The dynamic plasticity of insulin production in β-cells

por Boland, Brandon B., Rhodes, Christopher J., Grimsby, Joseph S.
Publicado 2017

Differences in levels of phosphatidylinositols in healthy and stable Coronary Artery Disease subjects revealed by HILIC-MRM method with SERRF normalization

por Huang, Yue, Mu, Ruipeng, Wen, David, Grimsby, Joseph S., Liang, Meina, Rosenbaum, Anton I.
Publicado 2021

G(0)-G(1) Transition and the Restriction Point in Pancreatic β-Cells In Vivo

por Hija, Ayat, Salpeter, Seth, Klochendler, Agnes, Grimsby, Joseph, Brandeis, Michael, Glaser, Benjamin, Dor, Yuval
Publicado 2014

Glucokinase Activators for Diabetes Therapy: May 2010 status report

por Matschinsky, Franz M., Zelent, Bogumil, Doliba, Nicolai, Li, Changhong, Vanderkooi, Jane M., Naji, Ali, Sarabu, Ramakanth, Grimsby, Joseph
Publicado 2011

The prevalence of low muscle mass associated with obesity in the USA

por Murdock, Dana J., Wu, Ning, Grimsby, Joseph S., Calle, Roberto A., Donahue, Stephen, Glass, David J., Sleeman, Mark W., Sanchez, Robert J.
Publicado 2022

Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations

por Sayed, Samir, Langdon, David R., Odili, Stella, Chen, Pan, Buettger, Carol, Schiffman, Alisa B., Suchi, Mariko, Taub, Rebecca, Grimsby, Joseph, Matschinsky, Franz M., Stanley, Charles A.
Publicado 2009

Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation

por Tyagi, Puneet, Patel, Chandresh, Gibson, Kimberly, MacDougall, Fiona, Pechenov, Sergei Y., Will, Sarah, Revell, Jefferson, Huang, Yue, Rosenbaum, Anton I., Balic, Kemal, Maharoof, Umar, Grimsby, Joseph, Subramony, J. Anand
Publicado 2023

Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY)

por Cuesta-Muñoz, Antonio L., Tuomi, Tiinamaija, Cobo-Vuilleumier, Nadia, Koskela, Hanna, Odili, Stella, Stride, Amanda, Buettger, Carol, Otonkoski, Timo, Froguel, Philippe, Grimsby, Joseph, Garcia-Gimeno, Maria, Matschinsky, Franz M.
Publicado 2010

Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease

por Pechenov, Sergei, Revell, Jefferson, Will, Sarah, Naylor, Jacqueline, Tyagi, Puneet, Patel, Chandresh, Liang, Lihuan, Tseng, Leo, Huang, Yue, Rosenbaum, Anton I., Balic, Kemal, Konkar, Anish, Grimsby, Joseph, Subramony, J. Anand
Publicado 2021

Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy

por Valdecantos, M. Pilar, Ruiz, Laura, Pardo, Virginia, Castro-Sanchez, Luis, García-Monzón, Carmelo, Lanzón, Borja, Rupérez, Javier, Barbas, Coral, Naylor, Jaqueline, Trevaskis, James L., Grimsby, Joseph, Rondinone, Cristina M., Valverde, Ángela M.
Publicado 2018

LOX-1: A potential driver of cardiovascular risk in SLE patients

por Sagar, Divya, Gaddipati, Ranjitha, Ongstad, Emily L., Bhagroo, Nicholas, An, Ling-Ling, Wang, Jingya, Belkhodja, Mehdi, Rahman, Saifur, Manna, Zerai, Davis, Michael A., Hasni, Sarfaraz, Siegel, Richard, Sanjuan, Miguel, Grimsby, Joseph, Kolbeck, Roland, Karathanasis, Sotirios, Sims, Gary P., Gupta, Ruchi
Publicado 2020

