AAV9-mediated central nervous system–targeted gene delivery via cisterna magna route in mice

por Lukashchuk, Vera, Lewis, Katherine E, Coldicott, Ian, Grierson, Andrew J, Azzouz, Mimoun
Publicado 2016

C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy

por Webster, Christopher P., Smith, Emma F., Grierson, Andrew J., De Vos, Kurt J.
Publicado 2016

Early Detection of Motor Dysfunction in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Using Home Cage Running Wheels

por Bennett, Ellen J., Mead, Richard J., Azzouz, Mimoun, Shaw, Pamela J., Grierson, Andrew J.
Publicado 2014

Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish

por Chapman, Anna L., Bennett, Ellen J., Ramesh, Tennore M., De Vos, Kurt J., Grierson, Andrew J.
Publicado 2013

Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS

por Ciervo, Yuri, Gatto, Noemi, Allen, Chloe, Grierson, Andrew, Ferraiuolo, Laura, Mead, Richard J., Shaw, Pamela J.
Publicado 2021

The GLP-1 receptor agonist, liraglutide, fails to slow disease progression in SOD1(G93A) and TDP-43(Q331K) transgenic mouse models of ALS

por Keerie, Amy, Brown-Wright, Heledd, Kirkland, Isaac, Grierson, Andrew, Alix, James J. P., Holscher, Christian, Mead, Richard J.
Publicado 2021

Methodological standards, quality of reporting and regulatory compliance in animal research on amyotrophic lateral sclerosis: a systematic review

por Fernandes, Joana G, Franco, Nuno H, Grierson, Andrew J, Hultgren, Jan, Furley, Andrew J W, Olsson, I Anna S
Publicado 2019

No Evidence for Cardiac Dysfunction in Kif6 Mutant Mice

por Hameed, Abdul, Bennett, Ellen, Ciani, Barbara, Hoebers, Loes P. C., Milner, Roy, Lawrie, Allan, Francis, Sheila E., Grierson, Andrew J.
Publicado 2013

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments

por Ackerley, Steven, Thornhill, Paul, Grierson, Andrew J., Brownlees, Janet, Anderton, Brian H., Leigh, P. Nigel, Shaw, Christopher E., Miller, Christopher C.J.
Publicado 2003

Glutamate Slows Axonal Transport of Neurofilaments in Transfected Neurons

por Ackerley, Steven, Grierson, Andrew J., Brownlees, Janet, Thornhill, Paul, Anderton, Brian H., Leigh, P. Nigel, Shaw, Christopher E., Miller, Christopher C.J.
Publicado 2000

Discovery of Western European R1b1a2 Y Chromosome Variants in 1000 Genomes Project Data: An Online Community Approach

por Rocca, Richard A., Magoon, Gregory, Reynolds, David F., Krahn, Thomas, Tilroe, Vincent O., Op den Velde Boots, Peter M., Grierson, Andrew J.
Publicado 2012

Correction: Discovery of Western European R1b1a2 Y Chromosome Variants in 1000 Genomes Project Data: An Online Community Approach

por Rocca, Richard A., Magoon, Gregory, Reynolds, David F., Krahn, Thomas, Tilroe, Vincent O., Op den Velde Boots, Peter M., Grierson, Andrew J.
Publicado 2012

The Effect of SOD1 Mutation on Cellular Bioenergetic Profile and Viability in Response to Oxidative Stress and Influence of Mutation-Type

por Richardson, Katie, Allen, Scott P., Mortiboys, Heather, Grierson, Andrew J., Wharton, Stephen B., Ince, Paul G., Shaw, Pamela J., Heath, Paul R.
Publicado 2013

Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish

por Hewamadduma, Channa A.A., Grierson, Andrew J., Ma, Taylur P., Pan, Luyuan, Moens, Cecilia B., Ingham, Philip W., Ramesh, Tennore, Shaw, Pamela J.
Publicado 2013

Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation

por Sardina, Francesca, Pisciottani, Alessandra, Ferrara, Manuela, Valente, Davide, Casella, Marialuisa, Crescenzi, Marco, Peschiaroli, Angelo, Casali, Carlo, Soddu, Silvia, Grierson, Andrew J, Rinaldo, Cinzia
Publicado 2020

Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia

por Łysyganicz, Paweł K., Pooranachandran, Niedharsan, Liu, Xinming, Adamson, Kathryn I., Zielonka, Katarzyna, Elworthy, Stone, van Eeden, Fredericus J., Grierson, Andrew J., Malicki, Jarema J.
Publicado 2021

Optimised and Rapid Pre-clinical Screening in the SOD1(G93A) Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS)

por Mead, Richard J., Bennett, Ellen J., Kennerley, Aneurin J., Sharp, Paul, Sunyach, Claire, Kasher, Paul, Berwick, Jason, Pettmann, Brigitte, Battaglia, Guiseppe, Azzouz, Mimoun, Grierson, Andrew, Shaw, Pamela J.
Publicado 2011

S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis()

por Mead, Richard J., Higginbottom, Adrian, Allen, Scott P., Kirby, Janine, Bennett, Ellen, Barber, Siân C., Heath, Paul R., Coluccia, Antonio, Patel, Neelam, Gardner, Iain, Brancale, Andrea, Grierson, Andrew J., Shaw, Pamela J.
Publicado 2013

An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD

por Bauer, Claudia S., Cohen, Rebecca N., Sironi, Francesca, Livesey, Matthew R., Gillingwater, Thomas H., Highley, J. Robin, Fillingham, Daniel J., Coldicott, Ian, Smith, Emma F., Gibson, Yolanda B., Webster, Christopher P., Grierson, Andrew J., Bendotti, Caterina, De Vos, Kurt J.
Publicado 2022

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

por Webster, Christopher P, Smith, Emma F, Bauer, Claudia S, Moller, Annekathrin, Hautbergue, Guillaume M, Ferraiuolo, Laura, Myszczynska, Monika A, Higginbottom, Adrian, Walsh, Matthew J, Whitworth, Alexander J, Kaspar, Brian K, Meyer, Kathrin, Shaw, Pamela J, Grierson, Andrew J, De Vos, Kurt J
Publicado 2016