Dispatching plasma membrane cholesterol and Sonic Hedgehog dispatch: two sides of the same coin?

por Ehring, Kristina, Grobe, Kay
Publicado 2021

Taking the Occam’s Razor Approach to Hedgehog Lipidation and Its Role in Development

por Manikowski, Dominique, Kastl, Philipp, Grobe, Kay
Publicado 2018

The role of glycosaminoglycan modification in Hedgehog regulated tissue morphogenesis

por Gude, Fabian, Froese, Jurij, Steffes, Georg, Grobe, Kay
Publicado 2023

Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding

por Manikowski, Dominique, Jakobs, Petra, Jboor, Hamodah, Grobe, Kay
Publicado 2019

Cerebellar Morphology and Behavioral Profiles in Mice Lacking Heparan Sulfate Ndst Gene Function

por Lewejohann, Lars, Pallerla, Srinivas R., Schreiber, Rebecca S., Gerula, Joanna, Grobe, Kay
Publicado 2020

C-Terminal Peptide Modifications Reveal Direct and Indirect Roles of Hedgehog Morphogen Cholesteroylation

por Manikowski, Dominique, Kastl, Philipp, Schürmann, Sabine, Ehring, Kristina, Steffes, Georg, Jakobs, Petra, Grobe, Kay
Publicado 2021

Surface expression of the immunotherapeutic target G(D2) in osteosarcoma depends on cell confluency

por Wiebel, Malena, Kailayangiri, Sareetha, Altvater, Bianca, Meltzer, Jutta, Grobe, Kay, Kupich, Sabine, Rossig, Claudia
Publicado 2021

Signaling Domain of Sonic Hedgehog as Cannibalistic Calcium-Regulated Zinc-Peptidase

por Rebollido-Rios, Rocio, Bandari, Shyam, Wilms, Christoph, Jakuschev, Stanislav, Vortkamp, Andrea, Grobe, Kay, Hoffmann, Daniel
Publicado 2014

Conserved cholesterol-related activities of Dispatched 1 drive Sonic hedgehog shedding from the cell membrane

por Ehring, Kristina, Manikowski, Dominique, Goretzko, Jonas, Froese, Jurij, Gude, Fabian, Jakobs, Petra, Rescher, Ursula, Kirchhefer, Uwe, Grobe, Kay
Publicado 2021

Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions

por Manikowski, Dominique, Steffes, Georg, Froese, Jurij, Exner, Sebastian, Ehring, Kristina, Gude, Fabian, Di Iorio, Daniele, Wegner, Seraphine V., Grobe, Kay
Publicado 2023

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis

por Nandadasa, Sumeda, Kraft, Caroline M., Wang, Lauren W., O’Donnell, Anna, Patel, Rushabh, Gee, Heon Yung, Grobe, Kay, Cox, Timothy C., Hildebrandt, Friedhelm, Apte, Suneel S.
Publicado 2019

Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

por Macchi, Magali, Magalon, Karine, Zimmer, Céline, Peeva, Elitsa, El Waly, Bilal, Brousse, Béatrice, Jaekel, Sarah, Grobe, Kay, Kiefer, Friedemann, Williams, Anna, Cayre, Myriam, Durbec, Pascale
Publicado 2020

Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient

por Gude, Fabian, Froese, Jurij, Manikowski, Dominique, Di Iorio, Daniele, Grad, Jean-Noël, Wegner, Seraphine, Hoffmann, Daniel, Kennedy, Melissa, Richter, Ralf P., Steffes, Georg, Grobe, Kay
Publicado 2023

Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

por Schürmann, Sabine, Steffes, Georg, Manikowski, Dominique, Kastl, Philipp, Malkus, Ursula, Bandari, Shyam, Ohlig, Stefanie, Ortmann, Corinna, Rebollido-Rios, Rocio, Otto, Mandy, Nüsse, Harald, Hoffmann, Daniel, Klämbt, Christian, Galic, Milos, Klingauf, Jürgen, Grobe, Kay
Publicado 2018