Making the leap from structure to mechanism: are the open states of mammalian complex I identified by cryoEM resting states or catalytic intermediates?

por Chung, Injae, Grba, Daniel N., Wright, John J., Hirst, Judy
Publicado 2022

Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I

por Grba, Daniel N., Chung, Injae, Bridges, Hannah R., Agip, Ahmed-Noor A., Hirst, Judy
Publicado 2023

Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I

por Grba, Daniel N., Blaza, James N., Bridges, Hannah R., Agip, Ahmed-Noor A., Yin, Zhan, Murai, Masatoshi, Miyoshi, Hideto, Hirst, Judy
Publicado 2022

Insights into a viral motor: the structure of the HK97 packaging termination assembly

por Hawkins, Dorothy E D P, Bayfield, Oliver W, Fung, Herman K H, Grba, Daniel N, Huet, Alexis, Conway, James F, Antson, Alfred A
Publicado 2023

A conserved arginine residue is critical for stabilizing the N2 FeS cluster in mitochondrial complex I

por Hameedi, Mikhail A., Grba, Daniel N., Richardson, Katherine H., Jones, Andrew J.Y., Song, Wei, Roessler, Maxie M., Wright, John J., Hirst, Judy
Publicado 2021

Structural basis for a complex I mutation that blocks pathological ROS production

por Yin, Zhan, Burger, Nils, Kula-Alwar, Duvaraka, Aksentijević, Dunja, Bridges, Hannah R., Prag, Hiran A., Grba, Daniel N., Viscomi, Carlo, James, Andrew M., Mottahedin, Amin, Krieg, Thomas, Murphy, Michael P., Hirst, Judy
Publicado 2021