Mutual information identifies sequence positions conserved within the nuclear receptor superfamily: approach reveals functionally important regions for DNA binding specificity

por Willis, Scooter, Griffin, Patrick R.
Publicado 2011

Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity

por Corzo, Cesar, Griffin, Patrick R.
Publicado 2013

RORβ modulates a gene program that is protective against articular cartilage damage

por Chang, Mi Ra, Griffin, Patrick R.
Publicado 2022

Identification of Bexarotene as a PPARγ Antagonist with HDX

por Marciano, David P., Kuruvilla, Dana S., Pascal, Bruce D., Griffin, Patrick R.
Publicado 2015

The therapeutic potential of RORγ modulators in the treatment of human disease

por Chang, Mi Ra, Goswami, Devrishi, Mercer, Becky A, Griffin, Patrick R
Publicado 2012

One-step construction of circularized nanodiscs using SpyCatcher-SpyTag

por Zhang, Shanwen, Ren, Qian, Novick, Scott J., Strutzenberg, Timothy S., Griffin, Patrick R., Bao, Huan
Publicado 2021

Glucagon-Like Peptide-1 Receptor Ligand Interactions: Structural Cross Talk between Ligands and the Extracellular Domain

por West, Graham M., Willard, Francis S., Sloop, Kyle W., Showalter, Aaron D., Pascal, Bruce D., Griffin, Patrick R.
Publicado 2014

Osteocytes contribute via nuclear receptor PPAR-alpha to maintenance of bone and systemic energy metabolism

por Chougule, Amit, Baroi, Sudipta, Czernik, Piotr J., Crowe, Emily, Chang, Mi Ra, Griffin, Patrick R., Lecka-Czernik, Beata
Publicado 2023

Neddylation requires glycyl-tRNA synthetase to protect activated E2

por Mo, Zhongying, Zhang, Qian, Liu, Ze, Lauer, Janelle, Shi, Yi, Sun, Litao, Griffin, Patrick R., Yang, Xiang-Lei
Publicado 2016

Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2

por Chinthalapudi, Krishna, Mandati, Vinay, Zheng, Jie, Sharff, Andrew J., Bricogne, Gerard, Griffin, Patrick R., Kissil, Joseph, Izard, Tina
Publicado 2018

A Steric “Ball-and-Chain” Mechanism for pH-Mediated Regulation of Gap Junction Channels

por Khan, Ali K., Jagielnicki, Maciej, McIntire, William E., Purdy, Michael D., Dharmarajan, Venkatasubramanian, Griffin, Patrick R., Yeager, Mark
Publicado 2020

Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ

por Mosure, Sarah A., Strutzenberg, Timothy S., Shang, Jinsai, Munoz-Tello, Paola, Solt, Laura A., Griffin, Patrick R., Kojetin, Douglas J.
Publicado 2021

Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3)

por Li, Kuohan, Zheng, Jie, Wirawan, Melissa, Trinh, Nguyen Mai, Fedorova, Olga, Griffin, Patrick R, Pyle, Anna M, Luo, Dahai
Publicado 2021

PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix

por Frkic, Rebecca L., Marshall, Andrew C., Blayo, Anne-Laure, Pukala, Tara L., Kamenecka, Theodore M., Griffin, Patrick R., Bruning, John B.
Publicado 2018

Structures of the human LONP1 protease reveal regulatory steps involved in protease activation

por Shin, Mia, Watson, Edmond R., Song, Albert S., Mindrebo, Jeffrey T., Novick, Scott J., Griffin, Patrick R., Wiseman, R. Luke, Lander, Gabriel C.
Publicado 2021

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex

por Patil, Dipak N, Rangarajan, Erumbi S, Novick, Scott J, Pascal, Bruce D, Kojetin, Douglas J, Griffin, Patrick R, Izard, Tina, Martemyanov, Kirill A
Publicado 2018

Structural and Dynamic Elucidation of a Non-acid PPARγ Partial Agonist: SR1988

por Frkic, Rebecca L., Chua, Benjamin S., Shin, Youseung, Pascal, Bruce D., Novick, Scott J., Kamenecka, Theodore M., Griffin, Patrick R., Bruning, John B.
Publicado 2018

A molecular switch regulating transcriptional repression and activation of PPARγ

por Shang, Jinsai, Mosure, Sarah A., Zheng, Jie, Brust, Richard, Bass, Jared, Nichols, Ashley, Solt, Laura A., Griffin, Patrick R., Kojetin, Douglas J.
Publicado 2020

GABA(B) receptor allosteric modulators exhibit pathway‐dependent and species‐selective activity

por Sturchler, Emmanuel, Li, Xia, de Lourdes Ladino, Maria, Kaczanowska, Kasia, Cameron, Michael, Griffin, Patrick R., Finn, M. G., Markou, Athina, McDonald, Patricia
Publicado 2017

Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6

por Liu, Wallace H., Zheng, Jie, Feldman, Jessica L., Klein, Mark A., Kuznetsov, Vyacheslav I., Peterson, Craig L., Griffin, Patrick R., Denu, John M.
Publicado 2020