfield, I’ah Z., Tan, Li, Zhang, Tinghu, Gray, Nathanael S., Strang, Blair L.
Publicado 2016