Transcriptional Silencing of the Wnt-Antagonist DKK1 by Promoter Methylation Is Associated with Enhanced Wnt Signaling in Advanced Multiple Myeloma

por Kocemba, Kinga A., Groen, Richard W. J., van Andel, Harmen, Kersten, Marie José, Mahtouk, Karène, Spaargaren, Marcel, Pals, Steven T.
Publicado 2012

Preclinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma

por Drent, Esther, Groen, Richard, Noort, Willy, van Bueren, Jeroen Lammerts, Parren, Paul, Kuball, Jürgen, Sebestyen, Zsolt, van de Donk, Niels, Martens, Anton, Lokhorst, Henk, Mutis, Tuna
Publicado 2015

Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma

por Overdijk, Marije B, Verploegen, Sandra, Bögels, Marijn, van Egmond, Marjolein, van Bueren, Jeroen J Lammerts, Mutis, Tuna, Groen, Richard WJ, Breij, Esther, Martens, Anton CM, Bleeker, Wim K, Parren, Paul WHI
Publicado 2015

Lenalidomide for the treatment of relapsed and refractory multiple myeloma

por van de Donk, Niels WCJ, Görgün, Güllü, Groen, Richard WJ, Jakubikova, Jana, Mitsiades, Constantine S, Hideshima, Teru, Laubach, Jacob, Nijhof, Inger S, Raymakers, Reinier A, Lokhorst, Henk M, Richardson, Paul G, Anderson, Kenneth C
Publicado 2012

Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model

por Varela-Moreira, Aida, van Straten, Demian, van Leur, Heleen F., Ruiter, Ruud W.J., Deshantri, Anil K., Hennink, Wim E., Fens, Marcel H.A.M., Groen, Richard W.J., Schiffelers, Raymond M.
Publicado 2020

Bone Marrow Mesenchymal Stromal Cell-mediated Resistance in Multiple Myeloma Against NK Cells can be Overcome by Introduction of CD38-CAR or TRAIL-variant

por Holthof, Lisa C., Stikvoort, Arwen, van der Horst, Hilma J., Gelderloos, Anne T., Poels, Renée, Li, Fengzhi, Groen, Richard W. J., Zweegman, Sonja, van de Donk, Niels W. C. J., O’Dwyer, Michael, Mutis, Tuna
Publicado 2021

Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A

por Sarkar, Subhashis, van Gelder, Michel, Noort, Willy, Xu, Yunping, Rouschop, Kasper M. A., Groen, Richard, Schouten, Harry C., Tilanus, Marcel G. J., Germeraad, Wilfred T. V., Martens, Anton C. M., Bos, Gerard M. J., Wieten, Lotte
Publicado 2015

SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia

por van der Werf, Inge, Wojtuszkiewicz, Anna, Yao, Huilan, Sciarrillo, Rocco, Meggendorfer, Manja, Hutter, Stephan, Walter, Wencke, Janssen, Jeroen, Kern, Wolfgang, Haferlach, Claudia, Haferlach, Torsten, Jansen, Gerrit, Kaspers, Gertjan J. L., Groen, Richard, Ossenkoppele, Gert, Cloos, Jacqueline
Publicado 2021

Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone

por Westhrin, Marita, Holien, Toril, Zahoor, Muhammad, Moen, Siv Helen, Buene, Glenn, Størdal, Berit, Hella, Hanne, Yuan, Huipin, de Bruijn, Joost D, Martens, Anton, Groen, Richard WJ, Bosch, Fatima, Smith, Ulf, Sponaas, Anne‐Marit, Sundan, Anders, Standal, Therese
Publicado 2019

CD38-specific Chimeric Antigen Receptor Expressing Natural Killer KHYG-1 Cells: A Proof of Concept for an “Off the Shelf” Therapy for Multiple Myeloma

por Stikvoort, Arwen, van der Schans, Jort, Sarkar, Subhashis, Poels, Renée, Ruiter, Ruud, Naik, Jyoti, Yuan, Huipin, de Bruijn, Joost D., van de Donk, Niels W. C. J., Zweegman, Sonja, Themeli, Maria, Groen, Richard, O’Dwyer, Michael, Mutis, Tuna
Publicado 2021

Complete Tumor Regression by Liposomal Bortezomib in a Humanized Mouse Model of Multiple Myeloma

por Deshantri, Anil K., Fens, Marcel H.A.M., Ruiter, Ruud W.J., Metselaar, Josbert M., Storm, Gert, Mandhane, Sanjay N., Graat, Gerard H.M., Lentjes, Eef G.W., Yuan, Huipin, de Bruijn, Joost D., Mutis, Tuna, Martens, Anton C.M., Groen, Richard W.J., Schiffelers, Raymond M.
Publicado 2020

Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells

por Aass, Kristin Roseth, Mjelle, Robin, Kastnes, Martin H., Tryggestad, Synne S., van den Brink, Luca M., Aass Roseth, Ingrid, Westhrin, Marita, Zahoor, Muhammad, Moen, Siv H., Vikene Nedal, Tonje M., Buene, Glenn, Misund, Kristine, Sponaas, Anne-Marit, Ma, Qianli, Sundan, Anders, Groen, Richard WJ., Slørdahl, Tobias S., Waage, Anders, Standal, Therese
Publicado 2021

Time 2EVOLVE: predicting efficacy of engineered T-cells – how far is the bench from the bedside?

por Guedan, Sonia, Luu, Maik, Ammar, Delphine, Barbao, Paula, Bonini, Chiara, Bousso, Philippe, Buchholz, Christian J, Casucci, Monica, De Angelis, Biagio, Donnadieu, Emmanuel, Espie, David, Greco, Beatrice, Groen, Richard, Huppa, Johannes B, Kantari-Mimoun, Chahrazade, Laugel, Bruno, Mantock, Mary, Markman, Janet L, Morris, Emma, Quintarelli, Concetta, Rade, Michael, Reiche, Kristin, Rodriguez-Garcia, Alba, Rodriguez-Madoz, Juan Roberto, Ruggiero, Eliana, Themeli, Maria, Hudecek, Michael, Marchiq, Ibtissam
Publicado 2022