Drug Repurposing to Target Neuroinflammation and Sensory Neuron-Dependent Pain

por Sisignano, Marco, Gribbon, Philip, Geisslinger, Gerd
Publicado 2022

Mpox Knowledge Graph: a comprehensive representation embedding chemical entities and associated biology of Mpox

por Karki, Reagon, Gadiya, Yojana, Zaliani, Andrea, Gribbon, Philip
Publicado 2023

Pharmacophore-Based Machine Learning Model To Predict Ligand Selectivity for E3 Ligase Binders

por Karki, Reagon, Gadiya, Yojana, Gribbon, Philip, Zaliani, Andrea
Publicado 2023

PEMT: a patent enrichment tool for drug discovery

por Gadiya, Yojana, Zaliani, Andrea, Gribbon, Philip, Hofmann-Apitius, Martin
Publicado 2022

A high-content small molecule screen identifies novel inducers of definitive endoderm

por Korostylev, Alexander, Mahaddalkar, Pallavi U., Keminer, Oliver, Hadian, Kamyar, Schorpp, Kenji, Gribbon, Philip, Lickert, Heiko
Publicado 2017

Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent Escherichia coli ClpP Inhibitors

por Sassetti, Elisa, Durante Cruz, Cristina, Tammela, Päivi, Winterhalter, Mathias, Augustyns, Koen, Gribbon, Philip, Windshügel, Björn
Publicado 2019

The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor

por Bosma, Reggie, Witt, Gesa, Vaas, Lea A. I., Josimovic, Ivana, Gribbon, Philip, Vischer, Henry F., Gul, Sheraz, Leurs, Rob
Publicado 2017

Establishing the Secondary Metabolite Profile of the Marine Fungus: Tolypocladium geodes sp. MF458 and Subsequent Optimisation of Bioactive Secondary Metabolite Production

por Kebede, Bethlehem, Wrigley, Stephen K., Prashar, Anjali, Rahlff, Janina, Wolf, Markus, Reinshagen, Jeanette, Gribbon, Philip, Imhoff, Johannes F., Silber, Johanna, Labes, Antje, Ellinger, Bernhard
Publicado 2017

Characterization of ACE Inhibitors and AT(1)R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model

por Reus, Philipp, Schneider, Ann-Kathrin, Ulshöfer, Thomas, Henke, Marina, Bojkova, Denisa, Cinatl, Jindrich, Ciesek, Sandra, Geisslinger, Gerd, Laux, Volker, Grättinger, Mira, Gribbon, Philip, Schiffmann, Susanne
Publicado 2021

Development and implementation of a cell-based assay to discover agonists of the nuclear receptor REV-ERBα

por Hering, Yuliya, Berthier, Alexandre, Duez, Helene, Lefebvre, Philippe, Deprez, Benoit, Gribbon, Philip, Wolf, Markus, Reinshagen, Jeanette, Halley, Francoise, Hannemann, Juliane, Böger, Rainer, Staels, Bart, Gul, Sheraz
Publicado 2018

A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection

por Ellinger, Bernhard, Bojkova, Denisa, Zaliani, Andrea, Cinatl, Jindrich, Claussen, Carsten, Westhaus, Sandra, Keminer, Oliver, Reinshagen, Jeanette, Kuzikov, Maria, Wolf, Markus, Geisslinger, Gerd, Gribbon, Philip, Ciesek, Sandra
Publicado 2021

Easy access to α-ketoamides as SARS-CoV-2 and MERS M(pro) inhibitors via the PADAM oxidation route

por Pelliccia, Sveva, Cerchia, Carmen, Esposito, Francesca, Cannalire, Rolando, Corona, Angela, Costanzi, Elisa, Kuzikov, Maria, Gribbon, Philip, Zaliani, Andrea, Brindisi, Margherita, Storici, Paola, Tramontano, Enzo, Summa, Vincenzo
Publicado 2022

Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities

por Corona, Angela, Wycisk, Krzysztof, Talarico, Carmine, Manelfi, Candida, Milia, Jessica, Cannalire, Rolando, Esposito, Francesca, Gribbon, Philip, Zaliani, Andrea, Iaconis, Daniela, Beccari, Andrea R., Summa, Vincenzo, Nowotny, Marcin, Tramontano, Enzo
Publicado 2022

Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection

por de Bruin, Natasja, Schneider, Ann-Kathrin, Reus, Philipp, Talmon, Sonja, Ciesek, Sandra, Bojkova, Denisa, Cinatl, Jindrich, Lodhi, Imran, Charlesworth, Bruce, Sinclair, Simon, Pennick, Graham, Laughey, William F., Gribbon, Philip, Kannt, Aimo, Schiffmann, Susanne
Publicado 2022

Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections

por Arrazuria, Rakel, Kerscher, Bernhard, Huber, Karen E., Hoover, Jennifer L., Lundberg, Carina Vingsbo, Hansen, Jon Ulf, Sordello, Sylvie, Renard, Stephane, Aranzana-Climent, Vincent, Hughes, Diarmaid, Gribbon, Philip, Friberg, Lena E., Bekeredjian-Ding, Isabelle
Publicado 2022

Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents

por Arrazuria, Rakel, Kerscher, Bernhard, Huber, Karen E., Hoover, Jennifer L., Lundberg, Carina Vingsbo, Hansen, Jon Ulf, Sordello, Sylvie, Renard, Stephane, Aranzana-Climent, Vincent, Hughes, Diarmaid, Gribbon, Philip, Friberg, Lena E., Bekeredjian-Ding, Isabelle
Publicado 2022

DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action

por Iaconis, Daniela, Caccuri, Francesca, Manelfi, Candida, Talarico, Carmine, Bugatti, Antonella, Filippini, Federica, Zani, Alberto, Novelli, Rubina, Kuzikov, Maria, Ellinger, Bernhard, Gribbon, Philip, Riecken, Kristoffer, Esposito, Francesca, Corona, Angela, Tramontano, Enzo, Beccari, Andrea Rosario, Caruso, Arnaldo, Allegretti, Marcello
Publicado 2023

In vitro and in silico analysis of the effects of D (2) receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations

por de Witte, Wilhelmus E A, Versfelt, Joost W, Kuzikov, Maria, Rolland, Solene, Georgi, Victoria, Gribbon, Philip, Gul, Sheraz, Huntjens, Dymphy, van der Graaf, Piet Hein, Danhof, Meindert, Fernández‐Montalván, Amaury, Witt, Gesa, de Lange, Elizabeth C M
Publicado 2018

An automated and high-throughput-screening compatible pluripotent stem cell-based test platform for developmental and reproductive toxicity assessment of small molecule compounds

por Witt, Gesa, Keminer, Oliver, Leu, Jennifer, Tandon, Rashmi, Meiser, Ina, Willing, Anne, Winschel, Ingo, Abt, Jana-Christin, Brändl, Björn, Sébastien, Isabelle, Friese, Manuel A., Müller, Franz-Josef, Neubauer, Julia C., Claussen, Carsten, Zimmermann, Heiko, Gribbon, Philip, Pless, Ole
Publicado 2020

Selection of data sets for FAIRification in drug discovery and development: Which, why, and how?

por Alharbi, Ebtisam, Gadiya, Yojana, Henderson, David, Zaliani, Andrea, Delfin-Rossaro, Alejandra, Cambon-Thomsen, Anne, Kohler, Manfred, Witt, Gesa, Welter, Danielle, Juty, Nick, Jay, Caroline, Engkvist, Ola, Goble, Carole, Reilly, Dorothy S., Satagopam, Venkata, Ioannidis, Vassilios, Gu, Wei, Gribbon, Philip
Publicado 2022