Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases

por Reuillon, Tristan, Alhasan, Sari F., Beale, Gary S., Bertoli, Annalisa, Brennan, Alfie, Cano, Celine, Reeves, Helen L., Newell, David R., Golding, Bernard T., Miller, Duncan C., Griffin, Roger J.
Publicado 2016

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase

por Mitcheson, Deborah F., Bottrill, Andrew R., Carr, Katherine, Coxon, Christopher R., Cano, Celine, Golding, Bernard T., Griffin, Roger J., Fry, Andrew M., Doerig, Christian, Bayliss, Richard, Tobin, Andrew B.
Publicado 2016

New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study

por Tommasino, Chiara, Gambardella, Lucrezia, Buoncervello, Maria, Griffin, Roger J., Golding, Bernard T., Alberton, Manuela, Macchia, Daniele, Spada, Massimo, Cerbelli, Bruna, d’Amati, Giulia, Malorni, Walter, Gabriele, Lucia, Giammarioli, Anna Maria
Publicado 2016

Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer

por Beale, Gary, Haagensen, Emma J, Thomas, Huw D, Wang, Lan-Zhen, Revill, Charlotte H, Payne, Sara L, Golding, Bernard T, Hardcastle, Ian R, Newell, David R, Griffin, Roger J, Cano, Celine
Publicado 2016

Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2–p53 and MDMX–p53 protein–protein interactions

por Blackburn, Tim J., Ahmed, Shafiq, Coxon, Christopher R., Liu, Junfeng, Lu, Xiaohong, Golding, Bernard T., Griffin, Roger J., Hutton, Claire, Newell, David R., Ojo, Stephen, Watson, Anna F., Zaytzev, Andrey, Zhao, Yan, Lunec, John, Hardcastle, Ian R.
Publicado 2013

TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation

por Drummond, Catherine J., Esfandiari, Arman, Liu, Junfeng, Lu, Xiaohong, Hutton, Claire, Jackson, Jennifer, Bennaceur, Karim, Xu, Qing, Makimanejavali, Aditya Rao, Bello, Fabio Del, Piergentili, Alessandro, Newell, David R., Hardcastle, Ian R., Griffin, Roger J., Lunec, John
Publicado 2016

Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer

por Coffey, Kelly, Blackburn, Timothy J., Cook, Susan, Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian R., Hewitt, Lorraine, Huberman, Kety, McNeill, Hesta V., Newell, David R., Roche, Celine, Ryan-Munden, Claudia A., Watson, Anna, Robson, Craig N.
Publicado 2012

2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase

por Matheson, Christopher J., Coxon, Christopher R., Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M., Hardcastle, Ian R., Harnor, Suzannah J., Mas-Droux, Corine, Newell, David R., Richards, Mark W., Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J., Golding, Bernard T., Cano, Céline
Publicado 2020

Structure-guided design of purine-based probes for selective Nek2 inhibition

por Coxon, Christopher R., Wong, Christopher, Bayliss, Richard, Boxall, Kathy, Carr, Katherine H., Fry, Andrew M., Hardcastle, Ian R., Matheson, Christopher J., Newell, David R., Sivaprakasam, Mangaleswaran, Thomas, Huw, Turner, David, Yeoh, Sharon, Wang, Lan Z., Griffin, Roger J., Golding, Bernard T., Cano, Céline
Publicado 2016

Identification and Characterization of an Irreversible Inhibitor of CDK2

por Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P., Staunton, David, Geitmann, Matthis, Danielson, U. Helena, Stanley, Will A., Wang, Lan Z., Reuillon, Tristan, Golding, Bernard T., Cano, Celine, Newell, David R., Noble, Martin E.M., Wedge, Stephen R., Endicott, Jane A., Griffin, Roger J.
Publicado 2015

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design

por Couty, Sylvain, Westwood, Isaac M., Kalusa, Andrew, Cano, Celine, Travers, Jon, Boxall, Kathy, Chow, Chiau Ling, Burns, Sam, Schmitt, Jessica, Pickard, Lisa, Barillari, Caterina, McAndrew, P. Craig, Clarke, Paul A., Linardopoulos, Spiros, Griffin, Roger J., Aherne, G. Wynne, Raynaud, Florence I., Workman, Paul, Jones, Keith, van Montfort, Rob L.M.
Publicado 2013

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines

por Coxon, Christopher R., Anscombe, Elizabeth, Harnor, Suzannah J., Martin, Mathew P., Carbain, Benoit, Golding, Bernard T., Hardcastle, Ian R., Harlow, Lisa K., Korolchuk, Svitlana, Matheson, Christopher J., Newell, David R., Noble, Martin E. M., Sivaprakasam, Mangaleswaran, Tudhope, Susan J., Turner, David M., Wang, Lan Z., Wedge, Stephen R., Wong, Christopher, Griffin, Roger J., Endicott, Jane A., Cano, Céline
Publicado 2016

Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy

por Willoughby, Catherine E., Jiang, Yanyan, Thomas, Huw D., Willmore, Elaine, Kyle, Suzanne, Wittner, Anita, Phillips, Nicole, Zhao, Yan, Tudhope, Susan J., Prendergast, Lisa, Junge, Gesa, Lourenco, Luiza Madia, Finlay, M. Raymond V., Turner, Paul, Munck, Joanne M., Griffin, Roger J., Rennison, Tommy, Pickles, James, Cano, Celine, Newell, David R., Reeves, Helen L., Ryan, Anderson J., Wedge, Stephen R.
Publicado 2019

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

por Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian, Harnor, Suzannah J., Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P., Martin, Nick C., Myers, Stephanie, Newell, David R., Noble, Richard A., Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A., Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine
Publicado 2022