Insights Into the Pathogenicity of Rare Missense GCK Variants From the Identification and Functional Characterization of Compound Heterozygous and Double Mutations Inherited in Cis

por Beer, Nicola L., Osbak, Kara K., van de Bunt, Martijn, Tribble, Nicholas D., Steele, Anna M., Wensley, Kirsty J., Edghill, Emma L., Colcough, Kevin, Barrett, Amy, Valentínová, Lucia, Rundle, Jana K., Raimondo, Anne, Grimsby, Joseph, Ellard, Sian, Gloyn, Anna L.
Publicado 2012

Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis

por Marchetti, Gabriela M., Burwell, Timothy J., Peterson, Norman C., Cann, Jennifer A., Hanna, Richard N., Li, Qing, Ongstad, Emily L., Boyd, Jonathan T., Kennedy, Maureen A., Zhao, Weiguang, Rickert, Keith W., Grimsby, Joseph S., Dall’Acqua, William F., Wu, Herren, Tsui, Ping, Borrok, M. Jack, Gupta, Ruchi
Publicado 2019

Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.

por Boland, Michelle L., Laker, Rhianna C., Mather, Karly, Nawrocki, Arkadiusz, Oldham, Stephanie, Boland, Brandon B., Lewis, Hilary, Conway, James, Naylor, Jacqueline, Guionaud, Silvia, Feigh, Michael, Veidal, Sanne S., Lantier, Louise, McGuinness, Owen P., Grimsby, Joseph, Rondinone, Cristina M., Jermutus, Lutz, Larsen, Martin R., Trevaskis, James L., Rhodes, Christopher J.
Publicado 2020

High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control

por Dreyfuss, Jonathan M., Yuchi, Yixing, Dong, Xuehong, Efthymiou, Vissarion, Pan, Hui, Simonson, Donald C., Vernon, Ashley, Halperin, Florencia, Aryal, Pratik, Konkar, Anish, Sebastian, Yinong, Higgs, Brandon W., Grimsby, Joseph, Rondinone, Cristina M., Kasif, Simon, Kahn, Barbara B., Foster, Kathleen, Seeley, Randy, Goldfine, Allison, Djordjilović, Vera, Patti, Mary Elizabeth
Publicado 2021

High Plasma Levels of Soluble Lectin‐like Oxidized Low‐Density Lipoprotein Receptor‐1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and...

por Stinson, Sara E., Jonsson, Anna E., Andersen, Mette K., Lund, Morten A. V., Holm, Louise Aas, Fonvig, Cilius E., Huang, Yun, Stankevič, Evelina, Juel, Helene Bæk, Ängquist, Lars, Sørensen, Thorkild I. A., Ongstad, Emily L., Gaddipati, Ranjitha, Grimsby, Joseph, Rhodes, Christopher J., Pedersen, Oluf, Christiansen, Michael, Holm, Jens‐Christian, Hansen, Torben
Publicado 2023

Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment

por Chodorge, Matthieu, Celeste, Anthony J., Grimsby, Joseph, Konkar, Anish, Davidsson, Pia, Fairman, David, Jenkinson, Lesley, Naylor, Jacqueline, White, Nicholas, Seaman, Jonathan C., Dickson, Karen, Kemp, Benjamin, Spooner, Jennifer, Rossy, Emmanuel, Hornigold, David C., Trevaskis, James L., Bond, Nicholas J., London, Timothy B., Buchanan, Andrew, Vaughan, Tristan, Rondinone, Cristina M., Osbourn, Jane K.
Publicado 2018

Peptide-YY(3-36)/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergis...

por Boland, Brandon B., Laker, Rhianna C., O'Brien, Siobhan, Sitaula, Sadichha, Sermadiras, Isabelle, Nielsen, Jens Christian, Barkholt, Pernille, Roostalu, Urmas, Hecksher-Sørensen, Jacob, Sejthen, Sara Rubek, Thorbek, Ditte Dencker, Suckow, Arthur, Burmeister, Nicole, Oldham, Stephanie, Will, Sarah, Howard, Victor G., Gill, Benji M., Newton, Philip, Naylor, Jacqueline, Hornigold, David C., Austin, Jotham, Lantier, Louise, McGuinness, Owen P., Trevaskis, James L., Grimsby, Joseph S., Rhodes, Christopher J.
Publicado 2021