Neuronal zinc regulation and the prion protein

por Watt, Nicole T., Griffiths, Heledd H., Hooper, Nigel M.
Publicado 2013

Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease

por Watt, Nicole T., Griffiths, Heledd H., Hooper, Nigel M.
Publicado 2014

Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1

por Rushworth, Jo V., Griffiths, Heledd H., Watt, Nicole T., Hooper, Nigel M.
Publicado 2013

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

por Jarosz-Griffiths, Heledd H., Noble, Elizabeth, Rushworth, Jo V., Hooper, Nigel M.
Publicado 2016

Dysregulated signalling pathways in innate immune cells with cystic fibrosis mutations

por Lara-Reyna, Samuel, Holbrook, Jonathan, Jarosz-Griffiths, Heledd H., Peckham, Daniel, McDermott, Michael F.
Publicado 2020

Prion protein facilitates uptake of zinc into neuronal cells

por Watt, Nicole T., Taylor, David R., Kerrigan, Talitha L., Griffiths, Heledd H., Rushworth, Jo V., Whitehouse, Isobel J., Hooper, Nigel M.
Publicado 2012

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

por Lara-Reyna, Samuel, Scambler, Thomas, Holbrook, Jonathan, Wong, Chi, Jarosz-Griffiths, Heledd H., Martinon, Fabio, Savic, Sinisa, Peckham, Daniel, McDermott, Michael F.
Publicado 2019

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

por Scambler, Thomas, Jarosz-Griffiths, Heledd H, Lara-Reyna, Samuel, Pathak, Shelly, Wong, Chi, Holbrook, Jonathan, Martinon, Fabio, Savic, Sinisa, Peckham, Daniel, McDermott, Michael F
Publicado 2019

Neurodegenerative Disease and the NLRP3 Inflammasome

por Holbrook, Jonathan A., Jarosz-Griffiths, Heledd H., Caseley, Emily, Lara-Reyna, Samuel, Poulter, James A., Williams-Gray, Caroline H., Peckham, Daniel, McDermott, Michael F.
Publicado 2021

Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1

por Dallas, Mark L., Al-Owais, Moza M., Hettiarachchi, Nishani T., Vandiver, Matthew Scott, Jarosz-Griffiths, Heledd H., Scragg, Jason L., Boyle, John P., Steele, Derek, Peers, Chris
Publicado 2021

Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

por Jarosz-Griffiths, Heledd H, Scambler, Thomas, Wong, Chi H, Lara-Reyna, Samuel, Holbrook, Jonathan, Martinon, Fabio, Savic, Sinisa, Whitaker, Paul, Etherington, Christine, Spoletini, Giulia, Clifton, Ian, Mehta, Anil, McDermott, Michael F, Peckham, Daniel
Publicado 2020

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers

por Jarosz-Griffiths, Heledd H., Corbett, Nicola J., Rowland, Helen A., Fisher, Kate, Jones, Alys C., Baron, Jennifer, Howell, Gareth J., Cowley, Sally A., Chintawar, Satyan, Cader, M. Zameel, Kellett, Katherine A. B., Hooper, Nigel M.
Publicado 2019

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil

por Sellers, Katherine J., Elliott, Christina, Jackson, Joshua, Ghosh, Anshua, Ribe, Elena, Rojo, Ana I., Jarosz-Griffiths, Heledd H., Watson, Iain A., Xia, Weiming, Semenov, Mikhail, Morin, Peter, Hooper, Nigel M., Porter, Rod, Preston, Jane, Al-Shawi, Raya, Baillie, George, Lovestone, Simon, Cuadrado, Antonio, Harte, Michael, Simons, Paul, Srivastava, Deepak P., Killick, Richard
Publicado 2018