How and Why Are Cancers Acidic? Carbonic Anhydrase IX and the Homeostatic Control of Tumour Extracellular pH

por Lee, Shen-Han, Griffiths, John R.
Publicado 2020

HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells

por Lee, Shen-Han, Golinska, Monika, Griffiths, John R.
Publicado 2021

Exploration of human brain tumour metabolism using pairwise metabolite-metabolite correlation analysis (MMCA) of HR-MAS (1)H NMR spectra

por Madhu, Basetti, Jauhiainen, Alexandra, McGuire, Sean, Griffiths, John R.
Publicado 2017

Apc(Min/+) tumours and normal mouse small intestines show linear metabolite concentration and DNA cytosine hydroxymethylation gradients from pylorus to colon

por Madhu, Basetti, Uribe-Lewis, Santiago, Bachman, Martin, Murrell, Adele, Griffiths, John R.
Publicado 2020

Response of Degarelix treatment in human prostate cancer monitored by HR-MAS (1)H NMR spectroscopy

por Madhu, Basetti, Shaw, Greg L., Warren, Anne Y., Neal, David E., Griffiths, John R.
Publicado 2016

Absolute Quantification of Endogenous Ras Isoform Abundance

por Mageean, Craig J., Griffiths, John R., Smith, Duncan L., Clague, Michael J., Prior, Ian A.
Publicado 2015

The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox

por Rodrigues, Loreta M., Uribe-Lewis, Santiago, Madhu, Basetti, Honess, Davina J., Stubbs, Marion, Griffiths, John R.
Publicado 2017

Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers

por Wright, Alan J, Fellows, Greg A, Griffiths, John R, Wilson, M, Bell, B Anthony, Howe, Franklyn A
Publicado 2010

Can localised (19)F magnetic resonance spectroscopy pharmacokinetics of 5FU in colorectal metastases predict clinical response?

por McIntyre, Dominick J. O., Howe, Franklyn A., Ladroue, Christophe, Lofts, Fiona, Stubbs, Marion, Griffiths, John R.
Publicado 2010

Metabolomic changes during cellular transformation monitored by metabolite–metabolite correlation analysis and correlated with gene expression

por Madhu, Basetti, Narita, Masako, Jauhiainen, Alexandra, Menon, Suraj, Stubbs, Marion, Tavaré, Simon, Narita, Masashi, Griffiths, John R.
Publicado 2015

Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis

por Takeda, Tetsuya, Robinson, Iain M., Savoian, Matthew M., Griffiths, John R., Whetton, Anthony D., McMahon, Harvey T., Glover, David M.
Publicado 2013

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

por Porstmann, Thomas, Santos, Claudio R., Griffiths, Beatrice, Cully, Megan, Wu, Mary, Leevers, Sally, Griffiths, John R., Chung, Yuen-Li, Schulze, Almut
Publicado 2008

A PP1/PP2A phosphatase relay controls mitotic progression

por Grallert, Agnes, Boke, Elvan, Hagting, Anja, Hodgson, Ben, Connolly, Yvonne, Griffiths, John. R., Smith, Duncan L., Pines, Jonathon, Hagan, Iain M.
Publicado 2014

Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1α Hypoxia Sensor

por Golinska, Monika A., Stubbs, Marion, Harris, Adrian L., Boros, Laszlo G., Basetti, Madhu, McIntyre, Dominick J. O., Griffiths, John R.
Publicado 2022

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

por Lee, Shen-Han, McIntyre, Dominick, Honess, Davina, Hulikova, Alzbeta, Pacheco-Torres, Jesús, Cerdán, Sebastián, Swietach, Pawel, Harris, Adrian L., Griffiths, John R.
Publicado 2018

Quantitative and textural analysis of magnetization transfer and diffusion images in the early detection of brain metastases

por Ainsworth, Nicola L., McLean, Mary A., McIntyre, Dominick J.O., Honess, Davina J., Brown, Anna M., Harden, Susan V, Griffiths, John R.
Publicado 2016

BCR-ABL Affects STAT5A and STAT5B Differentially

por Schaller-Schönitz, Michael, Barzan, David, Williamson, Andrew J. K., Griffiths, John R., Dallmann, Iris, Battmer, Karin, Ganser, Arnold, Whetton, Anthony D., Scherr, Michaela, Eder, Matthias
Publicado 2014

Muscle metabolism and activation heterogeneity by combined (31)P chemical shift and T(2) imaging, and pulmonary O(2) uptake during incremental knee-extensor exercise

por Cannon, Daniel T., Howe, Franklyn A., Whipp, Brian J., Ward, Susan A., McIntyre, Dominick J., Ladroue, Christophe, Griffiths, John R., Kemp, Graham J., Rossiter, Harry B.
Publicado 2013

Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations

por Cipriani, Valentina, Tierney, Anna, Griffiths, John R., Zuber, Verena, Sergouniotis, Panagiotis I., Yates, John R.W., Moore, Anthony T., Bishop, Paul N., Clark, Simon J., Unwin, Richard D.
Publicado 2021

Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectrosco...

por Rodrigues, Loreta M, Chung, Yuen-Li, Al Saffar, Nada M S, Sharp, Swee Y, Jackson, Laura E, Banerji, Udai, Stubbs, Marion, Leach, Martin O, Griffiths, John R, Workman, Paul
Publicado 2012