Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2

por Sangree, Annabel K., Griffith, Audrey L., Szegletes, Zsofia M., Roy, Priyanka, DeWeirdt, Peter C., Hegde, Mudra, McGee, Abby V., Hanna, Ruth E., Doench, John G.
Publicado 2022

Optimization of Cas12a for multiplexed genome-scale transcriptional activation

por Griffith, Audrey L., Zheng, Fengyi, McGee, Abby V., Miller, Nathan W., Szegletes, Zsofia M., Reint, Ganna, Gademann, Fabian, Nwolah, Ifunanya, Hegde, Mudra, Liu, Yanjing V., Goodale, Amy, Doench, John G.
Publicado 2023

Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells

por Lenoir, W. Frank, Morgado, Micaela, DeWeirdt, Peter C., McLaughlin, Megan, Griffith, Audrey L., Sangree, Annabel K., Feeley, Marissa N., Esmaeili Anvar, Nazanin, Kim, Eiru, Bertolet, Lori L., Colic, Medina, Dede, Merve, Doench, John G., Hart, Traver
Publicado 2021

Optimization of AsCas12a for combinatorial genetic screens in human cells

por DeWeirdt, Peter C, Sanson, Kendall R, Sangree, Annabel K, Hegde, Mudra, Hanna, Ruth E, Feeley, Marissa N, Griffith, Audrey L, Teng, Teng, Borys, Samantha M, Strand, Christine, Joung, J Keith, Kleinstiver, Benjamin P, Pan, Xuewen, Huang, Alan, Doench, John G
Publicado 2020

Modular vector assembly enables rapid assessment of emerging CRISPR technologies

por McGee, Abby V., Liu, Yanjing V., Griffith, Audrey L., Szegletes, Zsofia M., Wen, Bronte, Kraus, Carolyn, Miller, Nathan W., Steger, Ryan J., Velasco, Berta Escude, Bosch, Justin A., Zirin, Jonathan D., Viswanatha, Raghuvir, Sontheimer, Erik J., Goodale, Amy, Greene, Matthew A., Green, Thomas M., Doench, John G.
Publicado 2023