Computational Evaluation of N-Based Transannular Interactions in Some Model Fused Medium-Sized Heterocyclic Systems and Implications for Drug Design

por Griffith, Renate, Bremner, John B.
Publicado 2023

Combining spatial and chemical information for clustering pharmacophores

por Zhou, Lingxiao, Griffith, Renate, Gaeta, Bruno
Publicado 2014

Differences in growth promotion, drug response and intracellular protein trafficking of FLT3 mutants

por Mashkani, Baratali, Griffith, Renate, Ashman, Leonie
Publicado 2014

Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents

por Drwal, Malgorzata N., Agama, Keli, Wakelin, Laurence P. G., Pommier, Yves, Griffith, Renate
Publicado 2011

A Novel Structural Framework for α(1A/D)-Adrenoceptor Selective Antagonists Identified Using Subtype Selective Pharmacophores

por Stoddart, Emily S., Senadheera, Sevvandi, MacDougall, Iain J. A., Griffith, Renate, Finch, Angela M.
Publicado 2011

Novel DNA Topoisomerase IIα Inhibitors from Combined Ligand- and Structure-Based Virtual Screening

por Drwal, Malgorzata N., Marinello, Jessica, Manzo, Stefano G., Wakelin, Laurence P. G., Capranico, Giovanni, Griffith, Renate
Publicado 2014

S945L-CFTR molecular dynamics, functional characterization and tezacaftor/ivacaftor efficacy in vivo and in vitro in matched pediatric patient-derived cell models

por Allan, Katelin M., Astore, Miro A., Fawcett, Laura K., Wong, Sharon L., Chen, Po-Chia, Griffith, Renate, Jaffe, Adam, Kuyucak, Serdar, Waters, Shafagh A.
Publicado 2022

Design and Synthesis of Lactams Derived from Mucochloric and Mucobromic Acids as Pseudomonas aeruginosa Quorum Sensing Inhibitors

por Almohaywi, Basmah, Taunk, Aditi, Wenholz, Daniel S., Nizalapur, Shashidhar, Biswas, Nripendra N., Ho, Kitty K. K., Rice, Scott A., Iskander, George, Black, David StC., Griffith, Renate, Kumar, Naresh
Publicado 2018

Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient

por Allan, Katelin M., Astore, Miro A., Kardia, Egi, Wong, Sharon L., Fawcett, Laura K., Bell, Jessica L., Visser, Simone, Chen, Po-Chia, Griffith, Renate, Jaffe, Adam, Sivam, Sheila, Vittorio, Orazio, Kuyucak, Serdar, Waters, Shafagh A.
Publicado 2023

Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity

por Wong, Sharon L., Awatade, Nikhil T., Astore, Miro A., Allan, Katelin M., Carnell, Michael J., Slapetova, Iveta, Chen, Po-chia, Capraro, Alexander, Fawcett, Laura K., Whan, Renee M., Griffith, Renate, Ooi, Chee Y., Kuyucak, Serdar, Jaffe, Adam, Waters, Shafagh A.
Publicado 2021

Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect

por Wong, Sharon L., Awatade, Nikhil T., Astore, Miro A., Allan, Katelin M., Carnell, Michael J., Slapetova, Iveta, Chen, Po-chia, Setiadi, Jeffry, Pandzic, Elvis, Fawcett, Laura K., Widger, John R., Whan, Renee M., Griffith, Renate, Ooi, Chee Y., Kuyucak, Serdar, Jaffe, Adam, Waters, Shafagh A.
Publicado 2022