Impact of oral administration of single strain Lactococcus lactis spp. cremoris on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized place...

por Saghari, Mahdi, Gal, Pim, Grievink, Hendrika W., Klaassen, Erica S., Itano, Andrea, McHale, Duncan, Moerland, Matthijs
Publicado 2022

The Effect of a 13-Valent Conjugate Pneumococcal Vaccine on Circulating Antibodies Against Oxidized LDL and Phosphorylcholine in Man, A Randomized Placebo-Controlled Clinical Trial

por Grievink, Hendrika W., Gal, Pim, Ozsvar Kozma, Maria, Klaassen, Erica S., Kuiper, Johan, Burggraaf, Jacobus, Binder, Christoph J., Moerland, Matthijs
Publicado 2020

Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release

por Tran, Thi Anh Thu, Grievink, Hendrika W., Lipinska, Katarzyna, Kluft, Cornelis, Burggraaf, Jacobus, Moerland, Matthijs, Tasev, Dimitar, Malone, Karen E.
Publicado 2019

Antimicrobial Peptide Omiganan Enhances Interferon Responses to Endosomal Toll‐Like Receptor Ligands in Human Peripheral Blood Mononuclear Cells

por Grievink, Hendrika W., Jirka, Silvana M. G., Woutman, Tess D., Schoonakker, Mascha, Rissmann, Robert, Malone, Karen E., Feiss, Gary, Moerland, Matthijs
Publicado 2020

Stimulation of the PD-1 Pathway Decreases Atherosclerotic Lesion Development in Ldlr Deficient Mice

por Grievink, Hendrika W., Smit, Virginia, Verwilligen, Robin A. F., Bernabé Kleijn, Mireia N. A., Smeets, Diede, Binder, Christoph J., Yagita, Hideo, Moerland, Matthijs, Kuiper, Johan, Bot, Ilze, Foks, Amanda C.
Publicado 2021

Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring?

por in ‘t Veld, Aliede E., Grievink, Hendrika W., Saghari, Mahdi, Stuurman, Frederik E., de Kam, Marieke L., de Vries, Aiko P. J., de Winter, Brenda C. M., Burggraaf, Jacobus, Cohen, Adam F., Moerland, Matthijs
Publicado 2019

OX40L Inhibition Suppresses KLH‐driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof‐of‐Pharmacology for KY1005

por Saghari, Mahdi, Gal, Pim, Gilbert, Sally, Yateman, Martin, Porter‐Brown, Ben, Brennan, Nuala, Quaratino, Sonia, Wilson, Rosamund, Grievink, Hendrika W., Klaassen, Erica S., Bergmann, Kirsten R., Burggraaf, Jacobus, van Doorn, Martijn B. A., Powell, John, Moerland, Matthijs, Rissmann, Robert
Publicado 2022

Clinical, Cellular, and Molecular Effects of Corticosteroids on the Response to Intradermal Lipopolysaccharide Administration in Healthy Volunteers

por Buters, Thomas P., Hameeteman, Pieter W., Jansen, Iris M.E., van Hindevoort, Floris C., ten Voorde, Wouter, Grievink, Hendrika W., Schoonakker, Mascha, de Kam, Marieke L., Gilroy, Derek W., Feiss, Gary, Rissmann, Robert, Jansen, Manon A.A., Burggraaf, Jacobus, Moerland, Matthijs
Publicado 2022

A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator

por den Heijer, Jonas M., Kruithof, Annelieke C., van Amerongen, Guido, de Kam, Marieke L., Thijssen, Eva, Grievink, Hendrika W., Moerland, Matthijs, Walker, Mike, Been, Kees, Skerlj, Renato, Justman, Craig, Dudgeon, Lindsay, Lansbury, Peter, Cullen, Valerie C., Hilt, Dana C., Groeneveld, Geert Jan
Publicado 2021

Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study

por in ‘t Veld, Aliede E., Grievink, Hendrika W., van der Plas, Johan L., Eveleens Maarse, Boukje C., van Kraaij, Sebastiaan J. W., Woutman, Tess D., Schoonakker, Mascha, Klarenbeek, Naomi B., de Kam, Marieke L., Kamerling, Ingrid M. C., Jansen, Manon A. A., Moerland, Matthijs
Publicado 2023

Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers

por Buters, Thomas P., Hameeteman, Pieter W., Jansen, Iris M. E., van Hindevoort, Floris C., ten Voorde, Wouter, Florencia, Edwin, Osse, Michelle, de Kam, Marieke L., Grievink, Hendrika W., Schoonakker, Mascha, Patel, Amit A., Yona, Simon, Gilroy, Derek W., Lubberts, Erik, Damman, Jeffrey, Feiss, Gary, Rissmann, Robert, Jansen, Manon A. A., Burggraaf, Jacobus, Moerland, Matthijs
Publicado 2021

Comprehensive evaluation of microneedle‐based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial

por Jacobse, Justin, ten Voorde, Wouter, Tandon, Anushka, Romeijn, Stefan G., Grievink, Hendrika W., van der Maaden, Koen, van Esdonk, Michiel J., Moes, Dirk Jan A.R., Loeff, Floris, Bloem, Karien, de Vries, Annick, Rispens, Theo, Wolbink, Gertjan, de Kam, Marieke, Ziagkos, Dimitrios, Moerland, Matthijs, Jiskoot, Wim, Bouwstra, Joke, Burggraaf, Jacobus, Schrier, Lenneke, Rissmann, Robert, ten Cate, Rebecca
Publicado 2021

Single-cell profiling reveals age-associated immunity in atherosclerosis

por Smit, Virginia, de Mol, Jill, Schaftenaar, Frank H, Depuydt, Marie A C, Postel, Rimke J, Smeets, Diede, Verheijen, Fenne W M, Bogers, Laurens, van Duijn, Janine, Verwilligen, Robin A F, Grievink, Hendrika W, Bernabé Kleijn, Mireia N A, van Ingen, Eva, de Jong, Maaike J M, Goncalves, Lauren, Peeters, Judith A H M, Smeets, Harm J, Wezel, Anouk, Polansky, Julia K, de Winther, Menno P J, Binder, Christoph J, Tsiantoulas, Dimitrios, Bot, Ilze, Kuiper, Johan, Foks, Amanda C
Publicado 2023